Kinetics and mechanisms of the autoxidation of ketorolac tromethamine in aqueous solution

International Journal of Pharmaceutics

Volumn 41, Issue 1-2, 1988, Pages 95-104

  Leo, Gu ^a   Hi Shi, Chiang ^a   Becker, Allyn ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

Autoxidation; Degradation product; Ketorolac tromethamine; Kinetics; Mechanism; Stability

Indexed keywords

KETOROLAC TROMETAMOL;

DRUG MECHANISM; DRUG STABILITY; METHODOLOGY; NONHUMAN; PRELIMINARY COMMUNICATION;

EID: 0023832501     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(88)90141-X     Document Type: Article

References (19)

1. An electron spin resonance study of fatty acids and esters Part 2 Hydrogen abstraction from saturated acids and their derivatives
2. RS-37619 and aspirin analgesia for post-partum uterine cramps
3. The Isomerization of Ketorolac Tromethamine
4. Autoxidation of ketones and esters in basic solution
5. Homogeneous Liquid-Phase Autoxidations
6. Stability of Parenterals
7. Syntheses and antiinflammatory and analgesic activity of 5-aroy1-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and related compounds
8. Review of glass types available for packaging parenteral solutions
9. Prediction of drug stability Part 3: oxidation and photolytic degradation
10. Acidity of hydrocarbons
11. Analgesia from intramuscular ketorolac tromethamine compared to morphine (MS) in “severe” pain following “major” surgery
12. The analgesic efficacy of (±)-5-benzoyl-1,2-dihydro-3H-pyrrole[1,2a]pyrrole-1-carboxylic acid, tromethamine salt (B) in post-operative pain