Anticonvulsant effects of some calcium entry blockers in DBA/2 mice

British Journal of Pharmacology

Volumn 93, Issue 2, 1988, Pages 247-256

  De Sarro, G B ^a   Meldrum, B S ^b   Nistico G ^a  

^a UNIVERSITY MEDITERRANEA OF REGGIO CALABRIA   (Italy)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM ANTAGONIST; DILTIAZEM; FLUNARIZINE; GALLOPAMIL; N (2 GUANIDINOETHYL) 5 ISOQUINOLINESULFONAMIDE; NICARDIPINE; NIFEDIPINE; NIMODIPINE; NITRENDIPINE; VERAPAMIL;

ANIMAL EXPERIMENT; BEHAVIOR; CALCIUM CHANNEL; CONVULSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PSYCHOLOGICAL ASPECT;

ANIMAL; ANTICONVULSANTS; CALCIUM CHANNEL BLOCKERS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MICE; MICE, INBRED DBA; SUPPORT, NON-U.S. GOV'T;

EID: 0023867358     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1988.tb11428.x     Document Type: Article

References (48)

1. Biopharmacological properties of naphthalenesulfonamide as potent calmodulin antagonist
2. Pharmacological properties of N‐(6‐aminohexyl)‐5‐chloro‐1‐naphthalenesulfonamide (W‐7), a calmodulin antagonist in arterial strips from rats and rabbits
3. Calcium entry blockers as anticonvulsant drugs in DBA/2 mice
4. Effects of some antiepileptic, neuroleptic and GABAminergic drugs on convulsions induced by D,L‐allylglycine
5. Behavioural analysis of the effects of 15 anticonvulsants in the amygdaloid kindled rat
6. The behavioural effects of the calcium agonist BAY K 8644 in the mouse: Antagonism by the calcium antagonist nifedipine
7. The agonist effect of dihydropyridines on Ca Channels
8. Evaluation of anticonvulsant drugs in DBA/2 mice with sound‐induced seizures
9. Anticonvulsant activity of intracerebroventricularly administered valproate and valproate analogues. A dose‐dependent correlation with changes in brain aspartate and GABA levels in DBA/2 mice
10. Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content
11. Anticonvulsant action of excitatory amino acid antagonists
12. Anticonvulsant and proconvulsant properties of a series of structural isomers of piperidine dicarboxylic acid
13. γ‐D‐Glutamylaminomethylsulphonic acid (GAMS) a kainate and quisqualate antagonist, prevents sound‐induced seizures in DBA/2 mice
14. Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration
15. Phenytoin: calcium and calmodulin‐dependent protein phosphorylation and neurotransmitter release
16. Benzodiazepine inhibition of the calcium‐calmodulin protein kinase system in brain membrane
17. Anticonvulsant actions of DS 103–282 pharmacological studies in rodents and the baboon, Papio papio
18. Anticonvulsant properties of flunarizine on reflex and generalised models of epilepsy
19. Anticonvulsive properties of cinnarizine and flunarizine in rats and mice
20. Verapamil concentrations in cerebrospinal fluid after oral administration
21. Comparative actions of phenytoin and other anticonvulsant drugs on potassium and veratridine‐stimulated calcium uptake in synaptosomes
22. Evidence for multiple receptor sites within the putative calcium channel
23. A specific pharmacology of calcium in myocardium, cardiac pacemakers and vascular smooth muscle
24. Calcium channels: direct identification with radio ligand binding studies
25. Mechanism of action of calcium entry blockers
26. Pharmacology of calcium entry blockers
27. Basic mechanisms and classification of calcium entry blockers
28. Phenytoin interacts with calcium channels in brain membranes
29. Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use
30. Convulsant and anticonvulsant actions in DBA/2 mice of compounds blocking the reuptake of GABA
31. ++ conductance in identified leech neurons by benzodiazepine
32. Suppression of audiogenic seizures in DBA/2 mice by two new dipeptide NMDA receptor antagonists
33. Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4‐dihydro‐2, 6‐dimethyl‐4‐(2‐nitrophenyl) −3,5‐pyridine dicarboxylate (Nisoldipine, Bay K 5552)
34. Is epilepsy a disorder of excitatory transmission?
35. Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, Papio papio
36. A comparison of the anticonvulsant potency of (±) 2‐amino‐5‐phosphonopentanoic acid and 2‐amino‐7‐phosphonoheptanoic acid
37. 45Ca: reversal by dihydropyridine calcium channel antagonists
38. Double‐bind placebo controlled trial of flunarizine as add‐on therapy in Epilepsy
39. Benzodiazepines and calcium channel function
40. A new model of experimental epilepsy: the cefazolin‐induced epilepsy
41. Anticonvulsant drug mechanisms. Phenytoin, phenobarbital and ethosuximide and calcium flux in isolated presynaptic endings
42. Micromolar‐affinity benzodiazepine receptors regulate voltage‐sensitive calcium channels in nerve terminal preparations
43. Calcium antagonists: Basic chemical and pharmacological aspects
44. Selectivity of calcium entry blockers
45. Behavioural analysis of amygdaloid kindling in beagle dogs and the effect of clonazepam, diazepam, phenobarbitone, diphenylhydantoin and flunarizine on seizure manifestation
46. Calcium entry blockers as cerebral protecting agents