Drugs and the periodontium

Journal of Clinical Periodontology

Volumn 15, Issue 1, 1988, Pages 1-16

  Seymour, R A ^a   Heasman, P A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

gingival hyperplasia; periodontal destruction; Systemic drug therapy

Indexed keywords

CORTICOSTEROID; HORMONE; IMMUNOSUPPRESSIVE AGENT;

DRUG THERAPY; GINGIVA HYPERPLASIA; HUMAN; ORAL DRUG ADMINISTRATION; PERIODONTAL DISEASE; REVIEW; SIDE EFFECT;

ANIMAL; DRUG THERAPY; HUMAN; PERIODONTAL DISEASES; PERIODONTIUM; PHARMACOKINETICS; PHARMACOLOGY;

EID: 0023833918     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.1988.tb01549.x     Document Type: Review

References (209)

1. Phenytoin‐induced depression of salivary IgA and gingival hyperplasia
2. Phenytoin‐induced salivary IgA deficiency and gingival hyperplasia
3. Hyperplasia gingivae diphenylhydantoinea
4. Pregnancy gingivitis: a survey of 100 antenatal patients
5. Gingival hyperplasia associated with cycltosporin A. A report of two cases
6. Risk factors for postmenopausal osteoporosis
7. Incidence of diphenylhydantoin gingival hyperplasia
8. Diphenylhydantoin gingival hyperplasia. A clinicopathological review I. Incidence, clinical features and histopathology
9. Calcium channel blocking agents in the treatment of cardiovascular disorders Part I: Basic and clinical electrophysiologic effects
10. Histologic changes in the jaws and teeth of rats following nephritis, adrenalectomy and cortisone treatment
11. Glucocorticoid suppression of macrophage migration inhibitory factor
12. Steroid binding protein in human gingiva
13. The effects of immunosuppressive drugs on periodontal inflammation in human renal allograft patients
14. Gingival hyperplasia by nifedipine; report of a case
15. Cyclosporine‐induced gingival hyperplasia; case report and literature review
16. Immunosuppressive agents and allogenic transplantation
17. Cyclosporin A Clinical results
18. Effects of diphenylhydantoin on the transport of Na+ and K+ and the regulation of sugar transport in muscle in vitro
19. A new approach to the study of human B lymphocyte function using an indirect plaque assay and a direct B‐cell activator
20. Uremia as a state of immune deficiency
21. Macrocortin: a polypeptide causing the anti‐phospholipase effect of glucocorticoids
22. Effects of the new antilymphocyte peptide Cyclosporin A in animals
23. Transformation of arachidonic acid and homo‐y‐unoleic acid by rabbit polymorphonuclear leukocytes
24. Cyclosporin A in clinical organ grafting
25. Mouth manifestations and oral contraceptives
26. The effect of Dilantin on the cellular immune response to dento‐gingival plaque extract
27. Proposals for revised clinical and electroencephalographic classification of epileptic seisures
28. The relationship of 5, 5‐diphenylhydantoin metabolism to the species‐specific induction of gingival hyperplasia in the rat
29. Levels of 5,5‐diphenyl‐hydanioirt and its major metabolite in human serum, saliva and hyperplastic gingiva
30. Interaction between prostaglandin E and F given intradermally in the rat
31. Cyclosporine therapy its significance to the periodontist
32. Oral contraceptives and periodontal disease
33. Endocrine and metabolic diseases
34. Levels of PGE, thromboxane and prostacyclin in periodontal tissue
35. Suppression of macrophage arming by corticosteroids
36. Dilantin hyperplasia
37. Studies on the biology of the periodontium of marmosets, VIII The effect of folic acid deficiency on the marmoset oral mucosa
38. Oral Tissue reactions from Dilantin medication in the control of epileptic seizures
39. Prostaglandin‐like activity in ocular inflammation
40. Comparative study of the influence of pregnancy and oral contraceptives on the gingivae
41. −3 H. in vitro in human gingiva with periodontitis
42. −3 H‐androstenedione in normal and inflamed human gingiva
43. Comparative metabolism of female sex steroids in normal and chronically inflamed gingiva of the dog
44. Prostaglandins in gingiva of patients with periodontal disease
45. Hydroxy fatty acids and prostaglandin formation in diseased human periodontal pocket tissue
46. 34 C‐arachidonic acid by human gingival tissue in vitro
47. Arachidonic acid metabolism in inflamed gingiva and its inhibition by anti‐inflammatory drugs
48. 14C‐progesterone m normal and chronically inflamed human gingival tissue
49. Sodium Dilantin gingival hyperplasia
50. Non‐steroidal anti‐inflammatory drugs in the reduction of human alveolar bone loss
51. Indomethacin and aspirin abolish prostaglandin release from the spleen
52. Subcellular distribution of oxidative enzymes in human, inflamed and dilantin hyperplastic gingivae
53. Megaloblastic anaemia associated with anticonvulsant drugs
54. IgA deficiency, epilepsy and hydantoin medication
55. Leukotriene B: A biologically active release product of polymorphonuclear leukocytes
56. Activities of immunosuppressive agents in vitro
57. Blood levels of 17‐hydroxycorticosteroids in normal pregnancy
58. Enhanced NK cell activity in mice injected with interferon and interferon inducers
59. Glucocorticoid‐induced inhibition of T‐cell growth factor
60. Dental root abnormalities and gingival overgrowth in epileptic patients receiving anticonvulsant therapy
61. Inter relation of local and systemic factors in periodontal disease: bone factor concept
62. Hyperplasia of the gingivae associated with Dilantin (sodium diphenylhydantoinate) therapy
63. Modification of the effect of cortisone upon alveolar bone by the systemic administration of oestrogen
64. The steroid hormones and tissues of the periodontium
65. The effect of systemic administration of cortisone upon the periodontium of white mice
66. Effects of long‐term cortisone treatment on the supporting structures of the rat
67. Local action of steroids on senile human skin
68. A potential role of prostaglandins in the aetiology of periodontal disease
69. Biosynthesis of PGE; by gingival homogenates
70. Recovery of prostaglandins in human cutaneous inflammation
71. Effect of chronic anticonvulsant therapy on serum 25‐hydroxycalciferol levels in adults
72. Therapeutic effect of hydrocortisone on diseases affecting the oral mucosa
73. Progesterone metabolism in healthy and inflamed female gingiva
74. The production of a bone resorbing factor by dental cysts in vitro
75. Root abnormalities in epileptics and the inhibition of parathyroid hormone‐induced bone resorption by diphenylhydantoin in tissue cultures
76. Prostaglandin production and bone resorption by dental cysts
77. Carbamazepine and haematological monitoring
78. Phenytoin gingival overgrowth: rate of drug metabolism by fibroblasts
79. Phenytoin sensitivity of fibroblasts as the basis for susceptibility to gingival enlargement
80. Phenytoin induced gingival overgrowth in institutionalized epileptics
81. The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin
82. 2, levels
83. Flow of gingival exudate as related to menstruation and pregnancy
84. Prostaglandin biosynthesis in pulmonary macrophages
85. Gingival inflammation and female sex hormones
86. Macrophages synthesise and release prostaglandins in response to inflammatory stimuli
87. Clinical experiences with cortisone and ACTH in 5 cases of periodontal disease
88. The effects of hormones on the oral structures
89. Gingival hyperplasia associated with nifedipine (letter)
90. Diphenylhydantoin‐induced gingival hyperplasia; its relationship to dose and serum level
91. A clinical study of gingival inflammation in renal transplant recipients talking immunosuppressive drugs
92. An oral contraceptive as an aetiologic factor in producing hyperplastic gingivitis and a neoplasm of the pregnancy tumour type
93. Gingival hyperplasia during dilantin therapy; a survey of 312 patients
94. The effects of hormonal contraceptives on the human periodontium
95. Die Hydantoin‐Hyperplasie
96. Effect of the administration of steroid hormones on the gingival tissues
97. Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages
98. The effects of cortisone and induced local factors on the periodontium of the albino rat
99. Cyclosporin A permits the distinction between specific T and NK activity generated in human MLC
100. Hyperbilirubinemia and cyclosporin A levels
101. cyclosporin A: a powerful immunosuppressant
102. Gingival hyperplasia associated with nifedipine therapy. Report of a case
103. Gingival exudation during the menstrual cycle
104. Influence of sex hormones on gingival exudation in dogs with chronic gingivitis
105. The influence of progestogen and gingival exudation during menstrual cycles
106. Vascualr proliferation in pseudo‐pregnant rabbits
107. Influence of hormoal contraceptives on the gingiva of women
108. Changes in microcirculation after local application of sex hormones
109. Changes in vascular permeability after local application of sex hormones
110. The effect of sex hormones on vascularisation of granulation tissue
111. Changes in vascular proliferation after local application of sex hormones
112. Diphenylhydantoin inhibition of sodium conductance in the giant squid axon
113. Diphenylhydantoin‐induced gingival hyperplasia: its response to changes in drug dosage
114. Response of oral epithelia to ovariectomy and oestrogen replacement
115. Periodontal changes in pregnancy
116. Periodontal disease in pregnancy. I. Prevalence and severity
117. Prostaglandin E and the local immune response in chronic periodontal disease
118. Nifedipine‐induced gingival hyperplasia. A histochemical and ultrastructural study
119. ‘The Pill’ as an etiologic agent in hypertrophic gingivitis
120. Cellular bases of barbiturate and phenytoin anticonvulsant drug action
121. Diphenylhydantoin effects on human lymphocytes in vitro and in vivo
122. Gingivitis in pregnancy
123. Dilantin and folic acid status. Clinical implications for the periodontist
124. Biosynthesis of prostaglandins in gingiva of patients with chronic periodontitis
125. Role of the polymorphonuclear leukocyte in periodontal health and disease
126. The effect of the phenytoin metabolite p‐HPPH on proliferation of gingival fibroblasts in vitro
127. The microvasculature of the rabbit gingiva as affected by progesterone: an ultrastructural study
128. Prostaglandins. aspirin‐like drugs and the oedema of inflammation
129. Erkrankungen durch Arzneimittel im Mund‐und Kieferbereich
130. Bone resorbing activity of gingivae from beagle dogs following metranidazole and indomethacin therapy
131. Effects of estrogen on the gingiva and alveolar bone of molars in rats and mice
132. Studies on the influence of estradiol and progesterone on granulation tissue
133. Suppression of inflammation and bone resorption by indomethacin during experimental periodontitis in dogs
134. Crevicular fluid PGE levels as a measure of the periodontal disease status of adult and juvenile periodontitis patients
135. The use of crevicular fluid PGE: levels as a predictor of periodontal attachment loss
136. Testosterone metabolism in chronically inflamed male gingival tissue
137. Progesterone metabolism by rat oral mucosa, II, The effect of pregnancy
138. Periodontal status of patients with reduced immunocapacity
139. Pathogenesis of inflammatory periodontal disease
140. Current status of the host response in chronic marginal gingivitis
141. The effect of anticonvulsant drugs upon the gingiva ‐ a series of analyses of 1048 patients. Part 1
142. Mechanisms of glucocorticoid action on immune processes
143. Serum diphenylhydantoin levels following a change in drug brand
144. An oral contraceptive drug and gingival enlargement; the relationship between local and systemic factors
145. Diphenylhdantoin and ion flux in lobster nerve
146. Increased unbound cortisol in the plasma of estrogen‐treated subjects
147. Gingival hyperplasia caused by nifedipine‐a preliminary report
148. Initial observations that cyclosporin‐A induces gingival enlargement in man
149. Clinical pharmacokinetics of phenytoin
150. Effect of prostaglandin E: on macrophages and osteoclasts in cultured foetal long bones
151. Periodontal status and pregnancy
152. The effects of diphenylhydantoin and vitamin D deficiency on developing teeth in the rat
153. Transcortin: A corticosteroid‐binding protein of plasma. X. Cortisol and progesterone interplay and unbound levels of these steroids in pregnancy
154. Severe gingival overgrowth associated with cyclosporin therapy
155. Histological quantification of the biological effects of estradiol benzoate on the gingiva and genital mucosa of castrated rabbits
156. Corticosteroid therapy and periodontal disease
157. Biosynthesis of prostaglandins
158. Prostaglandins, thromboxanes and teukotrienes: formation and biological roles
159. The effect of intravenous estrogens on ground substance
160. Periodontal status of renal transplant patients receiving immunosuppressive therapy
161. Diphenylhdantoin: excitability reducing action in single myelinated nerve fibers
162. IgA deficiency. epilepsy and phenytoin treatment
163. The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients ‐ a longitudinal study
164. The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients
165. Formation of l2L‐hyclroxyeicosatetraenoic acid (12‐HETE) by gingival tissue
166. Aspirin selectively inhibits prostaglandin production in human platelets
167. T‐cell growth factor
168. Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin)
169. Oral contraceptive hypertrophic gingivitis
170. Effects of long term anticonvulsant therapy on calcium and vitamin D metabolism
171. Action of diphenylhydantoin sodium on the adrenal gland
172. Diphenylhydantoin, adrenal function and epilepsy
173. Liver transplantation with use of cyclosporin A and prednisone
174. Effects of corticol hormones in the treatment of periodontal disease
175. Cross‐sectional study of the effects of immunosuppressive drugs on chronic Periodontal disease in man
176. 1
177. Calcium balance in osteoporotic patients on long‐term oral calcium therapy with and without sex hormones
178. The effect of immunosuppressive agents on periodontal disease in man
179. Immunosuppression and periodontal disease in man. Histological and ultrastructural observations
180. Neuropharmacology of peripheral nerve
181. An histological investigation into keratinisation found in human gingivae
182. Gingival hyperplasia induced by cyclosporin‐A
183. Gingival hyperplasia induced by nifedipine, an arterial vasodilating drug
184. Inhibition of prastaglandin synthesis as a mechanism of action for aspirin‐like drugs
185. Prostaglandins as mediators of inflammation
186. Concentration of circulating hormones and metabolism of androgens by human gingiva
187. Effect of plasma progesterone on 4‐3‐kelosteroid‐5α‐reductase activity in human gingiva and its biological significance
188. Gingival hyperplasia and folic acid deficiency from anticonvulsive drug therapy: a theoretical relationship
189. Relationship of folic acid to phenytoin induced gingival overgrowth
190. The effects of a topically active non‐steroidal anti‐inflammatory drug on ligature‐induced periodontal disease in the squirrel monkey
191. The periodontal status of subjects receiving non‐steroidal anti‐inflammatory drugs
192. The chemo suppression of chemotaxis
193. Effects of endocrine secretions
194. Drugs, toxins and dietary amino acids affecting Bu and folic acid absorption or utilization
195. The effect of indomethacin on alveolar bone loss in experimental periodontitis
196. Mechanism of cortisol inhibition of adoptive transfer of tuberculin sensitivity
197. Flurbiprofen ‐ a potent inhibitor of alveolar bone resorption in beagles
198. Prostaglandins as potentiators of increased vascular permeability in inflammation
199. Role of prostaglandin‐mediated vasodilatation in inflammation
200. 2a and PGE, on vascular permation
201. Metabolism of arachidonic acid in inflamed human gingiva 1; Formation of 6‐keto PGF1α
202. Antiepileptic drugs; mechanisms of action
203. Fibrous hyperplasia of the gingiva; a side effect of cyclosporin A therapy
204. Effects of subcutaneous injections of estrogenic and gonadotrophic hormones on gums and oral mucous membranes of normal and castrated rhesus monkeys
205. Pregnancy gingivitis
206. Prostaglandin release from human polymorphonuclear leukocytes