21-aminosteroid lipid peroxidation inhibitor u74006f protects against cerebral ischemia in gerbils

Stroke

Volumn 19, Issue 8, 1988, Pages 997-1002

  Hall, Edward D ^a   Pazara, Kay E ^a   Mark Braughler, J ^a  

^a PFIZER INC   (United States)

Author keywords

Cerebral ischemia; Gerbils; Hippocampus; Lipid peroxidation

Indexed keywords

TIRILAZAD;

ANIMAL EXPERIMENT; BRAIN ISCHEMIA; HIPPOCAMPUS; HISTOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; MAMMAL; MONKEY; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; BRAIN ISCHEMIA; GERBILLINAE; LIPID PEROXIDES; MALE; PREGNATRIENES;

EID: 0023785218     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/01.STR.19.8.997     Document Type: Article

References (23)

1. Flamm ES, Demopoulos HB, Seligman ML, Poser RG, Ransohoff J: Free radicals in cerebral ischemia. Stroke 1978; 9:445-447
2. Demopoulos HB, Flamm ES, Pietronigro DD, Seligman ML: The free radical pathology and the microcirculation in the major central nervous system disorders. Ada Physiol ScandSuppl 1980;494:91-119
3. Chance B, Nishiki K, Oshino N: Glutathione release, as indicator of hyperoxic stress, in Jobsis FF (ed): Oxygen and Physiological Function. Dallas, Professional Information Library, 1977, pp 388-402
4. Yoshida S, Abe K, Busto R, Watson BD, Kogure K, Ginsberg MD: Influence of transient ischemia on lipid soluble antioxidants, free fatty acids and energy metabolites in rat brain. Brain Res 1982;245:307-316
5. Watson BD, Busto R, Goldberg WJ, Santiso M, Yoshida S, Ginsberg MD: Lipid peroxidation in vivo induced by reversible global ischemia in rat brain. J Neurochem 1984;42:268-274
6. Yoshida S, Busto R, Watson BD, Santiso M, Ginsberg MD: Postischemic cerebral lipid peroxidation in vitro: Modification by dietary vitamin E. J Neurochem 1985;44:1593-1601
7. Kirsch JR, Phelan AM, Lange DG, Traystman RJ: Reperfusion induced free radical formation following global ischemia (abstract). Pediatr Res 1987;21:202A
8. Snelling LK, Ackerman AD, Dean JM, North MC, Traystman RJ: The effects of superoxide dismutase on neurological recovery (cerebral blood flow and evoked potentials) following global cerebral ischemia (abstract). Anesthesiology 1987;67:A153
9. Davis RJ, Bulkley GB, Traystman RJ: Role of oxygen free radicals in focal brain ischemia (abstract). Fed Proc 1987; 46:799
10. Yamamoto M, Shima T, Uozumi T, Sogabe T, Yamada K, Kawasaki T: A possible role of lipid peroxidation in cellular damage caused by cerebral ischemia and the protective effect of α-tocopherol administration. Stroke 1983;14:977-982
11. FujimotoS, Mizoi K, YoshimotoT, Suzuki J: The protective effect of vitamin E on cerebral ischemia. Surg Neurol 1984; 22:449-454
12. Braughler JM, Chase RL, NeffGL, Yonkers PA, Day JS, Hall ED, Sethy VH, Lahti RA: A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates ACTH secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells. J Pharmacol Exp Ther 1988;244:423-427
13. Braughler JM, Pregenzer JF, Chase RL, Jacobsen EJ, McCall JM: Novel 21-amino-substituted steroids as potent inhibitors of iron-dependent lipid peroxidation. J Biol Chem 1987;262: 10438-10440
14. Braughler JM, Lainer MJ: The effects of large doses of methylprednisolone on neurologic recovery and survival in the Mongolian gerbil following three hours of unilateral carotid occlusion. CNS Trauma 1986,3:153-162
15. Levine S, Sohn D: Cerebral ischemia in infant and adult gerbils. Relation to incomplete circle of Willis. Arch Pathol 1969;87:315-317
16. Kahn K: The natural course of experimental cerebral infarction in the gerbil. Neurology 1972;22:510-515
17. Gaudet RJ, Levine L: Transient cerebral ischemia and brain prostaglandins. Biochem Biophys Res Commun 1979;86: 893-901
18. Kuehl FA, Humes J, Torchiana ML: Oxygen-centered radicals in inflammatory processes. Adv Inflamm Res 1979;1: 419-430
19. 2 dependent release of fatty acids from peroxidized membranes. J Free Rad Biol Med 1985;1:263-271
20. Hall ED, Yonkers PA: Attenuation of postischemic cerebral hypoperfusion by the 21-amino steroid U74006F. Stroke 1988; 19:340-344
21. Hall ED: Mechanisms of progressive CNS hypoperfusion following trauma, subarachnoid hemorrhage and ischemia, in Tsuchiya M, Asana M, Mishima Y, Oda M (eds): Microcirculation: An Update. Amsterdam, Excerpta Medica, 1987, vol l, pp553-556
22. Black KL, HoffJT, Radin NS, Deshmukh GD: Eicosapentaenoic acid: Effect on brain prostaglandins, cerebral blood flow and edema in ischemic gerbils. Stroke 1984;15:65-69
23. Braughler JM: Lipid peroxidation-induced inhibition of γ-aminobutyric acid uptake in rat brain synaptosomes: Protection by glucocorticoids. J Neurochem 1985;44:1282-1288