Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia

Cancer Chemotherapy and Pharmacology

Volumn 21, Issue 2, 1988, Pages 145-149

  Schrøder, Henrik ^a   Fogh, Karsten ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MERCAPTOPURINE; METHOTREXATE;

ACUTE LYMPHOBLASTIC LEUKEMIA; CHILD; CLINICAL ARTICLE; HUMAN; ORAL DRUG ADMINISTRATION;

6-MERCAPTOPURINE; ADMINISTRATION, ORAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; ERYTHROCYTE AGING; ERYTHROCYTES; HUMAN; LEUKEMIA, LYMPHOCYTIC; METHOTREXATE; PEPTIDES; POLYGLUTAMIC ACID;

EID: 0023852189     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/BF00257362     Document Type: Article

References (29)

1. Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro
2. Polyglutamyl derivatives of methotrexate
3. A pteroylpolyglutamate binds to tetramers in deoxyhemoglobin but to dimers in oxyhemoglobin
4. The binding of folyl- and antifolylpolyglutamates to hemoglobin
5. Polyglutamation of methotrexate. Is methotrexate a prodrug?
6. Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro
7. Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate
8. Analysis of the cytotoxic determinants of methotrexate (NSC-740): a role for the “free” intracellur drug
9. The cellular pharmacology of methotrexate
10. Intracellular metabolites of methotrexate
11. Pharmacokinetics of methotrexate in erythrocytes in psoriasis
12. Changes in liver histology during methotrexate therapy of psoriasis correlated to the concentration of methotrexate and folate in erythrocytes
13. Synthesis, retention and biological activity of methotrexate polyglutamates in cultured human breast cancer cells
14. A rapid, radiochemical-ligand binding assay for methotrexate
15. Methotrexate accumulation and folate depletion as a possible mechanism of chronic toxicity to the drug
16. Methotrexate and folate content of erythrocytes in patients receiving oral vs intramuscular therapy with methotrexate
17. Analysis of methotrexate polyglutamates in vivo
18. Uptake as a determinant of methotrexate response in mouse leukemias
19. Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow
20. Separation and identification of subpicomole amounts of methotrexate in animal and human biopsy material
21. Letter to the editor
22. The reticulocytic rat: a model for analysis of methotrexate polyglutamate dynamics in situ
23. Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissue in vivo
24. Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells
25. Methotrexate polyglutamates in human sarcoma tissues and erythrocytes: Significance for efficacy of high dose therapy
26. Pharmacokinetics of erythrocyte methotrexate in children with acute lymphoblastic leukemia during maintenance treatment
27. Methotrexate in erythrocytes of patients with psoriasis
28. In vivo decline of methotrexate and methotrexate polyglutamates in age fractionated erythrocytes