N-Acylphenylalanines anD Related Compounds. A New Class of Oral Hypoglycemic Agents

Journal of Medicinal Chemistry

Volumn 31, Issue 11, 1988, Pages 2092-2097

  Shinkai, Hisashi ^a   Toi, Koji ^a   Kumashiro, Izumi ^a   Seto, Yoshiko ^b   Fukuma, Mariko ^b   Dan, Katsuaki ^b   Toyoshima, Shigeshi ^b  

^a AJINOMOTO CO INC   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYLPHENYLALANINE; N (4 ETHYLBENZOYL) DEXTRO PHENYLALANINE; N BENZOYLPHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION;

ANIMAL; HYPOGLYCEMIC AGENTS; MICE; PHENYLALANINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0023776001     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00119a007     Document Type: Article

References (14)

1. Sarges, R. Prog. Med. Chem. 1981, 18, 191.
2. Cherner, R. Topics in Medicinal Chemistry; Rabinowitz, J. L., Myerson, R. M., Eds.; Wiley: New York, 1968; Vol. 2, p 195.
3. Sarges, R. Prog. Med. Chem. 1981, 18, 206.
4. Seto, Y.; Fukuma, M.; Dan, K.; Toyoshima, S. Jpn. J. Pharmacol. 1982, 32 (Suppl.), 269.
5. Seto, Y.; Dan, K.; Fukuma, K.; Fukushima, K.; Fujita, H. Jpn. J. Pharmacol. 1987, 43 (Suppl.), 152.
6. Bayer, H. O.; Gotthardt, H.; Huisgen, R. Chem. Ber. 1970,103, 2356.
7. Anderson, G. W.; Zimmerman, J. E.; Callahan, F. M. J. Am. Chem. Soc. 1964, 86, 1839.
8. Weygand, F.; Hoffmann, D.; Wünsch, E. Z. naturforsch. 1966, 21, 426.
9. Julian, P. L.; Karpel, W. J.; Magnani, A.; Meyer, E. W. J. Am. Chem. Soc. 1948, 70, 180.
10. Hein, G. E.; Niemann, C. J. Am. Chem. Soc. 1962, 84, 4487.
11. Brown, J. M.; Chaloner, P. A. J. Am. Chem. Soc. 1980, 102, 3040.
12. Vineyard, B. D.; Knowles, W. S.; Sabacky, M. J.; Bachman, G. L.; Weinkauff, D. J. J. Am. Chem. Soc. 1977, 99, 5946.
13. Schuller, W. H.; Niemann, C. J. Am. Chem. Soc. 1951, 73, 1644.
14. Huggett, A.; Nixon, D. A. Lancet 1957, 368.