Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures

Journal of Experimental Medicine

Volumn 168, Issue 3, 1988, Pages 853-862

  Lebman, Deborah A ^a   Coffman, Robert L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 4;

ANIMAL CELL; B LYMPHOCYTE; CELL CLONE; CELL CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMAL; B-LYMPHOCYTES; CLONE CELLS; GENE EXPRESSION REGULATION; GENES, SWITCH; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; IMMUNOGLOBULINS, SURFACE; IMMUNOLOGIC TECHNIQUES; IN VITRO; INTERLEUKIN-4; INTERLEUKINS; LYMPHOCYTE COOPERATION; MICE; T-LYMPHOCYTES;

EID: 0023785192     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.168.3.853     Document Type: Article

References (30)

1. Coffman, R. L., J. Ohara, M. W. Bond, J. Carty, A. Zlotnik, and W. E. Paul. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol. 136: 4538.
2. Lee, E, T. Yokota, T. Ostuka, P Meyerson, D. Villaret, R. Coffman, T Mosmann, D. Rennick, N. Roehm, C. Smith, A. Zlotnik, and K. Arai. 1986. Isolation and characterization of a mouse interleukin cDNA clone that expresses B cell stimulatory factor-1 activities and T cell and mast cell stimulating activities. Proc. Mad. Acad. Sci. USA. 83: 2061.
3. Vitetta, E. S., J. Ohara, C. Myers, J. Layton, P. H. Krammer, and W. E. Paul. 1985. Serological, biochemical, and functional identity of B cell stimulatory factor-1 and B cell differentiation factor for IgG1. J Exp. Med. 162: 1726.
4. Coffman, R. L., F. Lee, T Yokota, K. Arai, and T. R. Mosmann. 1987. The effect of BSFl and IFN-y on mouse immunoglobulin isotype expression. In Immune Regulation by Characterized Polypeptides. Alan R. Liss, Inc., New York. 523-532.
5. Snapper, C. M., E D. Finkelman, and W. E. Paul. 1988. Differential regulation of IgG1 and IgE synthesis by interleukin 4. J Exp. Med. 167: 183.
6. Layton, J. E., E. S. Vitetta, J. W. Uhr, and P. H. Krammer. 1984. Clonal analysis of B cells induced to secrete IgG by T cell derived lymphokines. J Exp. Med. 160: 1850.
7. Isakson, P. L., E. Pure, E. S. Vitetta, and P. H. Krammer. 1982. T cell derived B cell differentiation factor(s). Effect on the isotype switch ofmurine B cells.J Exp. Med. 155: 734.
8. Savelkoul, H. F. J., D. A. Lebman, R. Benner, and R. L. Coffman. 1988. Increase of precursor frequency and clonal size of murine immunoglobulin E-secreting cells by interleukin 4. J Immunol. In press.
9. Tony, H. P., and D. C. Parker. 1985. Major histocompatibility complex-restricted polyclonal B cell responses resulting from helper T cell recognition of anti-immunoglobulin presented by small B lymphocytes. J Exp. Med. 161: 223.
10. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types ofmurine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 136: 2348.
11. Ohara, J., and W. E. Paul. 1985. Production of a monoclonal antibody to and molecular characterization of B-cell-stimulatory factor-1. Nature (Land.). 315: 333.
12. Coffman, R. L., andJ. Carty. 1986. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-y. J. Immunol. 136: 949.
13. Oi, V. T., P. P. Jones, J. W Goding, L. A. Herzenberg, and L. A. Herzenberg. 1978. Propertie s of monoclonal antibodies to mouse Ig allotypes, H-2, and la antigens. Curr. Top. Microbial. Immunol. 81: 115.
14. Ledbetter, J. A., and L. A. Herzenberg. 1979. Xenogenei c monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47: 63.
15. H 2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166: 1229.
16. Lefkovits, I., and H. Waldmann. 1979. Limiting Dilution Analysis of Cells in the Immune System. Cambridge University Press, Cambridge. 30.
17. Fazekas de St. Groth, S. 1982. Evaluation of limiting dilution assays. J Immunol Methods. 49: R11.
18. Coffman, R. L., B. W. P. Seymour, D. A. Lehman, D. D. Hiraki, J. A. Christiansen, B. Shrader, H. M. Cherwinski, H. F. J. Savelkoul, F. D. Finkelman, M. W. Bond, and T. R. Mosmann. 1988. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102: 5.
19. Lichtman, A. H., H. P. Tony, D. C. Parker, and A. K. Abbas. 1987. Antigen presentation by hapten specific B lymphocytes. IV. Comparative ability of B cells to present specific antigens and anti-immunoglobulin antibody. J. Immunol. 138: 2822.
20. Pike, B. L., M. R. Alderson, and G. J. V. Nossal. 1987. T-independent activation of single B cells: An orderly analysis of overlapping stages in the activation pathway. Immunol. Rev. 99: 119.
21. Pike, B. L., and G. J. V. Nossal. 1985. A high efficiency cloning system for single haptenspecific B cells that is suitable for the assay of putative growth and differentiation factors. Proc. Nail. Acad. Sci. USA. 82: 3395.
22. Swain, S. L., and R. W. Dutton. 1987. Consequences of the direct interaction of helper T cells with B cells presenting antigen. Immunol. Rev. 99: 263.
23. Boom, W. H., D. Liano, and A. K. Abbas. 1988. Heterogeneity of helper inducer T lymphocytes. II. Effects of IL-4 and IL-2 producing T cell clones on resting B lymphocytes. J. Exp. Med. 167: 1350.
24. Finkelman, F. D., I. M. Katona, J. F Urban, C. M. Snapper, J. Ohara, andW. E. Paul. 1986. Suppression of in viva polyclonal IgE responses by monoclonal antibody to the lymphokine B cell stimulatory factor 1. Proc. Nail. Acad. Sci. USA. 83: 9675.
25. Radbruch, A., W. Muller, and K. Rajewsky. 1986. Class switch recombination is IgG, specific on active and inactive IgH loci of IgG,-secreting B cell blasts. Proc. Nail. Acad. Sci. USA. 83: 3954.
26. Snapper, C. M., F. D. Finkelman, and W. E. Paul. 1988. Regulation of IgG, and IgE production by interleukin 4. Immunol. Rev. 102: 51.
27. Lanzavecchia, A. 1983. One out of five peripheral blood B lymphocytes is activated to high rate Ig production by human alloreactive T cell clones. Eur J. Immunol. 13: 820.
28. Lanzavecchia, A., and B. Parodi. 1984. In vitro stimulation of IgE production at a single precursor level by human alloreactive T helper clones. Clin. Exp. Immunol. 55: 197.
29. Teale, J. M., F. T. Liu, and D. H. Katz. 1981. A clonal analysis of the IgE response and its implications with regard to isotype commitment., J Exp. Med. 153: 783.
30. Clough, E. R., andJ. J. Cebra. 1983. Interrelationshi p ofprimed B cells with the potential for IgE and/or IgA expression. Mol. Immunol. 20: 903.