The enantiomers of the teratogenic thalidomide analogue EM 12 - 1. Chiral inversion and plasma pharmacokinetics in the marmoset monkey

Archives of Toxicology

Volumn 62, Issue 2-3, 1988, Pages 200-204

  Schmahl, Hans Josef ^a   Nau, Heinz ^a   Neubert, Diether ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

2 (2,6 Dioxopiperidine 3 yl) phthalimidine; 3 (1,3 Dihydro 1 oxo 2H isoindol 2 yl) 2,6 dioxo piperidine; Callithrix jacchus; Chiral inversion; EM 12; Enantiomers; Marmosets; Pharmacokinetics; Thalidomide derivative

Indexed keywords

2 (2,6 DIOXO 3 PIPERIDINYL)PHTHALIMIDINE; 2 (2,6 DIOXOPIPERIDIN 3 YL)PHTHALIMIDINE; TERATOGENIC AGENT; THALIDOMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ENANTIOMER; INTRAPERITONEAL DRUG ADMINISTRATION; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RACEMIZATION; STEREOSPECIFICITY;

ANIMAL; CALLITRICHINAE; STEREOISOMERISM; SUPPORT, NON-U.S. GOV'T; THALIDOMIDE;

EID: 0023794852     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/BF00570140     Document Type: Article

References (11)

1. Chromatographische Racemattrennung von Thalidomid und teratogene Wirkung der Enantiomere
2. Pharmacodynamic and pharmacokinetic differences between drug enantiomers in humans: an overview
3. Toxicity and teratogenicity of optical isomers of thalidomide
4. Comparative teratological investigation of compounds structurally and pharmacologically related to thalidomide
5. Identification of urinary metabolites of EM 12 [N-(2′,6′-dioxopiperiden-3′-yl)-phthalimidine], a teratogenic analog of thalidomide in rats and rabbits
6. Das l-Isomere als teratogenes Prinzip der N-Phthalyl-DL-glutaminsäure
7. Relationships between stereostructure and pharmacological activities
8. Präparative and analytische Trennung der Enantiomeren des teratogenen Racemats EM 12 (2-(2,6-Dioxopiperidin-3-yl)-phthalimidin) mittels Niederdruck-Säulenchromatographie (LC) und HPLC
9. Pharmacokinetics of the teratogenic and non-teratogenic thalidomide analogue EM 12 and supidimide in the rat and marmoset monkey
10. The teratogenic activity of a thalidomide analogue, EM 12, in rabbits, rats, and in monkeys
11. Non-confirmation of thalidomide induced teratogenesis in rats and mice