Radioimmunotherapy of human colon carcinoma by 131I‐labelled monoclonal anti‐cea antibodies in a nude mouse model

International Journal of Cancer

Volumn 41, Issue 1, 1988, Pages 127-134

  Buchegger, F ^a   Vacca, A ^b   Carrel, S ^a   Schreyer, M ^a   Mach, J P ^b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY I 131; CARCINOEMBRYONIC ANTIGEN; MONOCLONAL ANTIBODY I 131; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; COLON CARCINOMA; DRUG THERAPY; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUDE MOUSE; RADIOIMMUNOTHERAPY; RADIOTHERAPY; TUMOR XENOGRAFT;

ANIMAL; ANTIBODIES, MONOCLONAL; CARCINOEMBRYONIC ANTIGEN; CELL DIVISION; CELL LINE; COLONIC NEOPLASMS; HUMAN; IMMUNOGLOBULINS, FAB; IODINE RADIOISOTOPES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0023838640     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910410123     Document Type: Article

References (49)

1. 2 and Fab fragments in mice with colon carcinoma xenografts
2. 131I‐labeled anti‐T‐cell antibodies
3. Lysis of tumor cells by the retargeting of murine cytolytic T lymphocytes with bispecific antibodies
4. In vitro and in vivo tumor models for studies of distribution of radiolabelled monoclonal antibodies and fragments
5. Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice
6. Monoclonal antibodies identify a CEA crossreacting antigen of 95 kDa (NCA‐95) distinct in antigenicity and tissue distribution from the previously described NCA of 55 5Da
7. Swine monoclonal antibodies of high affinity and specificity to carcinoembryonic antigen
8. Comparison of the distribution and binding of monoclonal antibodies labeled with 131‐iodinc or 111‐indium
9. Monoclonal antibody and an antibody‐toxin conjugate to a cell surface proteoglycan of melanoma cells suppress in vivo tumor growth
10. D2‐specific monoclonal antibody against human neuroblastoma xenografted in nude mice
11. 2 fragments from monoclonal anti‐carcinoembryonic antigen antibodies
12. Preclinical trials with combinations and conjugates of T101 monoclonal antibody and doxorubicin
13. Inflammatory tumor response to monoclonal antibody infusion
14. Experimental radioimmunotherapy of a xenografted human colonic tumor (GW‐39) producing carcinoembryonic antigen
15. Effect of size of radiolabeled antibody and fragments on tumor uptake and distribution in nephrectomized mice
16. 111In‐labeled monoclonal antitumor antibodies in normal animals and nude mouse‐human tumor models
17. Monoclonal antibodies to carcinoemibryonic antigen: ionic strength as a factor in the selection of antibodies For immunoscintigraphy
18. Antitumor effects of L6, an IgG2a antibody that reads with most human carcinomas
19. IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells
20. D3 ganglio‐side: A phase I trial in patients with malignant melanoma
21. The physics of radiology
22. Therapeutic application of a radiolabelled monoclonal antibody in nude mice xenografted with human neuroblasioma: tumoricidal effects and distribution studies
23. Fusion between immunoglobulin‐secreting and nonsecreting myeloma cell lines
24. Continuous cultures of fused cells secreting antibody of predefined specificity
25. Covalent attachment of chelating groups to macromolecules
26. 2 fragments from mouse IgG of various subclasses
27. The use of hybrid hybridomas to target human cytotoxic T lymphocytes
28. Radiolabeled monoclonal anti‐tumor antibodies in diagnosis and therapy
29. 131I‐labeled P97‐specific Fab fragments in human melanoma as a basis for radiotherapy
30. Improved radioimmunolocalization of carcinomas using Fab fragments with anti‐CEA specificity
31. Use of radiolabeled monoclonal anti‐CEA antibodies for the detection of human carcinomas by external photoscaning and tomoscintigraphy
32. Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma
33. In vivo localization of radiolabeled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice
34. Carcinoemoryonic antigen production. secretion and kinetics in BALB/c mice and a nude mouse‐human tumor model
35. Treatment of B cell lymphoma with monoclonal anti‐idiotype antibody
36. 111In‐labeled monoclonal antibody 96.5
37. Monoclonal antibody therapy of malignant melanoma:, in vivo localization in cutaneous metastasis after intravenous administration
38. Radioimmunoglobulin therapy of cancer
39. The effect of tumor CEA content and tumor size on tissue uptake of indium 111‐labeled anti‐CEA monoclonal antibody
40. Localization of tumor associated antigens on sections of human colon carcinoma grafted into nude mice with mouse monoclonal antibodies using the avidin‐biotin‐immunoperoxidase reaction
41. Intratumor localization of monoclonal antibody in patients with melanoma treated with antibody to a 250,000‐Dalton melanoma‐associated antigen
42. Eradication of established human melanoma tumors in nude mice by antibody‐directed effector cells
43. Phase II clinical trial of a murine monoclonal antibody cytotoxic for gastrointestinal adenocarcinoma
44. Tissue distribution and serum kinetics of T101 monoclonal antibody during passive anti‐cancer therapy
45. Therapy of patients with malignant melanoma using a monoclonal antimelanoma antibody‐riein A Chain immunotoxin
46. Hybrid antibodies can target sites for attack by T cells
47. 2 and Fab fragments in human colon multicellular tumor spheroids
48. 131I‐labeled monoclonal antibodies