Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan

Psychopharmacology

Volumn 94, Issue 4, 1988, Pages 540-544

  Livingston, S J ^a   Sewell, R D E ^a   Rooney, K F ^a   Smith, H J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Acetorphan; Enkephalinase inhibition; Naloxone; Opioid withdrawal

Indexed keywords

ACETORPHAN; MEMBRANE METALLOENDOPEPTIDASE; MORPHINE; NALOXONE;

ANIMAL EXPERIMENT; DRUG WITHDRAWAL; MALE; NONHUMAN; RAT;

AMINO ACIDS, SULFUR; ANALGESICS; ANIMAL; BODY TEMPERATURE; BODY WEIGHT; MALE; MERCAPTOPROPIONYLGLYCINE; METALLOENDOPEPTIDASES; MICE; MICE, INBRED STRAINS; MORPHINE; MORPHINE DEPENDENCE; NALOXONE; NEPRILYSIN; RATS; RATS, INBRED STRAINS; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0023839302     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/BF00212852     Document Type: Article

References (22)

1. Dynorphin-(1–13): Effects in non tolerant and morphine-dependent Rhesus monkeys
2. Physical dependence produced by chronic intracerebroventricular infusion of [D-Arg] kyotorphin or thiorphan to rats
3. Meptazinol activity on morphine-naive and morphine-dependent guinea pig ileum: correlation with in vivo studies
4. Tolerance and dependence induced by morphine-like pituitary peptides in rat
5. The effects of some antidepressants on the induction of morphine dependence and the morphine withdrawal syndrome
6. Enkephalinase inhibition suppresses naloxone-induced jumping in morphine-dependent mice
7. Hydrolysis of enkephalin by cultured human endothelial cells and by purified peptidyl dipeptidase
8. Two distinct enkephalinases: solubilization, partial purification and separation from angiotensin converting enzyme
9. Inhibition of enkephalinase activity attenuates naloxone precipitated withdrawal symptoms
10. Mode of deactivation of enkephalins by rat and human plasma and rat brain homogenates
11. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse
12. Minireview: An animal behaviour model for studying central serotonergic synapses
13. Stereospecific and nonstereospecific effects of (+) and (-)morphine: Evidence for a new class of receptors?
14. The effects of d-phenylalanine and its derivatives on enkephalin degradation in vitro: relation to analgesia and attenuation of the morphine withdrawal syndrome
15. Sites of action of morphine involved in the development of physical dependence in rats
16. Pharmacological properties of acetorphan, a parenterally active “enkephalinase” inhibitor
17. High-affinity enkephalin-degrading peptidase in brain is increased after morphine
18. Peptidase inhibitors reduce opiate narcotic withdrawal signs, including seizure activity in the rat
19. Evidence that drug increasing 5-hydroxytriptamine transmission blocks jumping but not wet dog shakes in morphine abstinent rats: a comparison with clonidine
20. Antinociceptive activity of narcotic agonist and partial agonist analgesics and other agents in the tail immersion test in mice and rats
21. Suppression of withdrawal symptoms by dynorphin in heroin addicts