Exercise and The Elderly

Exercise and Sport Sciences Reviews

Volumn 16, Issue 1, 1988, Pages 341-379

  Stamford, Bryant A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AGING; BODY CONSTITUTION; BONE; EXERCISE; HEART; HUMAN; JOINT; LUNG; METHODOLOGY; OXYGEN CONSUMPTION; PHYSICAL EDUCATION; PHYSIOLOGY; REVIEW;

AGING; BODY CONSTITUTION; BONE AND BONES; EXERTION; HEART; HUMAN; JOINTS; LUNG; OXYGEN CONSUMPTION; PHYSICAL EDUCATION AND TRAINING;

EID: 0023797976     PISSN: 00916331     EISSN: 15383008     Source Type: Journal    
DOI: 10.1249/00003677-198800160-00014     Document Type: Article

References (277)

1. Abrass, I.B., and P.J. Scarpace. Catalytic unit of adenylate cyclase: Reduced activity in aged-human lymphocytes. J. clin. Endocrinol. Metab. 55:1026–1028, 1982.
2. Adams, G.M., and H.A. deVries. Physiological effects of an exercise training regimen upon women aged 52 to 79. J. Gerontol. 28:50–55, 1973.
3. Adams, W.C., M.M. McHenry, and E.M. Bernauer. Multistage treadmill walking performance and associated cardiorespiratory responses of middle-aged men. Clin. Sci. 42:355–370, 1972.
4. Adrian, M.J. Flexibility in the aging adult. In E.L. Smith and R.C. Serfass (eds.). Exercise and Aging: The Scintific Basis. Hillside. N.J.: Enslow Publishers, 1981, pp. 45–57.
5. Allman, F.L. Conditioning for sports. In A.J. Ryan and F.L. Allman (eds.). Sports Medicine. New York: Academic Press, 1974, pp. 161–179.
6. Altose, M.D., W.C. McCauley, and S.G. Kelson. Effects of hvpercapnia and inspiratory How-resistive loading on respiratory activity in chronic airways obstruction. J. Clin. Invest. 59:500–507, 1977.
7. Aniansson, A., M. Hedberg. G.B. Henning, and G. Grimby. Muscle morphology, enzymatic activity, and muscle strength in elderly men: A follow-up study. Muscle Nerve 9:585–591, 1986.
8. Aniansson, A., G. Grimby, E. Nygaard, and B. Saltm. Muscle fiber composition and fiber area in various age groups. Muscle Nerve 2:271–277, 1980.
9. Aniansson, A., G. Grimby, and A. Rundgren. Isometric and Isokinetic quadriceps muscle strength in 70-vear-old men and women. Scand. J. Rehab. Med. 12:161–168, 1980.
10. Aniansson, A., and E. Gustafsson. Physical training in elderly men with special reference to quadriceps muscle strength and morphology. Clin. Physiol. 1:87–98. 1981.
11. Aniansson, A., G. Grimby, M. Hedberg, and M. Krotkiewski. Muscle morphology, enzyme activity and muscle strength in elderly men and women. Clin. Physiol. 1:73–86, 1981.
12. Aniansson, A., G. Grimby, M. Hedberg, A. Rungren, and L. Spelling. Muscle function in old age. Scand. J. Rehab, Med. 6(suppl.):43–49. 1978.
13. Asmussen, E. Growth in muscular strength and power. In G.L. Rarick (ed.). Physical Activity Human Growth and Development. New York: Academic Press, 1973, p. 60.
14. Asmussen, E., and P. Mathiasen. Some physiological functions in physical education students reinvestigated after twentuy-five years. J Am. Geriatr. Soc. 20:379–387, 1962.
15. Astrand, I. Aerobic work capacity in men and women with special reference to age. Acta Physiol. Scand. 49(suppl. 169): 1–92, 1960.
16. Astrand, I. Exercise electrocardiograms recorded twice with an 8-year interval in a group of 204 women and men 48–63 years old. Acta Med. Scand. 178:27–39, 1965.
17. Astrand, I., P.O. Astrand, and K. Rodahl. Maximal heart rate during work in older men. J. Appl. Physiol. 14:562–566, 1959.
18. Astrand, P.O., and K. Rodahl. Textbook of Work Physiology. New York: McGraw Hill Book Co., 1986.
19. Atkinson, P.J., J.A. Weatherell, and S.M. Weidmann. Changes in density of human femoral cortex with age. J. Bom Joint Surg. 44B:496–502, 1962.
20. Badenhop, D.J., P.A. Cleary, S.F. Schal, E.L. Fox, and R.L. Bartels. Physiological adjustments to higher or lower intensity exercise in elders. Med. Sci. Sports Exerc. 15:496–502, 1983
21. Baily, D.A., R.J. Shephard, R.L. Mirwald, and G.A. McBride. A current view of cardiorespiratory fitness levels of Canadians. Can. Med. Assoc. J. 111:25–30, 1974.
22. Barry, H.C., Exercise prescriptions for the elderly. Am. Fam. Physicians 34:155–162, 1986.
23. Barry, A.J., J.W. Daly, E.D.R. Pruett, J.R. Steinmetz, H.F. Page, N.C. Birkhead, and K. Rodhal. The efiects of physical conditioning on older individuals. I. Work capacity, circulatory-respiratory function, and electrocardiogram. J. Gerontol 21:182–191, 1966.
24. Barry, A.J., J.R. Steinmetz, H.F. Page, and K. Rodahl. The effects of physical conditioning on older individuals. II. Motor performance and cognitive function. J. Gerontol. 21:192–199, 1966.
25. Bauer G. Epidemiology of fracture in aged persons. Clin. Orthop. 27:219–225, 1960.
26. Becklake, M.R., H. Frank, G.R. Dagenais, G.L. Ostiguy, and G.A. Guzman. Influence of age and sex on exercise cardiac output. J. Appl. Physiol. 20:938–947, 1965.
27. Benestad, A.M. Trainability of old men. Acta Med. Scand. 178:321–327, 1965.
28. Bertel, O., F.R. Buhler, W. Klowski, and B.E. Lutold. Decreased beta-adrenoreceptor responsiveness as related to age, blood pressure, and plasma catecholamines in patients with essential hypertension. Hypertension 2:130–138, 1980.
29. Beyer, R.E., and J.E. Fattore. The influence of age and endurance exercise on the myoglobin concentration of skeletal muscle of the rat. J. Gerontol 39:525–530, 1984.
30. Binkhorst, R.A., J. Pool, P. VanLeeuwen, and A. Bouhuys. Maximum oxygen uptake in healthy non-athletic males. Int. Z. Angew. Physiol. Einschl. Arbeitsphysiol. 22:10–18, 1966.
31. Blomqvist, C.G., and B. Saltin. Cardiovascular adaptations to physical training. Ann. Rev. Physiol. 45:169–189, 1983.
32. Bookwalter, K. W. Grip strength norms for males. Res. Q. 21:249–273, 1950.
33. Borkan, G.A., D.E. Hulls, A.F. Gerzof, A.H. Robbins, and C.K. Silbert. Age changes in body composition revealed by computer tomography. J. Gerontol. 38:673–677, 1983.
34. Brewer, V., B.M. Meyer, M.S. Keele, S.J. Upton, and R.D. Hagan. Role of exercise in prevention of involutional bone loss. Med. Sci. Sports Exerc. 15:445–449, 1983.
35. 2. J. Appl. Physiol. 56:1143–1150, 1984.
36. Brown, M. Long-term endurance exercise effects on skeletal muscle in aging rats. Med. Sci. Sports Exerc. 17:245. 1985. (Abstract)
37. Brown, W.F. A method lor estimating the number of motor units in thenar muscles and the change in motor unit fount with ageing. J. Neurol. Nturosurg. Psychiatry 35:845–852, 1972.
38. Brozek, J. Changes of body composition in man during maturity and their nutritional implications. Fed. Proc. 11:784–793, 1952.
39. Bruce, R.A., Exercise, functional aerobic capacity, and aging-another viewpoint. Med. Sci. Sports Exerc, 16:8–13, 1984.
40. Bruce, R.A., L.D. Fisher, M.N. Cooper, and G.O. Gey. Separation of effects of cardiovascular disease and age on ventricular function with maximal exercise. Am. J. Cardiol. 34:757–763, 1974.
41. Buccola, V.A., and W.J. Stone. Effects of jogging and cycling programs on physiological and personality variables m aged men. Res. Q. 46:134–139, 1975.
42. Burke, E.J. Physiological effects of similar training programs in males and females. Res. Q. 48:510–517, 1977.
43. Buskirk, E.R. Health maintenance and longevity: Exercise. In C.E. Finch and E.L. Schneider (eds.). Handbook of the Biology of Aging. 2nd ed. New York: Van Nostrand Reinhold Co., 1985, pp. 894–931.
44. Buskirk, E.R., and J.L., Hodgson. Age and aerobic power: The rate of change in men and women. Fed. Proc. 46:1824–1829. 1987.
45. Campbell, M.J., A.J. McComas, and F. Petito. Physiological changes in ageing muscles. J. Nurol. Nurosurg. Psychiatry 36:174–182, 1973.
46. Cantwell, J.D., and E.O. Watt. Extreme cardiopulmonary fitness in old age. Chest 65:357–359, 1974.
47. Carlsson, K.E., W. Alston, and D.J. Feldman. Electromyographic study of aging in skeletal muscle. Am. J. Phys. Med. 43:141–145, 1964
48. Chalmers, J., and K.C. Ho. Geographical variations in senile osteoporosis. The association with physical activity. J. Bone Joint Surg. 52:667–675, 1970.
49. Chapman, E.A., H.A. deVries, and R. Swezey. Joint stiffness: Effects of exercise on young and old men. J. Gerontol. 27:218–221, 1972.
50. Chesky, J.A., and M. Rockstein. Reduced myocardial actomyosin adenosine tri-phosphatase activity in the aging male Fischer rat. Cardiovasc. Res. 11:242–246, 1977.
51. Chung, E.B. Ageing in human joints. II. Joint capsule. J. Natl. Med. Assoc. 58:254–260, 1966.
52. Comroe, J.H., R E. Forster, A.B. Dubois, W.A. Briscoe, and E. Carlsen. The Lung. Chicago: Year Book Medical Publishers, 1962.
53. Conway, J., R. Wheeler, and R. Sannerstedt. Sympathetic nervous activity during exercise in relation to age. Cardmvasc. Res. 5:577–581, 1971.
54. Cunningham, D.A., E.A. Nancekievill, D.H. Paterson, A.P. Donner, and P.A. Rechnitzer. Ventilation threshold and aging. J. Gerontol. 40:703–707, 1985.
55. Dalen, N., and K.E. Olsson. Bone mineral content and physical activity. Acta Orthop. Scand. 45:170–174, 1974.
56. Davies, C.T.M., J. White, and K. Young. Electrically evoked and voluntary maximal-isometric tension in relation to dynamic muscle performance in elderly male subjects, aged 69 years. Eur. J. Appl. Physiol. 51:37–43, 1983.
57. Davies, C.T.M. The oxygen transporting system in relation to age. Clin. Sci. 42:1–13, 1972.
58. Daykin, H.P. The application ol isometrics in geriatric treatment. Am. Corr Ther. J. 21:203–205, 1967.
59. Dehn, M.M., and R.A. Bruce. Longitudinal variations in maximal oxygen intake with age and activity. J. Appl. Physiol. 33:805–807, 1972.
60. deVries, H.A. Exercise intensity threshold for improvement of cardiovascular-respiratory function in older men. Geriatrics 26:94–101, 1971.
61. deVries, H.A. Physiological etlects ot an exercise training regimen upon men aged 52–88. J. Geraniol 25:325–336, 1970.
62. deVries, H.A., and G.M. Adams. Comparison ot exercise responses in old and young men: II. Ventilatory mechanics. J. Gerontol. 27:349–352, 1972.
63. Dill, D.B., A. Gray bill, A. Hurtado, and A.C. Taguini. Gaseous exchange in the lungs in old age. J. Am. Genatr. Sci. 11:1063–1076, 1963.
64. Dill, D.B., S. Robinson, and J.C. Ross. A longitudinal study ol 16 champion runners. J. Sports Med. 7:4–32, 1967.
65. Dillon, N., S. Chung, J. Kelly, and K. O’Malley. Age and beta-adrenoceptor-mediated tunction. Clin. Pharmorol Ther. 27:769–772, 1980.
66. Drinkwater, B.L., S.M. Horvath, and C.L. Wells. Aerobic power ot females, ages 10 to 68. J. Gerontol 30:385–394, 1975.
67. Drinkwater, B.D., K.L. Nilson, and C.S. Chestnut III. Bone mineral content of amenorrheic and eumenorrheic athletes. N. Engl. J. Med. 311:277–281, 1984.
68. Durnin, J.V.G.A., and J. Womersley. Body fat assessed from total bodv density and its estimation from skinfold thickness: Measurements on 481 men and women aged from 16–72 years. Br. J. Nutr. 32:77–97, 1974.
69. Edelman, N.H., C. Mittman, A.H. Norris, and N.W. Shock. Effects of respiratory pattern on age differences in ventilation uniformity. J. Appl. Physiol. 24:49–53, 1968.
70. Ehsani, A.A. Cardiovascular adaptations to exercise training in the elderly. Fed. Proc. 46:1840–1843, 1987.
71. Eisenberg, E., and G.S. Gordan. Skeletal dynamics in man measured by nonradioaclive strontium. J. Clin. Invest. 40:1809–1825. 1961.
72. Eisenman, P.A., and L.A. Golding. Comparison of effects of training on VO2max in girls and young women. Med. Sci. Sports 2:136–138, 1975.
73. Ekblom, B. Effect of physical training on oxygen transport system in man. Acta Physiol. Scand. 328(suppl.): 1–76, 1969.
74. Ekblom, B., P.O. Astrand, B. Saltin, J. Stenberg, and B. Wallstrom. Effect of training on circulatory response to exercise. J. Appl. Physiol. 24:518–528, 1968.
75. Elveback, L., and J.T. Lie. Combined high incidence of coronary artery disease at autopsy in Olmstead County, Minnesota. Circulation 70:345–349, 1984.
76. Ericsson, P. Total hemoglobin and physical work capacity in elderly people. Acta Med. Scand. 188:15–23, 1970.
77. Esler, M., H. Skews, P. Leonard, G. Jackman, A. Bobik, and P. Korner. Age-dependence of noradrenaline kinetics in normal subjects. Clin. Sci. 60:217–219, 1981.
78. Exton-Smith, A.N. Mineral metabolism. In C.E. Finch and E.L. Schneider (eds.). Handbook of the Biology of Aging, 2nd ed. New York: Van Nostrand, 1985, pp. 511–539.
79. Feldman, R.D., L.E. Limbird, J. Nadeau, D. Robertson, and A.J.J. Wood. Alterations in leucocyte β-receptor affinity with aging. A potential explanation for altered β-adrenergic sensitivity in the elderly. N. Engl. J. Med. 310:815–819, 1984.
80. Fleg, J.L., and E.G. Lakatta. Loss of muscle mass is a major determinant of the age-related decline in maximal aerobic capacity. Circulation 72:Part II, III–464, 1985.
81. Fleg, J.L., S.P. Tzankoff, and E.G. Lakatta. Age-related augmentation of plasma catecholamines during dynamic exercise in healthy males. J. Appl. Physiol. 59:1033–1039, 1985.
82. Fleish, J.H. Age-related decrease in beta-adrenoceptor activity of the cardiovascular system. Trends Pharmacol. Sci. 2:337–339, 1981.
83. Forbes, G.B., and J.C. Rema. Adult lean body mass, declines with age: Some longitudinal observations. Metabolism 653–663, 1970.
84. Friis-Hansen, B. Hydrometry of growth and aging. In J. Brozek (ed.). Human Body Composition. Oxford: Pergamon Press, 1963, pp. 191–209.
85. Frolkis, V.V., O.A. Martynenko, and V.P. Zamostyan. Ageing of the neuromuscular apparatus. Gerontology 22:244–279, 1976.
86. Garn, S.M. Bone loss and aging. In R. Goldman and M. Rockstein (ed.). The Physiology and Pathologs of Aging. New York: Academic Press, 1975, pp. 281–299.
87. Gerstenblith, G., E.G. Lakatta, and MX. Weisfeldt. Age change in myocardial function and exercise response. Prog. Cardiovasc. Dis. 19:1–21, 1976.
88. Gerstenblith, G., D.G. Renlund, and E.G. Lakatta. Cardiovascular responses to exercise in younger and older men. Fed. Proc. 46:1834–1839, 1987.
89. Gerstenblith, G., H.A. Spurgeon, J J.P. Froelich, M L. Weisfeldt, and E.G. Lakatta. Diminished ionotropic responsiveness to ouabain in aged rat myocardium. Circ. Res. 44:517–523, 1979.
90. Getchell, L.H., and J.C. Moore. Physical training: Comparative responses of middle-aged adults. Arch. Pins. Med. Rehab. 56:250–254, 1975.
91. Grahame, R. Diseases of the joints. In J.C. Brocklehurst (ed.). Textbook of Geriatric Medicine and Gerontology. Edinburgh: Churchill-Livingstone, 1973, pp. 367–381.
92. Granath, A., B. Jonsson, and T. Strandell. Circulation in healthy old men studied by right-heart catheterization at rest and during exercise in supine and sitting position. In D. Brunner and E. Jokl (eds.). Mediane and Sport: Physical Activity and Aging. Baltimore: University Park Press. 1970, pp. 48–79.
93. Greenleaf, J.E. Physiological responses to prolonged bed rest and fluid immersion in humans. J. Appl. Physiol. 57:619–633, 1984.
94. Grimby, G., B. Danneskiold-Samsoe, K. Hvid, and B. Saltin. Morphology and enzymatic capacity in arm and leg muscles in 78–81 year old men and women. Acta Physiol. Scand. 115:125–134, 1982.
95. Grimby, G., and B. Saltin. The ageing muscle. Clin. Physiol. 3:209–218, 1983.
96. Grimby, G., and B. Saltin. Physiological analysis of physically well-trained middleaged and old athletes. Acta Med. Scand. 179:513–523, 1968.
97. Grimby, G., J. Bjure, M. Aurell, B. Ekstrom-Jodal, G. Tibblin, and L. Wilhelmsen. Work capacity and physiologic responses to work. Men born in 1913. Am. J. Cardiol. 30:37–42. 1972.
98. Grimby, G., N.J. Nilsson, and B. Saltin. Cardiac output during submaximal and maximal exercise inactive middle-aged athletes. J. Appl. Physiol. 21:1150–1156. 1966.
99. Guarnieri, T., C.R. Filburn, G. Zitnik, G.S. Roth, and E.G. Lakatta. Contractile and biochemical correlates of β-adrenergic stimulation of the aged heart. Am. J. Physiol. 239:H501–H508, 1980.
100. Guimann, E., and V. Hanzlikova. Basic mechanisms of ageing in the neuromuscular system. Mech. Ageing Dev. 1:327–349, 1972.
101. Hagberg, J.M. Effect of training on the decline of VO2max with aging. Fed. Proc. 46:1830–1833, 1987.
102. Hagberg, J.M., W.K. Allen, D.R. Seals, B.F. Hurley, A.A. Ehsani, and JO. Holloszy. A hemodynamic comparison of young and older endurance athletes during exercise. J. Appl. Physiol. 58:2041–2046, 1985.
103. Hakkt, A.H., N.L. DePace, and A.S. Iskandrian. Effect of age on left ventricular function during exercise in patients with coronary artery disease. J. Am. Col. Cardiol. 2:645–651, 1983.
104. Hall, D.A. The Aging of Connective Tissue. London: Academic Press, 1976.
105. Hanson, J.S., B.S. Tabakin, and A.M., Levy. Comparative exercise cardiorespiratory performance of normal men in the third, fourth and fifth decades of life. Clin illation 37:345–360, 1968.
106. Harrison, T.R., K. Dixon, R.O. Russell Jr., P.S. Bidai, and H.N. Coleman. The relation of age to the duration of contraction, ejection, and relaxation of the normal heart. Am. Heart J. 67:189–199, 1964.
107. Hartley, L.H., G. Grimby, A. Kilbom, N.J. Nilsson, I. Astrand, J. Bjure, B. Ekblom. and B. Saltin. Physical training in sedentary middle aged and older men: III. Cardiac output and gas exchange at submaximal and maximal exercise. Scand. J. Clin. Lab. Invest. 24:335–344, 1969.
108. Heath, G.W., J.M. Hagberg, A.A. Ehsani, and J.O. Holloszy. A physiological comparison of young and older endurance athletes. J. Appl. Physiol. 51:634–640, 1981.
109. Higginbotham, M.S., K.G. Morris, R.S. Williams, R.E. Coleman, and F.R. Labb. Physiologic basis for the age-related decline in aerobic work capacity. Am.J. Cardiol. 57:1374–1379, 1986.
110. Hodgson, J.L., and E.R. Buskirk, Physical fitness and age, with emphasis on cardiovascular function in the elderly. J. Am. Geriatr. Soc. 25:385–392, 1977.
111. Hollmann, W. Changes in the capacity for maximal and continuous effort in relation to age. In E. Jokl and E. Simon (eds.). International Research in Sport and Physical Education. Springfield, 111.: C.C. Thomas, 1964, pp. 369–372.
112. Hollman, W. Diminution of cardiopulmonary capacity in the course of life and its prevention by participation in sports. In K. Kato (ed.). Proceedings of the International Congress of Sports Sciences. Tokyo: Japanese Union of Sports Sciences, 1966, pp. 91–93.
113. Horvath, S.M., and J.F. Borgia. Cardiopulmonary gas transport and aging. Am. Rev. Respir. Dis. 129(suppl.):568–571, 1984.
114. Hossack, K.F., and R.A. Bruce. Maximal cardiac function in sedentary normal men and women: Comparison of age-related changes. J. Appl. Physiol. 53:799–804, 1982.
115. Huddleston, A.L., D. Rockwell, D.N. kulund, and R.B. Harrison. Bone mass in lifetime tennis athletes. J.A.M.A. 244:1107–1109, 1980.
116. Irving, J.B., F. Kusumi, and R.A. Bruce. Longitudinal variations in maximal oxygen consumption in healthy men. Clin. Cardiol. 3:134–136, 1980.
117. Jansson, E., C. Sylven, and E., Nordevang. Myoglobin in the quadriceps femoris muscle of competitive cyclists and untrained men. Acta Physiol. Scand. 114:627–629, 1982.
118. Jennekens, F.G.I., B.E. Tomlinson, and J.N. Walton. Histochemical aspects of five limb muscles in old age. An autopsy study. J. Neurol. Sci. 14:259–276, 1971.
119. Johnson, T. Age-related differences in isometric and dynamic strength and endurance. Phys. Ther. 62:985–989, 1982.
120. Jones, H.H., J.D. Priest, W.C. Hayes, C.C. Tichenor, and D.A. Nagel. Humeral hypert rophy in response to exercise. J. Bone Joint Surg. 59:204–208, 1977.
121. Julius, S., A. Amery, L.S. Whitlock, and J. Conway. Influence of age on the hemodynamic response to exercise. Circulation 36:222–230, 1967.
122. Kaijser, L., and C. Sachs. Autonomic cardiovascular responses in old age. Clin. Physiol. 5:347–357, 1985.
123. Kaman, R.L., P.B. Raven, C. Carlisle, and J. Ayres. Age related changes in cardiac enzymes as a result of jogging exercise in man. Med. Sci. Sports 10:46–47, 1978.
124. Kanstrup, I.L., and B. Ekblom. Influence of age and physical activity on central hemodynamics and lung function in active adults. J. Appl. Physiol. 45:709–717, 1978.
125. Karvonen, M.J., E. Kentala, and O. Mustala. The effects of training on heart rate. A longitudinal study. Ann. Med. Exp. Biol. Fenn. 35:307–315, 1957.
126. Kasch, F.W., and J.P. Wallace. Physiological variables during 10 years of endurance exercise. Med. Sci. Sports 8:5–8, 1976.
127. Kasch, F.W., J.P. Wallace, and S.P. Van Camp. Effects of 18 years of endurance exercise on the physical work capacity of older men. J. Cardiac Rehabil. 5:308–312, 1985.
128. Kenney, R.A. Physiology of aging. Clin. Geriatr. Med. 1:37–59, 1985.
129. Kiessling, K.H., L. Pilstrom, A.C. Bylund, B. Saltin, and K. Piehl. Enzyme activities and morphometry in skeletal muscle of middle-aged men after training. Scand. J. Clin. Lab. Invest. 33:63–69, 1974.
130. Kilbnm, A., and I. Astrand. Physical training with submaximal intensities in women. Effect on cardiac output. Scand. J. Clin. Lab. Invest. 28:163–175, 1971.
131. Kilbom, A. Physical training in women. Scand. J. Clin. Lab. Invest. 119(suppl. 28): 1–34, 1971.
132. Krolner, B., E. Tondevold. B. Toft, B. Berthelsen, and S. Ports Nielsen. Bone mass of the axial and the appendicular skeleton in women with Colles’ fracture: Its relation to physical activity. Clin. Physiol. 2:147–157, 1982.
133. Kronenberg, R.S., and C.W. Drage. Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men. J. Clin. Invest. 52:1812–1819, 1973.
134. Kutal, I., J. Parizkova, and J. Dycka. Muscle strength and lean body mass in old men of different physical activity. J. Appl. Physiol. 29:168–171, 1970.
135. LaBella, F.S., and G. Paul. Structure of collagen from human tendons as influenced by age and sex. J. Gerontol. 20:54–59, 1963.
136. Lakatta, E.G. Alterations in the cardiovascular system that occur in advanced age. Fed. Proc. 38:163–167, 1979.
137. Lakatta, E.G. Heart and circulation. In C.E. Finch and E.L. Schneider (eds.). Handbook of the Biology of Aging, 2nd ed. New York: Van Nostrand. 1985, pp. 377–413.
138. Lakatta, E.G. Cardiovascular system. In B. Kentand R.N. Butler (eds.). Human Aging Research: Concepts and Techniques, New York: Raven Press (in press).
139. Lakatta, E.G., and F.C.P. Yin. Myocardial aging: Functional alterations and related cellular mechanisms. Am. J. Physiol. 242:H927–H941, 1982.
140. Lakatta, E.G., G. Gerstenblith, C.S. Angell, N.W. Shock, and M.L. Weisfeldt. Prolonged contraction duration in aged myocardium. J. Clin. Invest. 55:61–68, 1975.
141. Lakatta, E.G. Age-related alterations in the cardiovascular response to adrenergic mediated stress. Fed. Proc. 39:3173–3177, 1980.
142. Lanyon, L.E., and J.A. O’Connor. Adapation of bone artificially loaded at high and low physiological strain rates. J. Physiol. 303:36P. 1980. (Abstract)
143. Larsson, L., B. Sjodin, and J. Karlsson. Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22–65 years. Acta Physiol. Scand. 103:31–39, 1978.
144. Larsson, L., and J. Karlsson. Isometric and dvnamic endurance as a function of age and skeletal muscle characteristics. Acta Physiol. Scand. 104:129–136, 1978.
145. Larsson, L. Histochemical characteristics of human skeletal muscle during ageing. Acta Physml. Scand. 117:469–471, 1983.
146. Larsson, L., G. Grimby, and J. Karlsson. Muscle strength and speed of movement in relation to age and muscle morphology. J. Appl. Physiol. 46:451–456, 1979.
147. Larsson, L. Physical training effects on muscle morphology in sedentary males at different ages. Med. Sci. Sports Exerc. 14:203–206, 1982.
148. Leithead, C.S., and A.R. Lind. Heat Stress and Hecit Disorders. London: Cassell & Company, 1964.
149. Lester, M., L.T. Sheffield, P. Trammell, and T.J. Reeves. The effect of age and athletic training on maximal heart rate during muscular exercise. Am. Heurt J. 76:370–376, 1968.
150. Lexell, J., K. Henriksson-Larsson, B. Wimblad, and M. Sjostrom. Distribution of different fiber types in human skeletal muscle. 3. Effects of aging in m vastus lateralis studies in whole muscle cross-sections. Muscle Nerve 6:588–595, 1983.
151. Lind, A.R., P.W. Hunphrevs, K.J. Collins, K. Foster, and K.F. Sweetland. Influence ot age and daily duration of exposure on responses of men to work in heat. J. Appl. Physiol. 28:50–56, 1970.
152. Londeree, B.R., and M.L. Moeschberger. Effect of age and other factors on maximal heart rate. Res. Q Exer. Sports 53:297–304, 1982.
153. London, G.M., M E. Safar, Y.A. Weiss, and P.L. Milliez. Isoproterenol sensitivity and total body clearance of propranolol in hypertensive patients. J. Clin. Pharmacol. 16:174–183, 1976.
154. MacLennan, W.J., M.R.P. Hall, J.I. Timothy, and M. Robinson. Is weakness in old age due to muscle wasting? Age Ageing 9:188–192, 1980.
155. Mahler, D.A., D.P.E. Cunningham, and G.D. Curfman. Aging and exercise performance. Clin. Genatr. Med. 2:433–452, 1986.
156. Makrides, L., G.J. Heigenhauser, N. McCartney, and N.L. Jones. Maximal short term exercise capacity in healthy subjects aged 15–70 years. Clin. Sci. 69:197–205, 1985.
157. Mann, D.C., B.S. Deneberg, A.K. Gash, P.T. Makler, and A.A. Boue. Effects of age on ventricular performance during graded supine exercise. Am. Heart J. 111: 108–115, 1986.
158. Markrides, S.C. Protein synthesis and degradation during ageing and senescence. Biol. Rev. 58:343–422, 1983.
159. Mazess, R.B. Measurement of skeletal status by noninvasive methods. Calcif. Tissue Int. 28:89–92, 1979.
160. Milne, J.S., and J. Williamson. Respiratory function tests in older people. Clm. Sci. 42:371–381, 1972.
161. Mittman, C., N.H. Edelman, A.H. Norris, and N.W. Shock. Relationship between chest wall and pulmonary compliance and age. J. Appl. Physiol. 20:1211–1216, 1965.
162. Moller, P., and R. Brandt. The effect of physical training in elderly subjects with special reference to energy-rich phosphagens and myoglobin in leg skeletal muscle. Clin. Physiol. 2:307–314, 1982.
163. Montoye, H.J., E.L. Smith, D.F. Fardon, and E.T. Howley. Bone mineral in senior tennis players. Scand. J. Sports Sci. 2:26–32. 1980.
164. Montoye, H.J. Age and oxygen utilization during submaximal treadmill exercise in males. J. Gerontol. 37:396–402, 1982.
165. Montoye, H.J. Physical Activity and Health: An Epidemiologic Study of an Entire Community. Englewood Cliffs, N.J.: Prentice-Hall, 1975.
166. Montoye, H.J., and D.E. Lamphiear. Grip and arm strength in males and females, age 10 to 69. Res. Q. 48:109–120, 1977.
167. Moritam, T., and H.A. deVries. Neural factors versus hypertrophy in the time course of muscle strength gain in young and old men. J. Gerontol. 36:294–297, 1981.
168. Munns, K, Effects of exercise on the range of joint motion in elderly subjects. In E.L. Smith and R.C. Serfass (eds.). Exercise and Aging: The Scientific Basis. Hillside, N.J.: Enslow Publishers, 1981, pp. 167–178.
169. Murray, M.P., G.M. Gardner, L A. Mollinger, and S.B. Sepic. Strength of isometric and isokinetic contractions. Phys. Ther. 60:412–419, 1980.
170. Myhre, L.B., and W. Kessler. Body density and potassium 40 measurements of body composition as related to age. J. Appl. Physiol. 21:1251–1255, 1966.
171. Niinimaa, V., and R.J. Shephard. Training and oxygen conductance in the elderly.I The respiratory system. J. Gerontol. 33:354–361, 1978.
172. Niinimaa, V., and R.J. Shephard. Training and oxygen conductance in the elderly. The cardiovascular system. J. Gerontol. 33:362–367, 1978.
173. Nixon, J.V., H. Hallmark, K. Page, P.B. Raven, and J.H. Mitchell. Ventricular performance in human hearts aged 61–73 years. Am. J. Cardiol. 56:932–937, 1985.
174. Norris, A.B., N.W. Shock, M. Landowne, and J.A. Falzone. Pulmonary function studies: Age ditterences in lung volume and bellows, function. J. Gerontol. 11:379–387, 1956
175. Norris, A. H., N W. Shock, and J.A., Falzone. Relation of lung volumes and maximal breathing capacin to age and socio-economic status. In H.T. Blumenthal (ed.). Medical and Clinical Aspect of Aging. New York: Columbia University Press, 1962. pp. 163–171.
176. Orlander, J., K.H. Kiessling, L. Larsson, J. Larson, and A. Aniansson. Skeletal muscle metabolism and ultrastructure in relation to age in sedentary men. Acta Physiol. Scand. 104:249–261, 1978.
177. Palmer, G.J., M.G. Ziegler, and C.R. Lake. Response of norepinephrine and blood pressure to stress increases with age. J. Gerontol. 33:482–487, 1978.
178. Pariskova, J., E. Liselt, S. Sprynarova, and M. Wachtlova. Body composition, aerobic capacity and density ot muscle capillaries in young and old men. J. Appl. Physiol. 31:323–325, 1971.
179. Patrick, J.M., E.J. Bassey, and P.H. Fentem. The rising ventilaton cost of bicycle exercise in the seventh decade: A longitudinal study of nine healthy men. Clin. Sci. 65:521–526, 1983.
180. Pembermn, J., and E.G Flanagan. Vital capacity and timed vital capacity in normal men over forty. J. Appl. Physiol. 9:291–296, 1956.
181. Peterson, D.D., A.I. Pack, D.A. Silage, and A.P. Fishman. Effects of ageing on respiraton responses to hypoxia and hypcrcapnia. Am. Rev. Respir. Dis. 124:387–391, 1981.
182. Petrofsky, J.S., R L. Burse, and A.R. Lind. Comparison of physiological responses ot women and men to isometric exercise. J. Appl. Physiol. 38:863–868, 1975.
183. Petrofsky, J.S., and A.R. Lind. Aging, isometric strength and endurance and cardiovascular responses to static effort. J. Appl. Physiol. 38:91–95. 1975.
184. Pierson, R.N., D.H.Y. Lin, and R.A. Phillips. Total body potassium in health: Effects of age, sex, height and fat. Am. J. Physiol. 226:206–212, 1974.
185. Plowman, S.A., B.L. Drinkwater. and S.M. Horvath. Age and aerobic power in women: A longitudinal study. J. Gerontol. 34:512–520, 1979.
186. Pollock, M.L., C. Foster, D. Knapp, J.L. Rod, and D.H. Schmidt. Effect of age. training, and competition on aerobic capacity and body composition of masters athletes. J. Appl. Physiol. (In press).
187. Pollock, M.L., G.A. Dawson, H.S. Miller, A. Ward, D. Cooper, W. Headier, A.C. Linnerud, and M.M. Nomeit. Physiologic responses of men 49 to 65 vears of age to endurance training. J. Am. Geriatr. Soc. 24:97–104, 1976.
188. Pollock, M.L., H.S. Miller, and J. Wilmore. Physiological characteristics of champion American track athletes 40 to 75 years of age. J. Gerontol. 29:643–650, 1974.
189. Port, S., F.R. Cobb, R.L. Coleman, and R.H. Jones. Effect of age on the response ol the left ventricular ejection fraction to exercise. N. Engl. J. Med. 303:1133–1137.1980.
190. Profant, G R., R.G. Earh, K.L. Nilscm, F. Kusumi, V. Hofer, and R.A. Bruce. Responses to maximal exercise in healthy middle-aged women. J. Appl. Physiol. 33:595–599, 1972.
191. Purcell, Y., and B. Brozovic. Red cell 2,3-diphosphoglycerate concentration in man decreases with age. Nature 251:511–512, 1974.
192. Raven, P.B., and J. Mitchell. The effect of aging on the cardiovascular response to dynamic and static exercise. In M.L. Weisfeidt (ed.). The Aging Heart. New York: Raven Press. 1980, pp. 269–296.
193. Reinhard, U., P.H. Mueller, and R.M. Schmuclling. Determination of anaerobic 13 threshold by the ventilation equivalent in normal individuals. Respiration, 38:36–42, 1979.
194. Rizzato, G., and L. Marazzini. Thoracoabdominal mechanics in elderly men. J. Appl. Physiol. 28:457–460, 1970.
195. Robinson, S. Circulatory adjustments of men in hot environments. In J.D. Hardy (ed.). Temperature: Its Measuremenit and Control in Snence and Industry, Vol. 3, Part 3, New York: Reinhold Book Corporation, 1963, p. 287.
196. Robinson, S., D.B. Dill, J.C. Ross, R.D. Robinson, J.A. Wagner, and S.P. Tzankoff. Training and physiological aging in man. Fed. Proc. 32:1628–1634, 1973.
197. Robinson, S. Experimental studies of physical Illness in relation to age. Arbeitsphysiologie 20:251–323, 1938.
198. Robinson, S., D.B. Dill, S.P. Tzankolt, J.A. Wagner, and R.D. Robinson. Longitudinal studies of aging in 37 men. J. Appl. Physiol. 38:263–267, 1975.
199. Rockstein, M., J.A. Ghesky, and T. Lopez. Effects of exercise on the biochemical aging of mammalian myocardium. I. Actomyosin ATPase. J. Gerontol. 36:294–297, 1981.
200. Rodahl, K., N.C. Birkhead, J. Blizzard, B. Issekutz, and E.D.R. Pruett. Physiological changes during prolonged bed rest. In G. Blix (ed.). Nutrition and Physical Activity. Stockholm: Almqvist and Wiksell, 1967, p. 107.
201. Rodeheffer, R.J., G. Gerstenblith, L.C. Becker, J.L. Fleg, M I. Weisfeldt, and E.G. Lakatta. Exercise cardiac output is maintained with advancing age in healthy human subjects: Cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation 69:203–213, 1984.
202. Rodriguez, M.J., J.J. DePalma, and H.P. Daykin. Isometric exercise in general practice. J. Assoc. Phys. Ment. Rehab. 19:197–200, 1965.
203. Roskamm, H. Optimum patterns of exercise for healthy adults. In Proceedings of International Symposium on Physical Activity and Health. Can. Med. Assoc. J. 96:895–899, 1967.
204. Rubin, C.P., P.J. Scott, K. McLean, and J.C. Reid. Noradrenaline release and clearance in relation to age and blood pressure in man. Fur. J. Clin. Invest. 12:121–125, 1982.
205. 2 and inspiratory resistive loads. J. Gerontol. 37:306–310, 1982.
206. Saltin, B., L.H. Hartley, A. Kilborm, and I. Astrand. Physical training in sedentary middle-aged and older men. II. Oxygen uptake, heart rate, and blood lactate concentration at submaximal and maximal exercise. Scand. J. Clin. Lab. Invest. 24:323–334, 1969.
207. Sawin, C.S., J.A. Rummel, and E.L. Michel. Instrumental personal exercise during long duration space flights. Aviat. Space Environ. Med. 46:394–400, 1975.
208. Schocken, D.D., J.A. Blumenthal, S. Porit, P. Hindle, and R.E. Coleman. Physical conditioning and left ventricular performance in the elderly. Am. J. Cardiol. 52:359–364, 1983.
209. Schmidt, C.D., M.L. Dickman, R.M. Gardner, and F.K. Brough. Spirometrie standards for healthy elderly men and women. Am. Rev. Respir. Dis. 108:933–939, 1973.
210. Seals, D.R., J.M. Hagberg, B.F. Hurley, A.A. Ehsani, and J.O. Holloszy. Endurance training in older men and women. I. Cardiovascular responses to exercise. J. Appl. Physiol. 57:1024–1029. 1984.
211. Seals, D.R., B.F. Hurley, J. Schultz, and J.H. Hagberg. Endurance training in older men and women. II. Blood lactate response to submaximal exercise. J. Appl. Physiol. 57:1030–1033, 1984.
212. Sheffield, L.T., J.A. Maloof, J.A. Sawyer, and D. Roitman. Maximal heart rate and treadmill performance of healthy women in relation to age. Circulation 57:79–84, 1978.
213. Shephard R.J., Physical Acitivity and Aging. Chicago: Year Book Medical Publishers. 1978.
214. Shephard K.J. World standards of cardiorespiratory performance. Arch. Environ. Health 13:664–670, 1966.
215. Shephard R.J. Endurance fitness. 2nd ed. Toronto: University of Toronto Press, 1977.
216. Shephard K.J. and R.H. Sidney. Exercise and aging. In R.S. Hutton (ed.). Exercise and Sport Sciences, Reviews. Vol. 6. Philadelphia: Franklin Institute Press. 1978, pp. 1–57.
217. Shock, N.W. Aging of homeostatic mechanisms. In A. Lansing (ed.). Problems of Ageing. Baltimore: Williams & Wilkins Co., 1952, pp. 415–446.
218. Shock N.W. Physiological aspects of aging in man. Ann. Rev. Physiol. 23:97–122, 1961.
219. Shock N.W., D.M. Watkin M.J. Yiengst, A.H. Norris, G.W. Gafney, R.I. Gregerman, and J.A. Falzone. Age differences in the water content of the body as related to basal oxygen consumption in males. J. Gerontol. 18:1–8, 1963.
220. Sidney, K.H., and R.J. Shephard. Attitudes towards health and physical training in the elderly. Effects of a physical training program. Med. Sci. Sports 8:246–252, 1976.
221. Sidney, K.H., and R.J. Shephard. Activity patterns of elderly men and women. J. Gerontol. 32:25–32, 1977.
222. Sidney K.H., and R J. Shephard. Training and electrocardiographic abnormalities in the elderly. Br. Heart J. 39:1114–1120, 1977.
223. Sidney, K.H., and R.J. Shephard. Maximum and submaximum exercise tests in men and women in the seventh, eighth and ninth decades of life. J. Appl. Physiol. 43:280–287, 1977.
224. Sidney, K.H., and R.J. Shephard. Frequency and intensity of exercise training for elderly subjects. Med. Sci. Sport 10:125–131, 1978.
225. Sidney, K.H., R.J. Shephard, and J.E. Harrison. Endurance training and body composition of the elderly. Am. J. Clin. Nutr. 30:326–333, 1977.
226. Simonson E. Physical fitness and work capacity of older men. Geriatrics 2:110–119, 1947.
227. Sjosirom, M., K.A. Angquist. and O. Rais. Intermittent claudication and muscle fiber fine structure: Correlation between clinical and morphological data, Ultrastruct. Pathol. 1:309–326, 1980.
228. Sjostrom, M., P. Neglen J. Friden and B. Eklof. Human skeletal muscle metabolism and morphology after temporary incomplete ischaemia. Eur.J. Clin, invest. 12:69–79,1982.
229. Skinner, J.S. Age and performance. In J. Kuel (ed.). Limiting Faetón of Physical Performance. Stuttgart: Thiene. 1973, pp. 271–282.
230. Skinner, J.S., CM. Tipton, and A.C. Vailas. Exercise, physical trainingand the ageing process, In A. Viidik (ed.). Lectures on Gerontology, Vol. 1., Part B. London: Academic Press. 1982, pp. 407–439.
231. Skrobak-Kaczynski, J., and K.L. Andersen. The effect of a high level of habitual physical activity in the regulation of fatness during aging. Int. Arch. Occup. Environ Health 36:41–46. 1975.
232. Smith, E.L., W. Reddan, and P.E. Smith. Physical activity and calcium modalities for bone mineral increase in aged women. Med. Sci. Spoils Exerc. 13:60–64, 1981.
233. Smith, E.L., P.E. Smith, C.J. Ensign, and M.M. Shea. Bone involution decrease in exercising middle-aged women. Calcif. Tissue Int. 36(suppl. 1):S129–S138, 1084
234. Smith, E.E., and U. Reddan. Physical activity—a modality for bone accretion in the aged. Am. J. Roentgenol. 126:1297, 1977. (Abstract)
235. Smith, E.L. Exercise tor prevention ot osteoporosis: A review. Physician Sportsmed. 10:72–83, 1982.
236. Smith, E.E., and C. Gilligati. Phcsical activity tor the older adult. Physician Sportsmed. 11:91–101, 1983.
237. Spira, E. Orthopedic observations with physically ac tive elderly subjects. In D. Brunner and E. jokl (eds.). Physical Activity and Aging. Baltimore: University Park Press. 1970. pp. 307–308.
238. Spurgeon, H.A., M.F. Steinbach and E.G. Lakatta. Chronic exercise prevents characteristic age-ielated changes in rat cardiac contraction. Am. J. Physiol. 244:H513–H5I8, 1983.
239. Stamford, B.A. Physiological effects of training upon institutionalized geriatric men. J. Gerontol. 27:451–455, 1972.
240. Stamford, B.A. Effects of chronic institutionalization on the physical working capacity and trainabilin of geriatric men. J. Gerontol. 28:441–446, 1973.
241. Strandell, T. Circulatory studies on healthy old men. Ada Med. Scand. 414(suppl.): 1–43, 1964.
242. Strandell, T, Heart rate, arterial lactate concentration and oxygen uptake during exercise in old men compared to voung men. Acta Physiol. Scand. 60:197–201, 1964.
243. Strandell T. Cardiac output in old age. In F.T. Carid. J.L.C. Doll, and R.D. Kennedy (eds.). Cardiology in Old Age. New York: Plenum Press, 1967, p. 160.
244. Suominen, H., E. Heikkinen, P. Vainio and T. Eahtinen. Mineral density ol calcaneus in men at diff erent ages: A population study with special reference to life-style factors. Age Ageing 13:273–281, 1984.
245. Suominen H., E. Heikkinen H. Liesen, D. Michel, and W. Hollmann. Effects of 8 weeks’ endurance training on skeletal muscle metabolism in 56–70 year old sedentary men. Eur. J. Appl. Physiol. 37:173–180, 1977.
246. Suominen, H., E. Heikkinen, and I. Parkatti. Effects of eight weeks’ physical training on muscle and connective tissue of die m. vasius lateralis in 69 year old men and women. J, Gerontol. 32:33–37, 1977.
247. Syrovy, I., and E. Gutmann. Changes in speed of contraction and ATPase activity in striated muscle during old age. Exp. Gerontol. 5:31–35, 1970.
248. Tejada, C., J.P. Strong, M.R. Montenegro, C. Restrepo, and L.A. Solberg. Distribution of coronary and aortic atherosclerosis by geographic location, race, and sex. Lab. Invest. 18:509–526, 1968.
249. Templeton G.H., M.R. Platt J.T. Willerson and M.L. Weisleldt Influence of aging on left ventricular hemodvnamics and stiffness in beagles. Circ. Res. 44:189–194, 1979.
250. Thomas S.G., D.A. Cunningham, P.A. Rechnitzer, A.P. Donner, and J.H. Howard. Determinants of the training response in elderly men. Med. Sci. Sports Exerc. 17:667–672, 1985.
251. Thorstensson, A., G. Grimby, and J. Karlsson. Force-velocity relations and fiber composition in human knee extensor muscles. J. Appl. Physiol. 40:12–16, 1976.
252. Timiras, P.S. Developmental Physiology and Aging. New York: Macmillan Co., 1972.
253. Tlusty, L, Physical fitness in old age. I. Aerobic capacity and the other parameters of physical fitness followed by means of graded exercise in ergometric examination of elderly individuals. Respiration 26:161–181, 1969.
254. Tomonaga, M. Histochemical and ultrastructural changes in senile human skeletal muscle, J. Am. Geriatr. Soc. 25:125–131, 1977.
255. Turner, J.M., J. Mead, and M E. Wohl. Elasticity of human lungs in relation to age. J. Appl. Physiol. 25:664–671, 1968.
256. Tweeddale, P.M., R.J.F. Leggett, and D.C. Finley. Effect of age on oxygen-binding in normal human subjects. Clin. Sci. Mol. Med. 51:185–188, 1976.
257. Tzankoff S.P., and A.H. Norris. Effect of muscle mass decrease on age-related BMR changes. J. Appl. Physiol. 43:1001–1006, 1977.
258. Tankoff, S.P. S. Robinson, F.S. Pyke, and C.A. Brawn. Physiological adjustments to work in older men as affected by physical training. J. Appl. Physiol. 33:346–350, 1972.
259. Van Tosh, A., E.G. Lakatta, J.L. Fleg, J. Weiss, C. Kaliman M. Weisfeldt, and G. Gerstenbith. Ventricular dimension changes during submaximal exercise: Effect of aging in normal man. Circulation 62(suppl. 3): 129, 1980. (Abstract)
260. Vestal, R.E., A.J. Wood, and D.G. Shand. Reduced β-adrenoceptor sensitivity in the elderly. Clin. Pharmacol. Ther. 26:181–186, 1979.
261. Viljanen, A. (ed). Reference values for spirometric, pulmonary diffusing capacity and body plethysmographic studies. Scand. J. Clin. Lab. Invest. 42(suppl. 159):5–50, 1982.
262. Vogel, J.M., and M.W. Whittle. Bone mineral changes: The second manned Skylab mission. Aviat. Space Environ. Med. 47:396–400, 1976.
263. Voigt A.E., R.A. Bruce F. Kusumi, G. Pettet, K. Neilson, B. Whitkanack, and J. Tapia. Longitudinal variations in maximal exercise performance of healthy sedentary middle aged women. Sports Med. 15:323–327, 1975.
264. von Dobelin, W., I. Astrand, and A. Bergstrom. Analysis of age and other factors related to maximal oxygen uptake. J. Appl. Physiol. 22:934–938, 1967.
265. Weisfeldt, M.L. Aging of the cardiovascular system. N. Engl. J. Med. 303:1172–1173, 1980.
266. Wessel J.A., D.A. Small W.D. Van Huss D.I. Anderson and D.C. Cederquist. Age and physiological response to exercise in women 20–69 years of age. J. Gerontol. 23:269–279, 1968.
267. Wessel, J.A., A. Ufer, W.D. Van Huss, and D. Cederquist. Age trends of various components of body composition and functional characteristics in women aged 20–69 years. Ann. N.Y. Acad. Sci. 110:608–622, 1963.
268. White, N.K., J.E. Edwards, and T.J. Dry. The relationship of the degree of coronary atherosclerosis with age, in men. Circulation 1:645–654, 1950.
269. Wilmore, J.H., J. Royce, R.N. Girandola. F.I. Katch, and V.I. Katch. Physiological alterations resulting from a ten week program of jogging. Med. Sci. Sports 2:7–14, 1970.
270. Wollein, W., N. Bachl and L. Prokop. Endurance capacity of trained older aged athletes. Eur. Heart J. 5(suppl):21–25, 1984.
271. Wright, V., and R.J. Johns. Physical factors concerned with the stiffness of normal and diseased joints. Bull. Johns Hopkins Hosp. 106:215–231, 1960.
272. Yerg, J.E., D.R. Seals, J.M. Hagberg and J.O. Holloszy. Effect of endurance exercise training on ventilatory function in older individuals. J. Appl. Physiol. 58:791–794, 1985.
273. Yin, F.C.P., H.A. Spurgeon M.L. Greene, E.G. Lakatta, and M.L. Weisfeldt. Age-associated decrease in heart rate response to isoproterenol in dogs. Mech Ageing Dev 10:17–25, 1979.
274. Young, A., M. Stokes, and M. Crowe. The size and strength of the quadriceps muscles of old and young women. Eur. J. Clin. Invest. 14:282–287, 1984.
275. Young, A., M. Stokes, and M. Crowe, The size and strength of the quadriceps muscles of old and young men. Clin. Physiol. 5:145–154, 1985.
276. Young, J.B., J.W. Rowe, J.A. Pallotta, D. Sparrow, and L. Landsberg. Enhanced plasma norepinephrine response to upright posture and oral glucose administration in elderly human subjects. Metabolism 29:532–539, 1980.
277. Ziegler, M.G., C.R. Lake, and J.J. Kopin. Plasma Noradrenaline increases with age. Nature 261:333–335, 1976.