Structure—Function Analysis of Murine Interferon-γ: Antiviral Properties of Novel Hybrid Interferons

Journal of Interferon Research

Volumn 8, Issue 1, 1988, Pages 5-14

  Van Heuvel, Margreet ^a   Bosveld, I Jaap ^a   Klaassen, Paul ^a   Zwarthoff, Ellen C ^a   Trapman, Jan ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA1 INTERFERON; ALPHA2 INTERFERON; ANTIVIRUS AGENT;

CELL CULTURE; INTERFERON GENE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMAL; CELL LINE; CLONING, MOLECULAR; DNA MUTATIONAL ANALYSIS; HAMSTERS; INTERFERON TYPE I; MICE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; VIRAL INTERFERENCE;

EID: 0023841787     PISSN: 01978357     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.1988.8.5     Document Type: Article

References (18)

1. WEISSMANN, C., and WEBER, H. (1986). The interferon genes. Prog. Nucleic Acid Res. Mol. Biol. 33, 251–300.
2. SHAW, G.D., BOLL, W., TAIRA, H., MANTEL, N., LENGYEL, P., and WEISSMANN, C. (1983). Structure and expression of cloned murine IFN-α genes. Nucleic Acids Res. 11, 555–573.
3. DAUGHERTY, B., MARTIN-ZANCA, D., KELDER, B., COLLIER, K., SEAMANS, T.C., HOTTA, K., and PESTKA, S. (1984). Isolation and bacterial expression of a murine alpha leukocyte interferon gene. J. Interferon Res. 4, 635–643.
4. ZWARTHOFF, E.C., MOOREN, A.T.A., and TRAPMAN, J. (1985). Organization, structure and expression of murine interferon alpha genes. Nucleic Acids Res. 13, 791–804.
5. KELLEY, K.A., and PITHA, P.M. (1985). Characterization of a mouse interferon gene locus I. Isolation of a cluster of four a interferon genes. Nucleic Acids, Res. 13, 805–823.
6. KELLEY, K.A., and PITHA, P.M. (1985). Characterization of a mouse interferon gene locus II. Differential expression of α-interferon genes. Nucleic Acids Res. 13, 825–839.
7. VAN HEUVEL, M., BOSVELD, I.J., MOOREN, A.T.A., TRAPMAN, J., and ZWARTHOFF, E.C. (1986). Properties of natural and hybrid murine alpha interferons. J. Gen. Virol. 67, 2215–2222.
8. SEIF, I., and DE MAEYER-GUIGNARD, J. (1986). Structure and expression of a new murine interferon-alpha gene: Mu IFN-α9. Gene 43, 111–121.
9. KELLEY, K.A., RAY, N.B.K., KELLUM, M., and PITHA, P.M. (1986). Synthesis of fusion and mature murine alpha interferons in Escherichia coti. Gene 45, 317–325.
10. LE ROSCOUET, D., VODJDANI, G., LEMAIGRE-DUBREUIL, Y., TOVEY, M.G., LATTA, M., and DOLY, J. (1985). Structure of a murine alpha interferon pseudogene with a repetitive R-type sequence in the 3′ flanking region. Mol. Cell. Biol. 5, 1343–1348.
11. MANIATIS, T., FRITSCH, E.F., and SAMBROOK, J. (1982). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory.
12. GLUZMAN, Y. (1981). SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23, 175–182.
13. LAEMMLI, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680–685.
14. BONNER, W.M., and LASKEY, R.A. (1974). A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. Eur. J. Biochem. 46, 83–88.
15. STREULI, M., HALL, A., BOLL, W., STEWART, W.E., NAGATA, S., and WEISSMANN, C. (1981). Target cell specificity of two species of human interferon-α produced in Escherichia coli and of hybrid molecules derived from them. Proc. Natl. Acad. Sci. USA 78, 2848–2852.
16. WECK, P.K., APPERSON, S., STEBBING, N., GRAY, P.W., LEUNG, D., SHEPARD, H.M., and GOEDDEL, D.V. (1981). Antiviral activities of hybrids of two major human leucocyte interferons. Nucleic Acids Res. 9, 6153–6166.
17. REHBERG, E., KELDER, B., HOAL, E.G., and PESTKA, S. (1982). Specific molecular activity of recombinant and hybrid leucocyte interferons. J. Biol. Chem. 257, 11497–11502.
18. MEISTER, A., UZÉ, G., MOGENSEN, K.E., GRESSER, I., TOVEY, M.G., GRÜTTER, M., and MEYER, F. (1986). Biological activities and receptor binding of two human recombinant interferons and their hybrids. J. Gen. Virol. 67, 1633r-1643.