Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal langerhans cells into potent immunostimulatory dendritic cells

Journal of Experimental Medicine

Volumn 167, Issue 2, 1988, Pages 700-705

  Heufler, Christine ^a   Koch, Franz ^a   Schuler, Gerold ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR; INTERLEUKIN 1;

ANIMAL CELL; CELL CULTURE; DENDRITIC CELL; LANGERHANS CELL; MOUSE; NONHUMAN;

ANIMAL; ANTIGEN-PRESENTING CELLS; CELL DIFFERENTIATION; CELL SURVIVAL; COLONY-STIMULATING FACTORS; EPIDERMIS; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GROWTH SUBSTANCES; INTERLEUKIN-1; LANGERHANS CELLS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; SUPPORT, NON-U.S. GOV'T;

EID: 0023867476     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.167.2.700     Document Type: Article

References (13)

1. Steinman, R. M., K. Inaba, G. Schüler, and M. Witmer. 1986. Stimulation of the immune response: contributions of dendritic cells. In Mechanisms of Host Resistance to Infectious Agents, Tumors, and Allografts. R. M. Steinman and R. J. North, editors. The Rockefeller University Press, New York. 71-97.
2. Steinman, R. M., D. S. Lustig, and Z. A. Cohn. 1974. Identification of a novel cell type in peripheral lymphoid organs of mice. III. Functional properties in vivo. J. Exp. Med. 139: 1431.
3. Schuler, G., and R. M. Steinman. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161: 526.
4. Inaba, K., G. Schuler, M. D. Witmer, J. Valinsky, B. Atassi, and R. M. Steinman. 1986. The immunologic properties of purified Langerhans cells: distinct requirements for the stimulation of unprimed and sensitized T lymphocytes. J. Exp. Med. 164: 605.
5. Tschachler, E., G. Schuler, J. Hutterer, H. Leibi, K. Wolff, and G. Stingl. 1983. Expression of Thy-1 antigen by murine epidermal cells. J. Invest. Dermatol. 81: 282.
6. Lomedico, P. T., U. Gubler, C. P. Hellmann, M. Dukovich, J. G. Giri, Y.-C. Pan, K. Collier, R. Seminow, A. O. Chua, and S. B. Mizel. 1984. Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature (Lond.). 312: 458.
7. Koide, S. L., K. Inaba, and R. M. Steinman. 1987. Interleukin-1 enhances T-dependent immune responses by amplifying the function of dendritic cells. J. Exp. Med. 165: 515.
8. Mochizuki, D. Y., J. R. Eisenman, P.J. Conlon, L. S. Park, and D. L. Urdal. 1986. Development and characterization of antiserum to murine granulocyte-macrophage colony-stimulating factor. J. Immunol. 136: 3706.
9. Luger, T. A., B. M. Stadler, B. A. Luger, B.J. Mathieson, M. Mage, J. A. Schmidt, and J. J. Oppenheim. 1982. Murine epidermal cell-derived thymocyte-activating factor resembles murine interleukin 1. J. Immunol. 128: 2147.
10. Kupper, T. S., D. W. Ballard, A. O. Chua, J. S. McGuire, P. M. Flood, M. C. Horowitz, R. Langdon, L. Lightfoot, and U. Gubler. 1986. Human keratinocytes contain mRNA indistinguishable from monocyte interleukin lα and β mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1. J. Exp. Med. 164: 2095.
11. Kupper, T. S., M. Horowitz, F. Lee, D. Coleman, and P. Flood. 1987. Molecular characterization of keratinocyte cytokines. Clin. Res. 35:697a. (Abstr.)
12. Witmer-Pack, M. D., W. Olivier.J. Valinsky, G. Schüler, and R. M. Steinman. 1987. Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J. Exp. Med. 166: 1484.
13. Witmer-Pack, M. D., J. Valinsky, W. Olivier, and R. M. Steinman. 1988. Quantitation of surface antigens on cultured murine epidermal Langerhans cells: rapid and selective increase in the level of surface MHC products. J. Invest. Dermatol. In press.