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Diol 1 is now manufactured by ICI Pharmaceuticals and is available in multigram quantities [ICI Fine Chemicals, P.O. Box 42 Hexagon House, Blackley, Manchester M9 3DA, England].
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Johnson, C. R.; Penning, T. D. J. Am. Chem. Soc. 1986, 108, 5655. See also: Medich, J. R.; Kunnen, K. B.; Johnson, C. R. Tetrahedron Lett. 1987, 28, 4131 for the synthesis of neplanocin A from enone 5.
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0000600197
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The stereochemical assignment for these compounds has been made in analogy with that of epoxides of benzenediols
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For epoxidation of benzenediols, see
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The stereochemical assignment for these compounds has been made in analogy with that of epoxides of benzenediols. For epoxidation of benzenediols, see: Ley, S. V.; Sternfeld, F.; Taylor, S. Tetrahedron Lett. 1987, 28, 225.
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The aldol-type condensation of carbonyl compounds with alumina has been reported. See, for example: Hudlicky, T.; Srnak, T. Tetrahedron Lett. 1981, 22, 3351. Muzart, J. Synthesis 1982, 60. Posner, G, H. Angew. Chem. 1978, 90, 527; Angew. Chem., Int. Ed. Engl. 1978, 17, 487.
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