Autoradiographic Analysis of [3H]Imipramine Binding in the Human Brain Postmortem: Effects of Age and Alcohol

Journal of Neurochemistry

Volumn 51, Issue 2, 1988, Pages 528-534

  Gross‐Isseroff, Ruth ^a   Biegon, Anat ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Autoradiography; Human brain; Imipramine

Indexed keywords

ALCOHOL; IMIPRAMINE; BRAIN RECEPTOR; DRUG RECEPTOR; RADIOISOTOPE;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN; HUMAN; METABOLISM; TISSUE DISTRIBUTION; AGE; AUTOPSY; BRAIN REGION; DRUG BINDING SITE; HUMAN CELL; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; AUTORADIOGRAPHY; BINDING SITES; BRAIN; ETHANOL; HUMAN; IMIPRAMINE; MIDDLE AGE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; TISSUE DISTRIBUTION;

EID: 0023820408     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1988.tb01070.x     Document Type: Article

References (38)

1. Biochemical evidence of selective nerve cell changes in the normal ageing human and rat brain
2. The primate serotonergic system: a review of human and animal studies and a report on Macaca fascicularis
3. Distribution of imipramine binding sites in the rat brain studied by quantitative autoradiography
4. 3H]desmethylimipramine binding sites in rat brain by quantitative autoradiography
5. Binding of a labeled antidepressant to rat brain tissue
6. Biogenic amines in human brain in normal aging, senile dementia and chronic alcoholism
7. 3H]imipramine binding sites in controls and Parkinsonian brains
8. Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer‐type dementia and depression, and suicides
9. Structure of the Human Brain
10. Aging of the cholinergic system: comparative autoradiography of muscarinic receptors in young and aged rat brain. (Abstr)
11. 3H‐Imipramine binding sites in rat brain: selective localization on serotonergic neurone.
12. Concentration of protein substances in neurons of different areas of the cerebral cortex in alcoholic delirium
13. Quantitative mapping by autoradiography: some current technical problems
14. 3H‐imipramine binding in human platelets
15. 3H]imipramine in human brain
16. Effect of age on human brain serotonin (S‐l) binding sites
17. Regional brain levels of monoamines in alcohol‐preferring and ‐nonpreferring lines of rats
18. Monoamine and metabolite levels in CNS regions of the P line of alcohol‐preferring rats after acute and chronic ethanol treatment
19. Contents of monoamines in forebrain regions of alcohol‐preferring (P) and ‐nonpreferring (NP) lines of rats
20. 3H]imipramine in rat brain
21. 3H‐imipramine binding label serotonin uptake sites in brain and platelets
22. High affinity binding of antidepressants to a biogenic amine transport site in human brain and platelet: studies in depression
23. Decreased imipramine binding in the brains of patients with depressive illness
24. Autoradiographic localization of imipramine binding in rat brain
25. Quantitative autoradiography with tritium‐labeled ligands: comparison of biochemical and densitometric measurement
26. Specific tricyclic antidepressant binding sites in rat brain
27. 3H‐imipramine binding
28. 3H]‐imipramine in human brain
29. Localization of tricyclic antidepressant binding sites on serotonin nerve terminals
30. 3H‐Imipramine binding in aged mouse brain: regulation by ions and serotonin
31. 3H]imipramine binding in aged human brain
32. Tritiated imipramine binding sites are decreased in the frontal cortex of suicides
33. Problems and promises of postmortem brain tissue analysis
34. Age alters the observed response of imipramine binding sites to chronic antidepressant treatment in female rats
35. Chronic ethanol inhibits rat hippocampal “stimulus‐secretion” coupling mechanism for 5‐hydroxytryptamine in vitro