Complete Resolution of Pure Red Cell Aplasia in a Patient With Chronic Lymphocytic Leukemia Following Antithymocyte Globulin Therapy

JAMA: The Journal of the American Medical Association

Volumn 259, Issue 5, 1988, Pages 723-725

  Radosevich, Cynthia A ^a   Gordon, Leo I ^c   Weil, Susan C ^a   Marder, Robert J ^b   Rosen, Steven T ^a  

^a Section Hematology/Oncology   (United States)

^b Departments of Pathology   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPREDNISOLONE SODIUM SUCCINATE; THYMOCYTE ANTIBODY;

AGED; B CELL LEUKEMIA; CASE REPORT; CHRONIC LYMPHATIC LEUKEMIA; ERYTHROCYTE APLASIA; HUMAN; MALE; PRIORITY JOURNAL;

AGED; ANTILYMPHOCYTE SERUM; B-LYMPHOCYTES; CASE REPORT; COMBINED MODALITY THERAPY; HUMAN; LEUKEMIA, LYMPHOCYTIC; MALE; METHYLPREDNISOLONE HEMISUCCINATE; RED-CELL APLASIA, PURE; T-LYMPHOCYTES;

EID: 0023830169     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1988.03720050059024     Document Type: Article

References (12)

1. Berlin NI, Lawrence JH, Lee HC: The pathogenesis of anemia of chronic leukemia: Measurement of life span of the red blood cell with glycine2-C14. J Lab Clin Med 1954;44:860-874.
2. Mangan KF, D’Alessandro L: Hypoplastic anemia in B cell chronic lymphocytic leukemia: Evolution of T-cell mediated suppression of erythropoiesis in early-stage and late-stage disease. Blood 1985;66:533-541.
3. Mangan KF, Chikkappa G, Farley PC: T gamma (Tγ) cells suppress growth of erythroid colony-forming units in vitro in pure red cell aplasia of B-cell chronic lymphocytic leukemia. J Clin Invest 1982;70:1148-1156.
4. Chikkappa G, Zarragi MH, Tsan M: Pure red cell aplasia in patients with chronic lymphocytic leukemia. Medicine 1986;65:339-351.
5. Chikkappa G, Pasquale D, Mangan K, et al.: Successful treatment of pure red cell aplasia (PRCA) in a patient with chronic lymphocytic leukemia (CLL) with cyclosporin-A, abstracted. Blood 1986;68(suppl 1):106.
6. Mangan KF, Shadduck RK: Successful treatment of chronic refractory pure red cell aplasia with antithymocyte globulin: Correlation with in vitro erythroid culture studies. Am J Hematol 1984;17:417-426.
7. Harris SI, Weinberg JB: Treatment of red cell aplasia with antithymocyte globulin: Repeated inductions of complete remissions in two patients. Am J Hematol 1985;20:183-186.
8. Mangan KF, Ruszkowski RJ: Erythropoietic response to horse anti-human thymocyte globulin in the red cell aplasia of B-cell chronic lymphocytic leukemia, abstracted. Blood 1985;66(suppl 1)121.
9. Mangan KF, Chikkappa G, Bieler LZ, et al.: The role of T lymphocytes bearing Fc receptors for IgM or IgG in the pathogenesis of pure red cell aplasia in a patient with chronic lymphocytic leukemia, in Karger AG, Baum SJ, Ledney GD, Khan A (ed): Experimental Hematology Today. Basel, Switzerland, 1981, pp 161-168.
10. Hunter RF, Roth PA, Huang AT: Predictive factors for response to anti-thymocyte globulin in acquired aplastic anemia. Am J Med 1985;79:73-79.
11. Gascon P, Zoumbos NC, Scala G, et al.: Lymphokine abnormalities in aplastic anemia: Implications for the mechanism of action of antithymocyte globulin. Blood 1985;65:407-413.
12. Mangan KF, D’Alessandro L, Mullaney MT: Action of anti-thymocyte globulin on normal human erythroid progenitor cell proliferation in vitro: Erythropoietic growth-enhancing factors are released from marrow accessory cells. J Lab Clin Med 1986;107:353-364.