3,7-Dimethyl-1-propargylxanthine: A potent and selective in vivo antagonist of adenosine analogs

Life Sciences

Volumn 43, Issue 21, 1988, Pages 1671-1684

  Seale, Thomas W ^a   Abla, Kathleen A ^a   Shamim, Mah T ^b   Carney, John M ^c   Daly, John W ^b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; 8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); CAFFEINE; CYCLOHEXYLADENOSINE; THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; DRUG EFFICACY; HYPOTHERMIA; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIDE EFFECT;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMAL; BODY TEMPERATURE; CAFFEINE; MALE; MICE; MICE, INBRED DBA; MOTOR ACTIVITY; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T; THEOBROMINE; THEOPHYLLINE;

EID: 0023794288     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(88)90478-X     Document Type: Article

References (29)

1. Subclasses of external adenosine receptors.
2. Adenosine receptor binding: structure-activity analysis generates extremely potent xanthine antagonists.
3. Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines