Iron Inhibits the Nonspecific Tumoricidal Activity of Macrophages: A Possible Contributory Mechanism for Neoplasia in Hemochromatosis

Annals of the New York Academy of Sciences

Volumn 526, Issue 1, 1988, Pages 301-309

  Green, Ralph ^a   Esparza, Inmaculada ^b   Schreiber, Robert ^c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON;

ANTINEOPLASTIC ACTIVITY; HEMOCHROMATOSIS; HUMAN; MACROPHAGE; PRIORITY JOURNAL;

ANIMAL; APOFERRITIN; COMPARATIVE STUDY; CYTOTOXICITY TESTS, IMMUNOLOGIC; DEPRESSION, CHEMICAL; HEMOCHROMATOSIS; INTERFERONS; IRON; LIPOSOMES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED DBA; PHAGOCYTOSIS; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0023803172     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1988.tb55514.x     Document Type: Article

References (22)

1. Long term results of venesection therapy in idiopathic haemochromatosis
2. Iron overload
3. Macrophage activation for tumor cytotoxicity: Development of macrophage cytotoxic activity requires completion of a sequence of short‐lived intermediary reactions
4. Characterization of the effects of endotoxin on macrophage‐tumor cell killing
5. Activation of mouse macrophages for tumor cell killing. I. Quantitative analysis of interactions between lymphokine and lipopolysaccharide
6. Macrophage activation for tumor cytotoxicity: Characterization of priming and trigger signals during lymphokine activation
7. Inhibition of macrophage tumoricidal activity by immune complexes and altered erythrocytes
8. Identification of a T cell hybridoma that produces large quantities of macrophage‐activating factor
9. Enhancement of iron chelation by desferrioxamine entrapped in red blood cell ghosts
10. Colorimetric method for determination of sugars and related substances
11. 111indium‐oxine
12. Iodination of proteins, glycoproteins and peptides using a solid‐phase oxidizing agent, 1,3,4,6‐tetrachloro‐3 alpha, 6 alpha‐diphenyl glycoluril (Iodogen)
13. Biological studies of interferon. I. Suppression of cellular infection with Eastern equine encephalomyelitis virus
14. Protein measurement with the Folin‐phenol reagent
15. Endocytosis of red blood cells or haemoglobin by activated macrophages inhibits their tumoricidal effect
16. Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases
17. Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages
18. Macrophage cytotoxicity: Role for L‐arginine deiminase and imino nitrogen oxidation to nitrate
19. On the carcinogenicity of an iron‐dextran complex
20. Idiopathic refractory sideroblastic anemia
21. Hepatocellular carcinoma in thalassemia major