In vivo inhibition of foam cell development by probucol in Watanabe rabbits

The American Journal of Cardiology

Volumn 62, Issue 3, 1988, Pages

  Steinberg, Daniel ^a   Parthasarathy, Sampath ^a   Carew, Thomas E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN; MEVINOLIN; PROBUCOL;

AORTA ATHEROSCLEROSIS; FATTY STREAK; FOAM CELL; HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SHORT SURVEY;

ANIMAL; ARTERIOSCLEROSIS; COMPARATIVE STUDY; DEPRESSION, CHEMICAL; DRUG EVALUATION, PRECLINICAL; FOAM CELLS; HYPERLIPIDEMIA; LIPOPROTEINS, LDL; LOVASTATIN; MACROPHAGES; OXIDATION-REDUCTION; PHENOLS; PROBUCOL; RABBITS;

EID: 0023789171     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(88)80044-4     Document Type: Article

References (14)

1. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis
2. Lysolecithin as a chemoattractant during the oxidative modification of LDL
3. Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein
4. LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture
5. Injury to human endothelial cells in culture induced by low density lipoprotein
6. Probucol inhibits oxidative modification of low density lipoprotein
7. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis
8. A radioiodinated, intracellularly trapped ligand for determining the sites of plasma protein degradation in vivo
9. Measurement in vivo of irreversible degradation of low density lipoprotein in the rabbit aorta. Predominance of intimal degradation
10. Mechanisms involved in the uptake and degradation of low density lipoprotein by the artery wall in vivo
11. A novel mechanism by which probucol lowers low density lipoprotein levels demonstrated in the LDL receptor-deficient rabbit
12. Effects of probucol on xanthomata regression in familial hypercholesterolemia
13. Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein
14. Fatty streak initiation in Watanabe heritable hyperlipemic and comparably hypercholesterolemic fat-fed rabbits