γ‐Hydroxybutyrate Model of Generalized Absence Seizures: Further Characterization and Comparison with Other Absence Models

Epilepsia

Volumn 29, Issue 4, 1988, Pages 361-368

  III, O Carter Snead ^a,b,c  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^b Inserm U 44 ^*  (United States)

^c CENTRE DE NEUROCHIMIE   (France)

Author keywords

Electroencephalography; GABA; Neurologic model; Seizure; Hydroxybutyrate

Indexed keywords

4 HYDROXYBUTYRIC ACID; ETHOSUXIMIDE; GAMMA BUTYROLACTONE; PENICILLIN G; PENTETRAZOLE;

ABSENCE; AGED; ANIMAL EXPERIMENT; BIOLOGICAL MODEL; ELECTROENCEPHALOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMAL; BEHAVIOR, ANIMAL; COMPARATIVE STUDY; DISEASE MODELS, ANIMAL; HYDROXYBUTYRATES; MALE; PENTYLENETETRAZOLE; RATS; RATS, INBRED STRAINS; SEIZURES; SODIUM OXYBATE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023780307     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1988.tb03732.x     Document Type: Article

References (77)

1. γ‐Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes
2. Electroencephalographic and pathophysiologic features of rat parenteral penicillin epilepsy
3. Antagonism of gammahydroxybutyric acid‐induced frequency shifts in the cortical EEG of rats by dipropyl acetate
4. Concepts of absence epilepsies: Discrete syndromes or biological continuum?
5. Neurophysiology, neuropharmacology, and behavioral relationships of visual system evoked after discharges: a review
6. Ketamine activation of experimental corticoreticular epilepsy
7. Properties of gamma‐aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions
8. Action of inhibitory amino acids on acute epileptic foci: an electrographic study
9. The role of GABAergic mechanisms in epilepsies
10. The THIP‐induced model of bilateral synchronous spike and wave in rodents
11. The perspective of GABA replenishment therapy in the epilepsies: a critical evaluation of hopes and concerns
12. Ethosuximide mechanisms of action
13. Spike‐wave rhythms in cat cortex induced by parental penicillin II. Cellular features
14. Differential effects of convulsive drugs on photically evoked afterdis‐charge parameters
15. Petit mal seizure spikes in olfactory bulb and cortex caused by runaway inhibition after exhaustion of excitation
16. The role of inhibitory pathways in petit mal epilepsy
17. Intracellular recordings in peri‐cruciate neurons during spike and wave discharges of feline generalized penicillin epilepsy
18. Generalized epilepsy with spike and wave discharges: a reinterpretation of its electrographic and clinical manifestations
19. Electrophysiology of generalized epilepsy
20. Generalized penicillin epilepsy in the cat: effects of intracarotid and intra vertebral pentylenetetrazol and amobarbital injections
21. Antagonism of gamma‐hydroxybutyrate‐induced hypersynchronization in the EcoG of rat by anti‐petit mal drugs
22. Slow wave sleep and a state resembling absence epilepsy induced in the rat by 7‐hydroxybutyrate
23. 3H]‐hydroxybutyric acid by rat brain
24. Penicillin spikes in rats: Limitations of a single model for the study of anticonvulsants
25. Response of generalized penicillin epilepsy in the cat to ethosuximide and diphenyl‐hydantoin
26. Distinction between normal and epileptic rhythms in rodent sensorimotor cortex
27. Anticonvulsant sensitivity of absence seizures in the tottering mutant mouse
28. The epileptic nature of rodent electrocortical polyspiking is still unproven
29. The role of GAB A and excitatory amino acids in the development of the leptazol‐induced epileptogenic EEG
30. Multiple response of the visual cortex of the rat to photic stimulation
31. Effects of systemically applied GABA agonists and antagonists on wave‐spike ECoG activity in rat
32. Flash‐evoked afterdis‐charge in rat as a model of the absence seizure: dose‐response studies with therapeutic drugs
33. Spontaneous EEG paroxysms in the rat: effects of psychotropic and alpha‐adrenergic agents
34. Neuronal sensitivity to GABA and glutamate in generalized epilepsy with spike and wave discharges
35. Antiepileptic drug development: II. Anticonvulsant drug screening
36. Improved pharmacological activity via prodrug modification: Comparative pharmacokinetics of sodium γ‐hydroxybutyrate and γ‐butyrolactone
37. Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs
38. Pentylenetetrazole and penicillin are selective antagonists of GABA‐mediated post‐synaptic inhibition in cultured mammalian neurons
39. Ontogenetic development of rhythmic thalamocortical phenomena in the rat
40. A model of chronic spontaneous petit mal‐like seizures in the rat: comparison with pentylenetetrazole‐induced seizures
41. Attempts to produce spike‐wave complexes in the electrocorticogram of the rat
42. Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat
43. Effects of drugs affecting noradrenergic neurotransmission in rats with spontaneous petit mal‐like seizures
44. Effects of γ‐acetylenic GABA and 7‐vinyl GABA on metrazol‐activated, and kindled seizures
45. Antiepileptic effects of amphetamine may require GABA (benzodiazepine) activity
46. Development of the thalamocortical augmenting response in the kitten
47. Pathophysiology of generalized photosensitive epilepsy in the cat
48. Interactions of penta methylene tetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine‐GABA receptor‐ionophore complex
49. Spontaneous generalized spike‐wave discharges in the electrocorticograms of albino rats
50. γ‐Butyrolactone and γ‐hydroxybutyric acid: II. The pharmacologically active form
51. Conversion in vivo of γ ‐aminobutyric to γ ‐hydroxybutyric acid in the rat
52. Synchrony among rhythmical facial tremor, neocortical alpha waves and thalamic non‐sensory neuronal bursts in intact awake rats
53. The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy
54. Plasma and central nervous system kinetics of gamma‐hydroxybutyrate
55. Interactions of some anaesthetic convulsant, and anticonvulsant drugs at GABA‐benzodiazepine receptor‐ionophore complexes in rat brain. Synaptosomal membranes
56. Gamma‐hydroxybutyrate: correlation of serum and cerebrospinal fluid levels with elec‐troencephalographic and behavioral effects
57. Gamma‐hydroxybutyrate in the monkey. I. Electro‐encephalographic, behavioral, and pharmacokinetic studies
58. Gamma‐hydroxybutyrate in the monkey. II. Effect of chronic oral anticonvulsant drugs
59. Ontogeny of γ‐hydroxybutyric acid. II. Electroencephalographic effects
60. Gamma‐hydroxybutyric acid, gamma‐aminobutyric acid, and petit mal epilepsy
61. Noradrenergic mechanisms in 7‐hydroxybutyrate induced seizure activity
62. Gamma‐hydroxybutyric acid binding sites in rat and human brain synaptosomal membranes
63. γ ‐hydroxybutyric acid binding sites: evidence for coupling to a chloride anion channel
64. Laboratory evaluation of antiepileptic drugs
65. Muscimol and γ‐hydroxybutyrate: similar interactions with convulsant agents
66. A double blind crossover trial with progabide (SL76002) against placebo in patients with secondary generalized epilepsy
67. Neocortical and hippocampal activation in relation to behavior effects of atropine, eserine, phenothiaz‐ines, and amphetamine
68. Two types of electrocor‐tical paroxysms in an inbred strain of rats
69. Ontogeny of spontaneous petit mal‐like seizures in Wistar rats
70. Spontaneous spike and wave discharges in thalamus and cortex in a rat model of genetic petit mal‐like seizures
71. Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non‐convulsive epilepsy
72. Enhancement of spike and wave discharges by GABA‐mimetic drugs in rats with spontaneous petit mal‐like epilepsy
73. Effects of anticonvulsant drugs on substantia nigra pars reticulata neurons
74. Electrocorticographic activity elicited by metrazol during ontogenesis in rats