Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor

European Journal of Pharmacology

Volumn 154, Issue 1, 1988, Pages 85-87

  Birch, Phillip J ^a   Grossman, Carol J ^a   Hayes, Ann G ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Kynurenate; NMDA receptor antagonists; Strychnine insensitive glycine receptors

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR; DEXTRO SERINE; GLYCINE; KAINIC ACID; KYNURENIC ACID; N METHYL DEXTRO ASPARTIC ACID; STRYCHNINE;

ANIMAL CELL; DEPOLARIZATION; DRUG ANTAGONISM; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD;

ANIMAL; ASPARTIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE; IN VITRO; KYNURENIC ACID; N-METHYLASPARTATE; RATS; RATS, INBRED STRAINS; RECEPTORS, GLYCINE; RECEPTORS, NEUROTRANSMITTER; SERINE; STRYCHNINE;

EID: 0023783911     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(88)90367-6     Document Type: Article

References (5)

1. High affinity uptake of transmitters: studies on the uptake of L-aspartate, GABA, L-glutamate and glycine in the cat spinal cord
2. Pharmacology of excitatory amino acid receptors in rat spinal cord
3. 3H]D-AP5 binding sites on brain membranes and anticonvulsant activity
4. Glycine potentiates the NMDA responses in cultured mouse brain neurons
5. Complex interactions between a glycine binding site and NMDA receptors