Counterregulatory hormonal responses to hypoglycaemia in Type 1 (insulin-dependent) diabetes: evidence for diminished hypothalamic-pituitary hormonal secretion

Diabetologia

Volumn 31, Issue 7, 1988, Pages 421-429

  Frier, B M ^a   Fisher, B M ^a   Gray, C E ^b   Beastall, G H ^b  

^a GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

^b GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

adrenaline; beta endorphin; diabetes mellitus; Hypoglycaemia; hypothalamus; insulin; pituitary hormones

Indexed keywords

ADRENALIN; BETA ENDORPHIN; INSULIN;

ADULT; CLINICAL ARTICLE; DIABETES MELLITUS; FEMALE; HUMAN; HYPOGLYCEMIA; HYPOTHALAMUS; MALE; PRIORITY JOURNAL;

ADULT; AGED; BETA-ENDORPHIN; BLOOD GLUCOSE; COMPARATIVE STUDY; CORTICOTROPIN; DIABETES MELLITUS, INSULIN-DEPENDENT; EPINEPHRINE; FEMALE; GLUCAGON; GROWTH HORMONE; HORMONES; HUMAN; HYPOGLYCEMIA; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN; MALE; MIDDLE AGE; PROLACTIN; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T;

EID: 0023789224     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF00271586     Document Type: Article

References (38)

1. The hypothalamus and blood glucose regulation
2. Substantial rise of plasma β-endorphin levels after insulin-induced hypoglycemia in human subjects
3. β-endorphin and adrenocorticotropin are secreted concomitantly by the pituitary gland
4. Hypoglycaemia and diabetes
5. Glucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus
6. Abnormal glucose counterregulation in insulin-dependent diabetes mellitus. Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion
7. C-peptide response to glucagon. A test for the residual β-cell function in diabetes mellitus
8. Testing for autonomic neuropathy
9. Impaired response of pancreatic polypeptide to hypoglycaemia: an early sign of autonomic neuropathy in diabetes
10. Detection of microalbuminuria in diabetic patients using a simple latex agglutination test
11. A micro enzyme-linked immunosorbent assay for insulin antibodies in serum
12. Circulating dopamine: its effect on the plasma concentration of catecholamines, renin, angiotensin, aldosterone and vasopressin in the conscious dog
13. Rapid radioimmunoassay for corticotropin in unextracted human plasma
14. Laboratory assessment of prolactin status
15. Triglyceride metabolism in acute starvation: the role of secretion and glucagon
16. Studies on the conditions of activity in endocrine glands. XIII. A sympathetic and adrenal mechanism for mobilizing sugar in hypoglycaemia
17. Identification of type 1 diabetic patients at increased risk for hypoglycemia during intensive therapy
18. Subnormal pancreatic polypeptide and epinephrine responses to insulin-induced hypoglycemia identify patients with insulin-dependent diabetes mellitus predisposed to develop overt autonomic neuropathy
19. Abnormal glucose counterregulation after subcutaneous insulin in insulin-dependent diabetes
20. The importance of plasma free insulin and counterregulatory hormones for the recovery of blood glucose following hypoglycaemia in Type 1 diabetics
21. Glucose counterregulation during prolonged hypoglycemia in normal humans
22. Defective epinephrine and growth hormone responses in Type I diabetes are stimulus specific
23. Studies of inadvertent hypoglycemic episodes during continuous blood glucose analysis
24. Relation of counterregulatory responses to hypoglycemia in Type I diabetes
25. Plasma cortisol response to insulin and circadian rhythm in diabetic subjects
26. Hormonal responses to insulin infusion in diabetes mellitus
27. Severe insulin-induced hypoglycemia associated with deficiencies in the release of counterregulatory hormones
28. Impaired ACTH and glucagon response to hypoglycaemia in an insulin-treated diabetic
29. Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms
30. Endogenous opioids: biology and function
31. Diabetes induced by streptozocin results in a decrease in immunoreactive beta-endorphin levels in the pituitary and hypothalamus of female rats
32. Does central nervous system adaptation to antecedent glycemia occur in patients with insulin-dependent diabetes mellitus
33. Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type 1 diabetes
34. Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus
35. Altered recognition of hypoglycaemic symptoms in Type 1 diabetes during intensified control with continuous subcutaneous insulin infusion
36. Blood-brain glucose transfer. Regression in chronic hyperglycaemia