Concise communications fluconazole penetration into cerebrospinal fluid: Implications for treating fungal infections of the central nervous system

Journal of Infectious Diseases

Volumn 157, Issue 1, 1988, Pages 178-180

  S Arndt, Carola A ^a   Walsh, Thomas J ^a,a   McCully, Cynthia Lester ^a   Balis, Frank M ^a   Pizzo, Philip A ^a   Poplack, David G ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUCONAZOLE;

ANIMAL EXPERIMENT; APE; CASE REPORT; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; DRUG PENETRATION; FUNGUS; MYCOSIS; NONHUMAN; PRELIMINARY COMMUNICATION;

ANIMAL; CENTRAL NERVOUS SYSTEM DISEASES; CRYPTOCOCCOSIS; FLUCONAZOLE; MACACA MULATTA; MALE; TRIAZOLES;

EID: 0023839317     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/157.1.178     Document Type: Article

References (19)

1. Armstrong D, Gold JWM, Dryjanski J, Whimbey E, Polsky B, Hawkins C, Brown AE, Bernard E, Kiehn TE. Treatment of infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1985;103:738-43
2. Kovacs JA, Kovacs AA, Polis M, Wright WC, Gill VJ, Tuazon CU, Gelmann EP, Lane HC, Longfield R, Overturf Macher AM, Fauci AS, Parrillo JE, Bennett JE, Masur Cryptococcosis in the acquired immunodeficiency syndrome. Ann Intern Med 1985;103:533-8
3. Zuger A, Louie E, Holzman RS, Simberkoff MS, Rahal JJ. Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment. Ann Intern Med 1986;104:234-40
4. Bennett JE, Dismukes WE, Duma RJ, Medoff G, Sande MA, Gallis H, Leonard J, Fields BT, Bradshaw M, Haywood H, McGee ZA, Cate TR, Cobbs CG, Warner JF, Ailing DW. A comparison of amphotericin B alone and combined with flucytosine in the tratment of cryptoccal meningitis. N Engl J Med 1979;301:126-31
5. Brammer KW, Faulkner JK, Jevons S, Tarbit MH. The intravenous and oral pharmacokinetics of fluconazole in man [abstract no. 164]. In: Programs and abstracts of the 4th International Symposium on Infections in the Immunocompromised Host. Molndal, Sweden: PR offset, 1986
6. Perfect JR, Savani DV, Durack DT. Comparison of itracona zole and fluconazole in the treatment of cryptococcal meningitis and Candida pyelonephritis in rabbits. An- timicrob Agents Chemother 1986;29:579-83
7. Palou de Fernandez E, Patino MM, Graybill JR, Tarbit MH. Treatment of cryptococcal meningitis in mice with fluconazole. J Antimicrob Chemother 1986;18:261-70
8. Dupont B, Drouhet E. Cryptococcal meningitis and flucona zole. Ann Intern Med 1987;106:778
9. Wood JH, Poplack DG, Bleyer W, Ommaya AK. Primate model for long-term study of intraventricularly or intrathecally administered drugs and intracranial pressure. Science 1977;195:499-501
10. Zimm S, Collins JM, Curt GA, O’Neill D, Poplack DG. Cerebrospinal fluid pharmacokinetics of intraventricular and intravenous aziridinylbenzoquinone. Cancer Res 1984; 44:1698-1701
11. Wood JH, Poplack DG, Flor WJ, Gunby EN, Ommaya AK. Chronic ventricular cerebrospinal fluid sampling, drug injections, and pressure monitoring using subcutaneous reservoirs in monkeys. Neurosurgery 1977;1:132-5
12. Wood PR, Tarbit MH. Gas chromatographic method for the determination of fluconazole, a novel antifungal agent, in human plasma and urine. J Chromatogr 1986;383:179-86
13. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. New York: Marcel Dekker, 1982:445-9
14. Perrier D, Mayersohn M. Noncompartmental determination of the steady-state volume of distribution for any mode of administration J Pharm Sci 1982;71:372-3
15. Marriott MS, Pye GW, Richardson K, Troke PF. In Vitro activity of a novel, bis-triazole antifungal agent UK-49, 858 [abstract no. 812] In: Program and abstracts of the 25th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology, 1985
16. Daneshmend TK, Warnock DW. Clinical pharmacokinetics of systemic antifungal drugs. Clin Pharmacokinet 1983; 8:17-42
17. Deresinski SC, Lilly RB, Levine HB, Galgiani JN, Stevens DA. Treatment of fungal meningitis with miconazole. Arch Intern Med 1977;137:1180-5
18. Fisher JF, Duma RJ, Markowitz SM, Shadomy S, Espinel-Ingroff A, Chew WH. Therapeutic failures with miconazole. Antimicrob Agents Chemother 1978;13:965-8
19. Humphrey MJ, Jevons S, Tarbit MH. Pharmacokinetic evaluation of UK-49, 858, a metabolically stable triazole antifungal drug, in animals and humans. Antimicrob Agents Chemother 1985;28:648-53