Quantitative evaluation of the properties of a pyridazinyl GABA derivative (SR 95531) as a GABAA competitive antaginist. An electrophysiological approach

Brain Research

Volumn 442, Issue 2, 1988, Pages 287-296

  Hamann, M ^a   Desarmenien, M ^a   Desaulles, E ^a   Bader, M F ^b   Feltz, P ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b CENTRE DE NEUROCHIMIE   (France)

Author keywords

Calcium current; Chloride channel; Chromaffin cell; GABAA antagonist; Pyridazine derivative; Sensory ganglion; Aminobutyric acid (GABA)

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; CALCIUM;

ANIMAL CELL; CATTLE; CELL CULTURE; CHLORIDE CHANNEL; CHROMAFFIN CELL; INTRACELLULAR RECORDING; NONHUMAN; SENSORY GANGLION;

ADRENAL MEDULLA; ANIMAL; BINDING, COMPETITIVE; CALCIUM; CATTLE; CELL MEMBRANE; CELLS, CULTURED; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GANGLIA, SPINAL; ION CHANNELS; KINETICS; MEMBRANE POTENTIALS; NEURONS; PYRIDAZINES; RECEPTORS, GABA-A; SUPPORT, NON-U.S. GOV'T;

EID: 0023833116     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(88)91514-4     Document Type: Article

References (26)

1. Characterization of hormone and protein release from α-toxin-permeabilized chromaffin cells in primary culture
2. γ-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study
3. Depolarization elicits two distinct calcium currents in vertebrate sensory neurones
4. Inactivation of the low-threshold transient calcium current in rat sensory neurones: evidence for a dual process
5. A receptor site
6. Convulsant doses of penicillin shorten the lifetime of GABA-induced channels in cultured central neurones
7. Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate
8. Fitting and statistical analysis of single-channel records
9. B responses
10. B receptors on Aδ and C primary afferents
11. Effect of internal calcium concentration on calcium currents in rat sensory neurones
12. Sodium and Calcium channels in bovine chromaffin cells
13. Modulation of calcium channels by norepinephrine in internally dialysed avian sensory neurons
14. The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory
15. Pyridazinyl-GABA derivatives as GABA and glycine antagonists in the spinal cord of the cat
16. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches
17. Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABA-A receptor site
18. A receptor antagonist activity to rat brain
19. A receptor for protons in the nerve cell membrane
20. Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium
21. Interaction of three pyridazinyl-GABA derivatives with rat central GABA and glycine receptors, an in vivo microiontophoretic study
22. Multiple calcium channels and neuronal function
23. Three types of neuronal calcium channel with different calcium agonist sensitivity
24. A antagonists
25. Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of γ-aminobutyric acid acting as selective GABA-A antagonists