COULD AN ENDOGENOUS BENZODIAZEPINE LIGAND CONTRIBUTE TO HEPATIC ENCEPHALOPATHY?

The Lancet

Volumn 331, Issue 8583, 1988, Pages 457-459

  Mullen, KevinD ^a,b,c   Mendelson, WallaceB ^a,b,c   Martin, JosephV ^a,b,c   Bassett, MarkL ^a,b,c   Anthony Jones, E ^a,b,c  

^a METROHEALTH MEDICAL CENTER   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR;

HEPATIC ENCEPHALOPATHY; HUMAN; PRIORITY JOURNAL; SHORT SURVEY;

BENZODIAZEPINES; FLUMAZENIL; HEPATIC ENCEPHALOPATHY; HUMAN; LIGANDS; PYRAZOLES; RECEPTORS, GABA-A; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SYNAPTIC TRANSMISSION;

EID: 0023841578     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(88)91245-7     Document Type: Article

References (38)

1. Hepatic encephalopathy and the γ-aminobutyric acid neurotransmitter system
2. Gamma-aminobutyric acid and benzodiazepine receptors in an animal model of fulminant hepatic failure
3. Searching for endogenous hgand(s) of central benzodiazepine receptors
4. Endogenous ligands of the benzodiazepine receptor
5. Hepatic encephalopathy: a syndrome modulated by an endogenous benzodiazepine ligand?
6. CSF of patients with hepatic encephalopathy (HE) contains significant benzodiazepine (BZ) binding activity Correlation with post mortem cortical BZ binding studies
7. Supersensitivity of benzodiazepine receptors in hepatic encephalopathy due to fulminant hepatic failure in the rat reversal by a benzodiazepine antagonist
8. A-benzodiazepine receptor complex in a rabbit model of fulminant hepatic failure
9. Unequivocal amelioration of hepatic encephalopathy by benzodiazepine antagonists in a rat model of fulminant hepatic failure
10. Reversal of hepatic coma by benzodiazepine antagonist (Ro 15-1788)
11. Reversal of hepatic coma by benzodiazepine antagonist (Ro 15-1788)
12. Ro 15-1788 improves coma in 4 out of 5 patients with fulminant hepatic failure; verification by long latency auditory and somatosensory evoked potentials
13. Effect of a benzodiazepine antagonist in hepatic encephalopathy
14. Successful longtime treatment of chronic hepatic encephalopathy with a benzodiazepine antagonist
15. Benzodiazepme receptor: demonstration in the central nervous system
16. Benzodiazepine receptors in rat brain
17. The benzodiazepine-GABA-chloride ionophore receptor complex. Common site of minor tranquillizer action
18. Barbiturate and benzodiazepine modulation of GABA receptor and function
19. 1 benzodiazepine receptor subclass
20. Acute, stress-induced changes in the benzodiazepine/γ-aminobutyric acid receptor complex are confined to the chloride ionophore
21. Experimental hepatic encephalopathy. Changes in the binding of γ-aminobutyric acid
22. Urinary and brain β-carboline-3-carboxylate as potent inhibitors of brain benzodiazepine receptors
23. Isolation and identification m bovine cerebral cortex of n-butyl-β-carboline-3-carboxylate, a potent benzodiazepine binding inhibitor
24. Purines as endogenous ligands for the benzodiazepine receptor
25. Nicotinamide is a brain constituent with benzodiazepine-like actions
26. Isolation, characterization and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors
27. Complete amino acid sequence of bovine and human endozepines
28. Endogenous effector of the benzodiazepine binding site. Purification and characterization
29. Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain
30. CGS 8216 receptor binding characteristics of a potent benzodiazepine antagonist
31. Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects
32. Visual evoked potentials in a rabbit model of hepatic encephalopathy I. Sequential changes and comparisons with drug-induced comas
33. Focal lesions of visual cortex. Effects on visual evoked potentials in rats
34. Bicuculline enhances a negative component and diminishes a positive component of the visual evoked potential in the cat
35. Comparative evaluation of visual evoked potentials in experimental hepatic encephalopathy and in pharmacologically-induced coma-like states in rat
36. Visual evoked potentials in encephalopathy induced by galactosamine, ammonia, dimethyldisulfide and octanoic add
37. Visual evoked potentials in a rabbit model of hepatic encephalopathy. II. Comparison of hyperammonemic encephalopathy, postictal coma, and coma induced by synergistic neurotoxins
38. Hepatic encephalopathy application of visual evoked responses to test hypotheses of its pathogenesis in rats