메뉴 건너뛰기




Volumn 318, Issue 9, 1988, Pages 558-562

Pathogenesis and Treatment of Polycystic Ovary Syndrome

Author keywords

[No Author keywords available]

Indexed keywords

BROMOCRIPTINE; CYPROTERONE; DEXAMETHASONE; SPIRONOLACTONE;

EID: 0023864662     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198803033180906     Document Type: Review
Times cited : (159)

References (54)
  • 1
    • 0017076755 scopus 로고
    • Idiopathic hirsutism — an ovarian abnormality
    • Kirschner MA, Zucker IR, Jespersen D. Idiopathic hirsutism — an ovarian abnormality. N Engl J Med 1976; 294: 637–40.
    • (1976) N Engl J Med , vol.294 , pp. 637-640
    • Kirschner, M.A.1    Zucker, I.R.2    Jespersen, D.3
  • 2
    • 0014767566 scopus 로고
    • Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease
    • Yen SSC, Vela P, Rankin J. Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease. J Clin Endocrinol Metab 1970; 30: 435–42.
    • (1970) J Clin Endocrinol Metab , vol.30 , pp. 435-442
    • Yen, S.S.C.1    Vela, P.2    Rankin, J.3
  • 3
    • 0016316783 scopus 로고
    • Plasma testosterone in adrenal and ovarian vein blood of hirsute women
    • Oake RJ. Davies SJ, McLachlan MSF, Thomas JP. Plasma testosterone in adrenal and ovarian vein blood of hirsute women. Q J Med 1974; 43: 603–13.
    • (1974) Q J Med , vol.43 , pp. 603-613
    • Oake, R.J.1    Davies, S.J.2    McLachlan, M.S.F.3    Thomas, J.P.4
  • 4
    • 34547387827 scopus 로고
    • Congenital adrenal hyperplasia and reproductive function in females
    • In: Flamigni C, Venturoli S, Givens JR, eds. Adolescence in females. Chicago: Year Book
    • Rosenfield R. Congenital adrenal hyperplasia and reproductive function in females. In: Flamigni C, Venturoli S, Givens JR, eds. Adolescence in females. Chicago: Year Book, 1985:373–87.
    • (1985) , pp. 373-387
    • Rosenfield, R.1
  • 5
    • 0018840897 scopus 로고
    • The polycystic ovary syndrome
    • Yen SSC. The polycystic ovary syndrome. Clin Endocrinol (Oxf) 1980; 12: 177–207.
    • (1980) Clin Endocrinol (Oxf) , vol.12 , pp. 177-207
    • Yen, S.S.C.1
  • 6
    • 83455198536 scopus 로고
    • Hyperprolactinemic polycystic ovary syndrome
    • In: Mahesh VB, Greenblatt RB, eds. Hirsutism and virilism: pathogenesis, diagnosis and management. Boston: John Wright/PSG
    • Corenblum B. Hyperprolactinemic polycystic ovary syndrome. In: Mahesh VB, Greenblatt RB, eds. Hirsutism and virilism: pathogenesis, diagnosis and management. Boston: John Wright/PSG, 1983:239–46.
    • (1983) , pp. 239-246
    • Corenblum, B.1
  • 7
    • 0023336845 scopus 로고
    • The gonadotropic function of insulin
    • Poretsky L, Kalin MF. The gonadotropic function of insulin. Endocr Rev 1987; 8: 132–41.
    • (1987) Endocr Rev , vol.8 , pp. 132-141
    • Poretsky, L.1    Kalin, M.F.2
  • 8
    • 0017068476 scopus 로고
    • Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome
    • Rebar R, Judd HL, Yen SSC, Rakoff J, Vandenberg G, Naftolin F. Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest 1976; 57: 1320–9.
    • (1976) J Clin Invest , vol.57 , pp. 1320-1329
    • Rebar, R.1    Judd, H.L.2    Yen, S.S.C.3    Rakoff, J.4    Vandenberg, G.5    Naftolin, F.6
  • 9
    • 85023232040 scopus 로고
    • Correlates of gonadotropins with ovarian morphology and function throughout life
    • In: Vaitukaitis JL, ed. Clinical reproductive neuroendocrinology. New York: Elsevier Press
    • Ross GT. Correlates of gonadotropins with ovarian morphology and function throughout life. In: Vaitukaitis JL, ed. Clinical reproductive neuroendocrinology. New York: Elsevier Press, 1982:1–17.
    • (1982) , pp. 1-17
    • Ross, G.T.1
  • 10
    • 84924017867 scopus 로고
    • The polycystic ovary. 1. Clinical and histologic features
    • Goldzieher JW, Green JA. The polycystic ovary. 1. Clinical and histologic features. J Clin Endocrinol Metab 1962; 22: 325–38.
    • (1962) J Clin Endocrinol Metab , vol.22 , pp. 325-338
    • Goldzieher, J.W.1    Green, J.A.2
  • 11
    • 0019220559 scopus 로고
    • Serum sex hormone–binding globulin capacity and the percentage of free estradiol in postmenopausal women with and without endometrial carcinoma: a new biological basis for the association between obesity and endometrial carcinoma
    • Nisker JH, Hammond GL, Davidson J, et al. Serum sex hormone–binding globulin capacity and the percentage of free estradiol in postmenopausal women with and without endometrial carcinoma: a new biological basis for the association between obesity and endometrial carcinoma, Am J Obstet Gynecol 1980; 138: 637–42.
    • (1980) Am J Obstet Gynecol , vol.138 , pp. 637-642
    • Nisker, J.H.1    Hammond, G.L.2    Davidson, J.3
  • 12
    • 84995817279 scopus 로고
    • Effect of clomiphene citrate in polycystic ovary syndrome: relationship between serum gonadotropin and corpus luteum function
    • Yen SSC, Vela P, Ryan KJ. Effect of clomiphene citrate in polycystic ovary syndrome: relationship between serum gonadotropin and corpus luteum function. J Clin Endocrinol Metab 1970; 31: 7–13.
    • (1970) J Clin Endocrinol Metab , vol.31 , pp. 7-13
    • Yen, S.S.C.1    Vela, P.2    Ryan, K.J.3
  • 13
    • 10244235062 scopus 로고
    • Ovarian estradiol secretion is suppressed and the LH/FSH ratio is elevated in the common forms of amenorrhoea
    • In: Genazzani AR, Volpe A, Facchinetti F, eds. Research on gynaecological endocrinology. Carnforth, England: Parthenon
    • McKenna TJ, Cunningham SK, Loughlin T. Ovarian estradiol secretion is suppressed and the LH/FSH ratio is elevated in the common forms of amenorrhoea. In: Genazzani AR, Volpe A, Facchinetti F, eds. Research on gynaecological endocrinology. Carnforth, England: Parthenon, 1986:157–68.
    • (1986) , pp. 157-168
    • McKenna, T.J.1    Cunningham, S.K.2    Loughlin, T.3
  • 14
    • 0000840138 scopus 로고
    • Role of extraglandular estrogen in human endocrinology
    • In: Greep RO, Astwood EB, eds. Handbook of physiology. Vol. 2. Endocrinology. Washington, D.C.: American Physiology Society
    • Siiteri PK, McDonald PC. Role of extraglandular estrogen in human endocrinology. In: Greep RO, Astwood EB, eds. Handbook of physiology. Vol. 2. Endocrinology. Washington, D.C.: American Physiology Society, 1973:615–29.
    • (1973) , pp. 615-629
    • Siiteri, P.K.1    McDonald, P.C.2
  • 15
    • 0002528491 scopus 로고
    • In vitro production of androgens by virilizing adrenal adenoma and associated polycystic ovaries
    • Kase N, Kowal J, Perloff W, Soffer LJ. In vitro production of androgens by virilizing adrenal adenoma and associated polycystic ovaries. Acta Endocrinol (Copenh) 1963; 44: 15–9.
    • (1963) Acta Endocrinol (Copenh) , vol.44 , pp. 15-19
    • Kase, N.1    Kowal, J.2    Perloff, W.3    Soffer, L.J.4
  • 20
    • 0021856961 scopus 로고
    • Altered androstenedione and estrone dynamics associated with abnormal hormonal profiles in amenoirheic subjects with weight loss or obesity
    • Loughlin T, Cunningham SK, Culliton M, Smyth PPA, Meagher DJ, McKenna TJ. Altered androstenedione and estrone dynamics associated with abnormal hormonal profiles in amenoirheic subjects with weight loss or obesity. Fertil Steril 1985; 43: 720–5.
    • (1985) Fertil Steril , vol.43 , pp. 720-725
    • Loughlin, T.1    Cunningham, S.K.2    Culliton, M.3    Smyth, P.P.A.4    Meagher, D.J.5    McKenna, T.J.6
  • 21
    • 0022519137 scopus 로고
    • Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism
    • Adams J, Poison DW, Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J 1986; 293: 355–9.
    • (1986) Br Med J , vol.293 , pp. 355-359
    • Adams, J.1    Poison, D.W.2    Franks, S.3
  • 22
  • 24
    • 0016821957 scopus 로고
    • Adrenal function in hirsutism. 1. Diurnal change and response of plasma androstenedione, testosterone, 17-hydroxyprogesterone, cortisol, LH and FSH to dexamethasone and 1/2 unit of ACTH
    • Givens JR, Andersen RN, Ragland JB, Wiser WL, Umstot ES. Adrenal function in hirsutism. 1. Diurnal change and response of plasma androstenedione, testosterone, 17-hydroxyprogesterone, cortisol, LH and FSH to dexamethasone and 1/2 unit of ACTH. J Clin Endocrinol Metab 1975; 40: 988–1000.
    • (1975) J Clin Endocrinol Metab , vol.40 , pp. 988-1000
    • Givens, J.R.1    Andersen, R.N.2    Ragland, J.B.3    Wiser, W.L.4    Umstot, E.S.5
  • 25
    • 0019206840 scopus 로고
    • Adrenal function in subgroups of the PCO syndrome assessed by a long ACTH test
    • Kandeel FR, London DR. Butt WR, et al. Adrenal function in subgroups of the PCO syndrome assessed by a long ACTH test. Clin Endocrinol (Oxf) 1980; 13: 601–12.
    • (1980) Clin Endocrinol (Oxf) , vol.13 , pp. 601-612
    • Kandeel, F.R.1    London, D.R.2    Butt, W.R.3
  • 26
    • 33044498145 scopus 로고
    • Disordered puberty in treated congenital adrenal hyperplasia
    • In: Lee PA, Plotnick LP, Kowarski AA, Migeon CJ, eds. Congenital adrenal hyperplasia. Baltimore: University Park Press
    • Levine LS, Korth-Schutz S, Saenger P, Sweeney WJ III, Belling CG, New MI. Disordered puberty in treated congenital adrenal hyperplasia. In: Lee PA, Plotnick LP, Kowarski AA, Migeon CJ, eds. Congenital adrenal hyperplasia. Baltimore: University Park Press, 1977:361–78.
    • (1977) , pp. 361-378
    • Levine, L.S.1    Korth-Schutz, S.2    Saenger, P.3    Sweeney, W.J.4    Belling, C.G.5    New, M.I.6
  • 27
    • 0001698606 scopus 로고
    • Amenorrhea associated with bilateral polycystic ovaries
    • Stein IF. Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol 1935; 29: 181–91.
    • (1935) Am J Obstet Gynecol , vol.29 , pp. 181-191
    • Stein, I.F.1    Leventhal, M.L.2
  • 28
    • 0021611961 scopus 로고
    • Weight loss is associated with correction of gonadotropin and sex steroid abnormalities in the obese anovulatory female
    • Harlass FE, Plymate SR, Fariss BL, Belts RP. Weight loss is associated with correction of gonadotropin and sex steroid abnormalities in the obese anovulatory female. Fertil Steril 1984; 42: 649–52.
    • (1984) Fertil Steril , vol.42 , pp. 649-652
    • Harlass, F.E.1    Plymate, S.R.2    Fariss, B.L.3    Belts, R.P.4
  • 29
    • 0019925245 scopus 로고
    • The hyperprolactinemic polycystic ovary syndrome may not be a distinct entity
    • Corenblum B, Taylor PJ. The hyperprolactinemic polycystic ovary syndrome may not be a distinct entity. Fertil Steril 1982; 38: 549–52.
    • (1982) Fertil Steril , vol.38 , pp. 549-552
    • Corenblum, B.1    Taylor, P.J.2
  • 30
    • 0022625934 scopus 로고
    • Bromocriptine, sex steroid metabolism, and menstrual patterns in the polycystic ovary syndrome
    • Pehrson JJ, Vaitukaitis J, Longcope C. Bromocriptine, sex steroid metabolism, and menstrual patterns in the polycystic ovary syndrome. Ann Intern Med 1986; 105: 129–30.
    • (1986) Ann Intern Med , vol.105 , pp. 129-130
    • Pehrson, J.J.1    Vaitukaitis, J.2    Longcope, C.3
  • 31
    • 0016776379 scopus 로고
    • Raised serum prolactin levels associated with hirsutism and amenorrhoea
    • Seppälä M, Hirvonen E. Raised serum prolactin levels associated with hirsutism and amenorrhoea. Br Med J 1975; 4: 144–5.
    • (1975) Br Med J , vol.4 , pp. 144-145
    • Seppälä, M.1    Hirvonen, E.2
  • 32
    • 0018891299 scopus 로고
    • Galactorrhea and hyperprolactinemia during treatment of polycystic ovary syndrome
    • Wortsman J, Hirschowitz JS. Galactorrhea and hyperprolactinemia during treatment of polycystic ovary syndrome. Obstet Gynecol 1980; 55: 460–3.
    • (1980) Obstet Gynecol , vol.55 , pp. 460-463
    • Wortsman, J.1    Hirschowitz, J.S.2
  • 33
    • 0038469932 scopus 로고
    • Prolactin and cyclicity in polycystic ovary syndrome: role of estrogens and the dopaminergic system
    • del Pozo ES, Falaschi P. Prolactin and cyclicity in polycystic ovary syndrome: role of estrogens and the dopaminergic system. Prog Reprod Biol 1980; 6: 252–9.
    • (1980) Prog Reprod Biol , vol.6 , pp. 252-259
    • del Pozo, E.S.1    Falaschi, P.2
  • 34
    • 0015977539 scopus 로고
    • Augmentation of prolactin secretion by estrogen in hypogonadal women
    • Yen SSC, Ehara Y, Siler TM. Augmentation of prolactin secretion by estrogen in hypogonadal women. J Clin Invest 1974; 53: 652–5.
    • (1974) J Clin Invest , vol.53 , pp. 652-655
    • Yen, S.S.C.1    Ehara, Y.2    Siler, T.M.3
  • 35
    • 0019066328 scopus 로고
    • Control of adrenal androgen secretion
    • Parker LN, Odell DD. Control of adrenal androgen secretion. Endocr Rev 1980; 1: 392–410.
    • (1980) Endocr Rev , vol.1 , pp. 392-410
    • Parker, L.N.1    Odell, D.D.2
  • 36
    • 0018906734 scopus 로고
    • Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease
    • Burghen GA, Givens JR, Kitabchi AE. Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab 1980; 50: 113–6.
    • (1980) J Clin Endocrinol Metab , vol.50 , pp. 113-116
    • Burghen, G.A.1    Givens, J.R.2    Kitabchi, A.E.3
  • 38
    • 0022647650 scopus 로고
    • Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism
    • Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 1986; 62: 904–10.
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 904-910
    • Barbieri, R.L.1    Makris, A.2    Randall, R.W.3    Daniels, G.4    Kistner, R.W.5    Ryan, K.J.6
  • 39
    • 0001863841 scopus 로고
    • Mechanism of action of peptide hormones and catecholamines
    • In: Wilson JD, Foster DW, eds. Textbook of endocrinology. 7th ed. Philadelphia: W.B. Saunders
    • Roth J, Grunfeld C. Mechanism of action of peptide hormones and catecholamines. In: Wilson JD, Foster DW, eds. Textbook of endocrinology. 7th ed. Philadelphia: W.B. Saunders, 1985:76–122.
    • (1985) , pp. 76-122
    • Roth, J.1    Grunfeld, C.2
  • 40
    • 0022081697 scopus 로고
    • Insulinlike growth factors as intraovarian regulators of granulosa cell growth and function
    • Adashi EY, Resnick CE, D'Ercole AJ, Svoboda ME, Van Wyk JJ. Insulinlike growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev 1985; 6: 400–20.
    • (1985) Endocr Rev , vol.6 , pp. 400-420
    • Adashi, E.Y.1    Resnick, C.E.2    D'Ercole, A.J.3    Svoboda, M.E.4    Van Wyk, J.J.5
  • 42
    • 0015619233 scopus 로고
    • Serum testosterone levels in hirsute women: comparison of adrenal, ovarian and peripheral vein values
    • Stahl NL, Teeslink CR, Beauchamps G, Greenblatt RB. Serum testosterone levels in hirsute women: comparison of adrenal, ovarian and peripheral vein values. Obstet Gynecol 1973; 41: 650–4.
    • (1973) Obstet Gynecol , vol.41 , pp. 650-654
    • Stahl, N.L.1    Teeslink, C.R.2    Beauchamps, G.3    Greenblatt, R.B.4
  • 43
    • 0016769394 scopus 로고
    • Adrenal and ovarian vein androgen levels and laparoscopic findings in hirsute women
    • Northrop G, Archie JT, Patel SK, Wilbanks GD. Adrenal and ovarian vein androgen levels and laparoscopic findings in hirsute women. Am J Obstet Gynecol 1975; 122: 192–8.
    • (1975) Am J Obstet Gynecol , vol.122 , pp. 192-198
    • Northrop, G.1    Archie, J.T.2    Patel, S.K.3    Wilbanks, G.D.4
  • 44
    • 0010605194 scopus 로고
    • Role of oral contraceptives in the treatment of hyperandrogenism of hirsute women
    • In: Mahesh VB. Greenblatt RB, eds. Hirsutism and virilism: pathogenesis, diagnosis and management. Boston: John Wright/PSG
    • Givens JR. Role of oral contraceptives in the treatment of hyperandrogenism of hirsute women. In: Mahesh VB. Greenblatt RB, eds. Hirsutism and virilism: pathogenesis, diagnosis and management. Boston: John Wright/PSG, 1983:351–67.
    • (1983) , pp. 351-367
    • Givens, J.R.1
  • 45
    • 0008365218 scopus 로고
    • Hyperandrogenism and female infertility
    • In: Crosignani PG, Rubin BL, eds. Endocrinology of human infertility: new aspects. Proceedings of the Serono Clinical Colloquia on Reproduction. No. 2. London: Academic Press
    • Steinberger E, Smith KD, Rodriquez-Rigau LJ. Hyperandrogenism and female infertility. In: Crosignani PG, Rubin BL, eds. Endocrinology of human infertility: new aspects. Proceedings of the Serono Clinical Colloquia on Reproduction. No. 2. London: Academic Press, 1981:327–42.
    • (1981) , pp. 327-342
    • Steinberger, E.1    Smith, K.D.2    Rodriquez-Rigau, L.J.3
  • 46
    • 0021495875 scopus 로고
    • Female hirsutism: pathophysiological considerations and therapeutic implications
    • Biffignandi P, Massuchetti C, Molianatti GM. Female hirsutism: pathophysiological considerations and therapeutic implications. Endocr Rev 1984; 5: 489–513.
    • (1984) Endocr Rev , vol.5 , pp. 489-513
    • Biffignandi, P.1    Massuchetti, C.2    Molianatti, G.M.3
  • 47
    • 84955546902 scopus 로고
    • Adrenal secretion and ovarian dysfunction
    • In: D'Agata R, Chrousos GP, eds. Recent advances in adrenal function and regulation. New York: Raven Press
    • McKenna TJ, Cunningham S. Adrenal secretion and ovarian dysfunction. In: D'Agata R, Chrousos GP, eds. Recent advances in adrenal function and regulation. New York: Raven Press, 1987:151–63.
    • (1987) , pp. 151-163
    • McKenna, T.J.1    Cunningham, S.2
  • 49
    • 0021909171 scopus 로고
    • The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women
    • Lobo RA, Shoupe D, Serafini P. Brinton D, Horton R. The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women. Fertil Steril 1985; 43: 200–5.
    • (1985) Fertil Steril , vol.43 , pp. 200-205
    • Lobo, R.A.1    Shoupe, D.2    Serafini, P.3    Brinton, D.4    Horton, R.5
  • 50
    • 0015692106 scopus 로고
    • The use of clomiphene citrate in the treatment of anovulation
    • Kistner RW. The use of clomiphene citrate in the treatment of anovulation. Semin Drug Treat 1973; 3: 159–75.
    • (1973) Semin Drug Treat , vol.3 , pp. 159-175
    • Kistner, R.W.1
  • 51
    • 0009514355 scopus 로고
    • The pathogenesis and treatment of the polycystic ovary syndrome
    • In: Flamigni C, Venturoli S, Givens JR, eds. Adolescence in females. Chicago: Year Book
    • McKenna TJ, Loughlin T, Smyth PPA, Cunningham S. The pathogenesis and treatment of the polycystic ovary syndrome. In: Flamigni C, Venturoli S, Givens JR, eds. Adolescence in females. Chicago: Year Book, 1985:405–19.
    • (1985) , pp. 405-419
    • McKenna, T.J.1    Loughlin, T.2    Smyth, P.P.A.3    Cunningham, S.4
  • 52
    • 0022526564 scopus 로고
    • Comparative effect of cyproterone acetate and a long-acting gonadotropin-releasing hormone agonist in polycystic ovarian disease
    • Couzinet B, Le Strat N, Brailly S, Schaison G. Comparative effect of cyproterone acetate and a long-acting gonadotropin-releasing hormone agonist in polycystic ovarian disease. J Clin Endocrinol Metab 1986; 63: 1031–5.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 1031-1035
    • Couzinet, B.1    Le Strat, N.2    Brailly, S.3    Schaison, G.4
  • 53
    • 85023252888 scopus 로고
    • Urinary follicle-stimulating hormone treatment in clomipheneresistant anovulatory women with polycystic ovarian disease
    • In: Genazzani AR, Volpe A, Facchinetti F, eds. Gynaecological endocrinology: the proceedings of the First International Congress in Gynaecological Endocrinology. Carnforth, England: Parthenon
    • Nappi C. Urinary follicle-stimulating hormone treatment in clomipheneresistant anovulatory women with polycystic ovarian disease. In: Genazzani AR, Volpe A, Facchinetti F, eds. Gynaecological endocrinology: the proceedings of the First International Congress in Gynaecological Endocrinology. Carnforth, England: Parthenon, 1987:335–45.
    • (1987) , pp. 335-345
    • Nappi, C.1
  • 54
    • 0023238979 scopus 로고
    • Successful treatment of infertility due to polycystic ovary disease using a combination of luteinising hormone-releasing hormone agonist and low dosage menotrophin
    • Armitage M, Wilkin T, Dewbury K. Successful treatment of infertility due to polycystic ovary disease using a combination of luteinising hormone-releasing hormone agonist and low dosage menotrophin. Br Med J 1987; 295: 96.
    • (1987) Br Med J , vol.295 , pp. 96
    • Armitage, M.1    Wilkin, T.2    Dewbury, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.