In vivo stimulation and restoration of the immune response by the noninflammatory fragment 163-171 of human interleukin 1β

Journal of Experimental Medicine

Volumn 168, Issue 2, 1988, Pages 675-686

  Boraschi, Diana ^a   Nencioni, Luciano ^a   Villa, Luigi ^a   Censini, Stefano ^a   Bossu, Paola ^a   Ghiara, Paolo ^a   Presentini, Rivo ^a   Perin, Fabio ^a   Frasca, Daniela ^b   Doria, Gino ^b   Forni, Guido ^c   Musso, Tiziana ^c   Giovarelli, Mirella ^c   Ghezzi, Pietro ^d   Bertini, Riccardo ^d   Besedovsky, Hugo O ^e   Del Rey, Adriana ^e   Sipe, Jean D ^f   Antoni, Guido ^a   Silvestri, Sergio ^a   Tagliabue, Aldo ^a   more..

^a CHIRON VACCINES   (Italy)

^b ENEA C R CASACCIA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e Schweizerisches Forschungsinstitut ^*  (Switzerland)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA[163-171];

ANIMAL; ANIMAL EXPERIMENT; DRUG THERAPY; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOSTIMULATION; IMMUNOTHERAPY; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION RESPONSE;

7-ALKOXYCOUMARIN O-DEALKYLASE; ADRENALECTOMY; ANIMAL; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HORMONES; IMMUNIZATION; INTERLEUKIN-1; LIVER; MALE; MICE; MICE, INBRED STRAINS; NEOPLASMS, EXPERIMENTAL; OXYGENASES; SHOCK; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0023810770     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.168.2.675     Document Type: Article

References (40)

1. Dinarello, C. A. 1984. Interleukin-1. Rev. Infect. Dis. 6: 51.
2. Dinarello, C. A. 1984. Interleukin-1 and the pathogenesis of the acute-phase response. N. Engl. J. Med. 311: 1413.
3. Besedovsky, H., A. del Rey, E. Sorkin, and C. A. Dinarello. 1986. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science (Wash. DC). 233: 652.
4. del Rey, A., and H. Besedovsky. 1987. Interleukin 1 affects glucose homeostasis. Am. J. Physiol. 22:R794.
5. Ghezzi, P., B. Saccardo, P. Villa, V. Rossi, M. Bianchi, and C. A. Dinarello. 1986. Role of interleukin-1 in the depression of liver drug metabolism by endotoxin. Infect. Immun. 54: 837.
6. Wood, D. D. 1985. Interleukin-1 in arthritis. In Inflammatory Mediators. G. A. Higgs and T. J. Williams, editors. MacMillan Press Ltd., Houndmills. 183-201.
7. Pujol, J. -P., and G. Loyau. 1987. Interleukin-1 and osteoarthritis. Life Sci. 41: 1187.
8. Smith, K. A., L. B. Lachman, J. J. Oppenheim, and M. F. Favata. 1980. The functional relationship of the interleukins. J. Exp. Med. 151: 1551.
9. Lowenthal, J. W., J. -C. Cerottini, and H. R. MacDonald. 1986. Interleukin 1-dependent induction of both interleukin 2 secretion and interleukin 2 receptor expression by thymoma cells. J. Immunol. 137: 1226.
10. Ho, S. N., R. T. Abraham, A. Nilson, B. S. Handwerger, and D.J. McKean. 1987. Interleukin 1-mediated activation of interleukin 4 (IL 4)-producing T lymphocytes. Proliferation by IL 4-dependent and IL 4-independent mechanisms. J. Immunol. 139: 1532.
11. Lipsky, P. E. 1985. Role of interleukin-1 in human B-cell activation. Contemp. Top. Mol. Immunol. 10: 195.
12. Booth, R. J., R. L. Prestidge, and J. D. Watson. 1985. Interleukin 1 and B cell responsiveness. Lymphokines. 12: 75.
13. Pike, B. L., and G.J. V. Nossal. 1985. Interleukin 1 can act as a B-cell growth and differentiation factor. Proc. Natl. Acad. Sci. USA. 82: 8153.
14. Moore, M. A. S., and D. J. Warren. 1987. Synergy of interleukin 1 and granulocyte colony-stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc. Natl. Acad. Sci. USA. 84: 7134.
15. Staruch, M. J., and D. D. Wood. 1983. The adjuvanticity of interleukin 1 in vivo. J. Immunol. 130: 2191.
16. Durum, S. K., C. Higuchi, and Y. Ron. 1984. Accessory cells and T cell activation. The relationship between two components of macrophage accessory cell function: I-A and IL 1. Immunobiology. 168: 213.
17. Nencioni, L., L. Villa, A. Tagliabue, G. Antoni, R. Presentini, F. Perin, S. Silvestri, andD. Boraschi. 1987. In vivo immunostimulating activity of the 163-171 peptide of human IL-ip.J. Immunol. 139: 800.
18. Nencioni, L., L. Villa, A. Tagliabue, and D. Boraschi. 1987. Adjuvant activity of the 163-171 peptide of human IL-lβ administered through different routes. Lymphokine Res. 6: 335.
19. Ozaki, Y., T. Ohashi, A. Minami, and S. -I. Nakamura. 1987. Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin-1 a. Infect. Immun. 55: 1436.
20. Czuprynski, C. J., and J. F. Brown. 1987. Recombinant murine interleukin-1 a enhancement of nonspecific antibacterial resistance. Infect. Immun. 55: 2061.
21. Nakamura, S., K. Nakata, S. Kashimoto, H. Yoshida, and M. Yamada. 1986. Antitumor effect of recombinant human interleukin 1 alpha against murine syngeneic tumors. Gann. 77: 767.
22. Neta, R., S. Douches, and J. J. Oppenheim. 1986. Interleukin 1 is a radioprotector. J. Immunol. 136: 2483.
23. Rosenwasser, L. J., A. C. Webb, B. D. Clark, S. Irie, L. Chang, C. A. Dinarello, L. Gehrke, S. M. Wolff, A. Rich, and P. E. Auron. 1986. Expression of biologically active human interleukin 1 subpeptides by transfected simian COS cells. Proc. Natl. Acad. Sci. USA. 83: 5243.
24. De Chiara, T. M., D. Young, R. Semionow, A. S. Stern, C. Batula-Bernardo, C. Fiedler-Nagy, K. L. Kaffka, P. L. Kilian, S. Yamazaki, S. B. Mizel, and P. T. Lomedico. 1986. Structure-function analysis of murine interleukin 1: biologically active polypeptides are at least 127 amino acids long and are derived from the carboxyl terminus of a 270-amino acid precursor. Proc. Natl. Acad. Sci. USA. 83: 8303.
25. Zurawski, S. M., K. Pope, H. Cherwinski, and G. Zurawski. 1986. Expression in Escherichia coli of synthetic human interleukin-la genes encoding the processed active protein, mutant proteins, and p-galactosidase fusion proteins. Gene (Amst.). 49: 61.
26. Antoni, G., R. Presentini, F. Perin, A. Tagliabue, P. Ghiara, S. Censini, G. Volpini, L. Villa, and D. Boraschi. 1986. A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity. J. Immunol. 137: 3201.
27. Palaszynski, E. W. 1987. Synthetic C-terminal peptide of IL-1 functions as a binding domain as well as an antagonist for the IL-1 receptor. Biochem. Biophys. Res. Commun. 147: 204.
28. Mosley, B., S. K. Dower, S. Gillis, and D. Cosman. 1987. Determination of the mininum polypeptide lengths of the functionally active sites of human interleukins la and lp. Proc. Natl. Acad. Sci. USA. 84: 4572.
29. Cunningham, A. J., and A. Szenberg. 1968. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 14: 599.
30. Frasca, D., L. Adorini, S. Landolfo, and G. Doria. 1985. Enhancing effect of IFN-y on helper T cell activity and IL 2 production. J. Immunol. 134: 3907.
31. Carbone, G., M. P. Colombo, M. L. Sensi, A. Cernuschi, and G. Parmiani. 1983. In vitro detection of cell-mediated immunity to individual tumor-specific antigens of chemically induced BALB/c fibrosarcomas. Int. J. Cancer. 31: 483.
32. Forni, G., M. Giovarelli, A. Santoni, A. Modesti, and M. Forni. 1987. Interleukin 2 activated tumor inhibition in vivo depends on the systemic involvement of host immunoreac-tivity. J. Immunol. 138: 4033.
33. Duff, G. W., and S. K. Durum. 1983. The pyrogenic and mitogenic actions of interleukin-1 are related. Nature (Lond.). 304: 449.
34. Wycoff, H. D. 1970. Production of fibrinogen following an endotoxin injection. Proc. Soc. Exp. Biol. Med. 133: 940.
35. Sipe, J. D., T. F. Ignaczak, P. S. Pollock, and G. G. Glenner. 1976. Amyloid fibril protein AA: purification and properties of the antigenically related serum component as determined by solid phase radioimmunoassay. J. Immunol. 116: 1151.
36. Greenlee, W. F, and A. Poland. 1978. An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.y. Pharmacol. Exp. Ther. 205: 596.
37. Bertini, T., M. Bianchi, and P. Ghezzi. 1988. Andrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor. J. Exp. Med. 167: 1708.
38. Steel, R. G. D., and J. H. Torrie. 1960. Principles and Procedures of Statistics. McGraw-Hill Book Co., New York. 481 pp.
39. Snedecor, G. W. 1962. Statistical Methods Applied to Agriculture and Biology. The Collegiate Press, Ames, IA. 534 pp.
40. Mihich, E., and A. Fefer, editors. 1983. Biological response modifiers: subcommittee report. Natl. Cancer Inst. Monogr. 63: 1.