Physical Fitness as a Predictor of Cardiovascular Mortality in Asymptomatic North American Men

New England Journal of Medicine

Volumn 319, Issue 21, 1988, Pages 1379-1384

  Ekelund, Lars Göran ^a   Haskell, William L ^b   Johnson, Jeffrey L ^a   Whaley, Fredrick S ^a   Criqui, Michael H ^c   Sheps, David S ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANADA; CARDIOVASCULAR RISK; CORONARY ARTERY DISEASE; FITNESS; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; UNITED STATES;

ADULT; AGED; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CORONARY DISEASE; FOLLOW-UP STUDIES; HEART RATE; HUMAN; MALE; MIDDLE AGE; PHYSICAL FITNESS; PROGNOSIS; RISK FACTORS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023815569     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198811243192104     Document Type: Article

References (40)

1. Morris JN, Everitt MG, Pollard R, Chave SPW, Semmence AM. Vigorous exercise in leisure-time: protection against coronary heart disease. Lancet 1980; 2: 1207–10.
2. Paffenbarger RS Jr, Hale WE. Work activity and coronary heart mortality. N Engl J Med 1975; 292: 545–50.
3. Paffenbarger RS Jr, Wing AL, Hyde RT. Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol 1978; 180: 161–75.
4. Siscovick DS, Weiss NS, Hallstrom AP, Inui TS, Petersen DR. Physical activity and primary cardiac arrest. JAMA 1982; 248: 3113–7.
5. Ekblom B. Effect of physical training on oxygen transport system in man. Acta Physiol Scand 1969; 328: Suppl: 9–45.
6. Leon AS, Jacobs DR Jr, DeBacker G, Taylor HL. Relationship of physical characteristics and life habits to treadmill exercise capacity. Am J Epidemiol 1981; 113: 653–60.
7. Folsom AR, Caspersen CJ, Taylor HL, et al. Leisure time physical activity and its relationship to coronary risk factors in a population-based sample: the Minnesota Heart Survey. Am J Epidemiol 1985; 121: 570–9.
8. Crow RS, Rautaharju PM, Prineas JR, et al. Risk factors, exercise fitness and electrocardiographic response to exercise in 12,866 men at high risk of symptomatic coronary heart disease. Am J Cardiol 1986; 57: 1075–82.
9. Schwane JA, Cundiff DE. Relationships among cardiorespiratory fitness, regular physical activity, and plasma lipids in young adults. Metabolism 1979; 28: 771–8.
10. Gordon DJ, Leon AS, Ekelund LG, et al. Smoking, physical activity, and other predictors of endurance and heart rate response to exercise in asymptomatic hypercholesterolemic men: the Lipid Research Clinics Coronary Primary Prevention Trial. Am J Epidemiol 1987; 125: 587–600.
11. Peters RK, Cady LD Jr, Bischoff DP, Bernstein L, Pike MC. Physical fitness and subsequent myocardial infarction in healthy workers. JAMA 1983; 249: 3052–6.
12. Lie H, Mundal R, Erikssen J. Coronary risk factors and incidence of coronary death in relation to physical fitness: seven-year follow-up study of middle-aged and elderly men. Eur Heart J 1985; 6: 147–57.
13. Sobolski J, Kornitzer M, De Backer G, et al. Protection against ischemic heart disease in the Belgian Physical Fitness Study: physical fitness rather than physical activity? Am J Epidemiol 1987; 125: 601–10.
14. Haskell WL, Taylor HL, Wood PH, Schrott H, Heiss G. Strenuous physical activity, treadmill exercise test performance and plasma high-density lipoprotein cholesterol: the Lipid Research Clinics Program Prevalence Study. Circulation 1980; 62: Suppl IV: IV-53-IV-61.
15. Sheffield LT, Haskell W, Heiss G, et al. Safety of exercise testing volunteer subjects: the Lipid Research Clinics' Prevalence Study experience. J Cardiac Rehab 1982; 2: 395–400.
16. Sheffield LT, Roitman D. Stress testing methodology. Prog Cardiovasc Dis 1976; 19: 33–49.
17. Gordon DJ, Ekelund LG, Karon JM, et al. Predictive value of the exercise tolerance test for mortality in North American men: the Lipid Research Clinics Mortality Follow-up Study. Circulation 1986; 74: 252–61.
18. Cox DR. Regression models and life-tables. J R Stat Soc [B] 1972; 34: 187–220.
19. SAS Institute, Inc. SUGI supplemental library user's guide. Version 5 ed. Cary, N.C.: SAS Institute, 1986.
20. Heaton WH, Marr KC, Capurro NL, Goldstein RE, Epstein SE. Beneficial effect of physical training on blood flow to myocardium perfused by chronic collaterals in the exercising dog. Circulation 1978; 57: 575–81.
21. Wyatt HL, Mitchell J. Influences of physical conditioning and deconditioning on coronary vasculature of dogs. J Appl Physiol 1978; 45: 619–25.
22. McElroy CL, Gissen SA, Fishbein MC. Exercise-induced reduction in myocardial infarct size after coronary artery occlusion in the rat. Circulation 1978; 57: 958–62.
23. Kramsch DM, Aspen AJ, Abramowitz BM, Kreimendahl T, Hood WB Jr. Reduction of coronary atherosclerosis by moderate conditioning exercise in monkeys on an atherogenic diet. N Engl J Med 1981; 305: 1483–9.
24. Noakes TD, Higginson L, Opie LH. Physical training increases ventricular fibrillation thresholds of isolated rat hearts during normoxia, hypoxia and regional ischemia. Circulation 1983; 67: 24–30.
25. Hanson JS, Tabakin BS, Levy AM, Nedde W. Long-term physical training and cardiovascular dynamics in middle-aged men. Circulation 1968; 38: 783–99.
26. Clausen JP. Circulatory adjustments to dynamic exercise and effect of physical training in normal subjects and in patients with coronary artery disease. Prog Cardiovasc Dis 1976; 18: 459–95.
27. Scheuer J, Tipton CM. Cardiovascular adaptations to physical training. Annu Rev Physiol 1977; 39: 221–51.
28. Ekelund LG. Exercise, including weightlessness. Annu Rev Physiol 1969; 31: 85–116.
29. Ferguson RJ, Cote P, Gauthier P, Bourassa MG. Changes in exercise coronary sinus blood flow with training in patients with angina pectoris. Circulation 1978; 58: 41–7.
30. Nolewajka AJ, Kostuk WJ, Rechnitzer PA, Cunningham DA. Exercise and human collateralization: an angiographic and scintigraphic assessment. Circulation 1979; 60: 114–21.
31. Knight DR, Stone HL. Alteration of ischemic cardiac function in normal heart by daily exercise. J Appl Physiol 1983; 55: 52–60.
32. Cox ML, Bennett JB III, Dudley GA. Exercise training-induced alterations of cardiac morphology. J Appl Physiol 1986; 61: 926–31.
33. Detry J-M, Bruce RA. Effects of physical training on exertional ST-segment depression in coronary heart disease. Circulation 1971; 44: 390–6.
34. Ehsani AA, Heath GW, Hagberg JM, Sobel BE, Holloszy JO. Effects of 12 months of intense exercise training on ischemic S-T-segment depression in patients with coronary artery disease. Circulation 1981; 64: 1116–24.
35. Ehsani AA, Biello D, Seals DR, Austin MB, Schultz J. The effect of left ventricular systolic function on maximal aerobic exercise capacity in asymptomatic patients with coronary artery disease. Circulation 1984; 70: 552–60.
36. Kopitsky RG, Switzer ME, Williams RS, McKee PA. The basis for the increase in factor VIII procoagulant activity during exercise. Thromb Haemost 1983; 49: 53–7.
37. Williams RS, Logue EE, Lewis JL, et al. Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults. N Engl J Med 1980; 302: 987–91.
38. Meade TW, Mellows S, Brozovic M, et al. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986; 1: 533–7.
39. Rauramaa R, Salonen JT, Seppanen K, et al. Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men. Circulation 1986; 74: 939–44.
40. Rauramaa R, Salonen JT, Kukkonen-Harjula K, et al. Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid: a controlled randomised trial in middle aged men. Br Med J 1984; 288: 603–6.