Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat

Journal of Diabetic Complications

Volumn 2, Issue 1, 1988, Pages 16-18

  McCaleb, Michael L ^a   Sredy, Janet ^a   Millen, Jane ^a   Ackerman, Denis M ^a   Dvornik, Dushan ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; GLUCOSE; NAPHTHALENE DERIVATIVE; SORBITOL; TOLRESTAT;

ANIMAL; ARTICLE; EXPERIMENTAL DIABETES MELLITUS; FEMALE; METABOLISM; PROTEINURIA; RAT; RAT STRAIN;

ALBUMINURIA; ALDEHYDE REDUCTASE; ANIMAL; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GLUCOSE; NAPHTHALENES; RATS; RATS, INBRED STRAINS; SORBITOL; SUGAR ALCOHOL DEHYDROGENASES;

EID: 0023799939     PISSN: 08916632     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-6632(88)90020-7     Document Type: Article

References (21)

1. Microalbuminuria as a predictor of clinical diabetic nephropathy
2. Effects of pancreatic islet transplantation on the increased urinary albumin excretion rates in intact and uninephrectomized rats with diabetes mellitus
3. Near-normoglycemia and late diabetic complications
4. Hyperglycemia, polyol metabolism, and complications of diabetes mellitus
5. Aldose reductase inhibitors
6. N-[[5-(Trifluoromethyl)-6-methoxy-1-napthalenyl]thioxomethyl]-N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor
7. Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment. The mesangial regions
8. Urinary excretion of albumin and total protein in normal and streptozotocin diabetic rats
9. Prevention of neural myoinositol depletion in diabetic rats by aldose reductase inhibition with tolrestat
10. Amelioration of mesangial volume and surface alterations following islet transplantation in diabetic rats
11. Determination of membrane thickness distribution from orthogonal intercepts
12. Renal transplantation in diabetes mellitus in rats
13. Sorbitol, phosphoinositides, and sodium-potassium ATPase in the pathogenesis of diabetic complications
14. Does a common mechanism induce the diverse complications of diabetes?
15. Aldose reductase and sorbitol dehydrogenase distribution in rat kidney
16. Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat
17. Effect of tolrestat in galactosemic dogs
18. Diminished proteinuria in diabetes mellitus by sorbinil, an aldose reductase inhibitor
19. Inhibitors of aldose reductase block diabetes-induced increases in blood flow and GFR and markedly reduce 24 h urinary albumin excretion in the rat
20. Glomerular basement membrane thickness following islet transplantation in the diabetic rat
21. Glycosyl albumin and diabetic microalbuminuria: demonstration of an altered renal handling