Low molecular weight immunopotentiators

International Journal of Immunopharmacology

Volumn 10, Issue 5, 1988, Pages 497-510

  Ruszala Mallon, Veronica ^a   Lin, Yang I ^a   Durr, Frederick E ^a   Bosco Shang Wang, ^a  

^a Laboratory of Tumor Immunology Chemotherapy Research Department Medical Research Division American Cyanamid Company Lederle Laboratories Pearl River NY 10965 USA ^*

Author keywords

[No Author keywords available]

Indexed keywords

3,6 BIS(2 PIPERIDINOETHOXY)ACRIDINE; 4 (4 FLUOROPHENYLSULFONYL)ACETANILIDE; 9 (2 HYDROXY 3 NONYL)HYPOXANTHINE; AMIPRILOSE; AZIMEXON; BESTATIN; BROPIRIMINE; DIETHYLDITHIOCARBAMIC ACID; ETHYLENE 2,2' BIS(DITHIO)BIS(ETHANOL); FORPHENICINOL; LEVAMISOLE; METHISOPRINOL; MURAMYL DIPEPTIDE; PIMELAUTIDE; THYMOPENTIN; TUFTSIN;

CANCER; HUMAN; IMMUNOMODULATION; IMMUNOPOTENTIATION; INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ADJUVANTS, IMMUNOLOGIC; ANIMAL; HUMAN; IMMUNOTHERAPY; INFECTION; MOLECULAR WEIGHT; NEOPLASMS; VACCINATION;

EID: 0023770847     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/0192-0561(88)90066-5     Document Type: Article

References (137)

1. Thymopoietin pentapeptide treatment of primary immunodeficiencies
2. Levamisole and skin disease
3. Final results of multicenter placebo-controlled levamisole study of resectable lung cancer
4. Prevention of peroxidase mediated inhibition of neutrophil motility and lymphocyte transformation by levamisole, ompi, sodium aurothiomalate, indomethacin and tolmetin in vitro
5. Enhancement of resistance to Listeria monocytogenes infection in mice by pyrimidine analogs
6. Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble components
7. Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds
8. In vivo effect of isoprinosine on interleukin-2 production, lymphocyte mitogenesis and NK activity in normal and cyclophosphamide immunosuppressed mice
9. Sequential chemoimmunotherapy of colorectal cancer. Evaluation of methotrexate, Baker's Antifol and levamisole
10. Reduction of acute toxicity of cyclophosphamide and X-rays by the new immunomodulation compound BM 12.531
11. Aziridine dyes: preclinical and clinical studies
12. Effect of the immunomodulant 2-cyanaziridine derivative BM 41.332 on adjuvant arthritis in the rat. Arzneimittel-Forsch.
13. Inhibition of cis-platinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model
14. Prevention of spontaneous tumors of aged mice by immunopharmacologic manipulation: study of immune antitumor mechanisms
15. Anti-tuberculous activity of therafectin in C57 BL/6 mice
16. Initial clinical studies with tuftsin
17. Isoprinosine increases the antitumor action of interferon
18. Antiviral activity of isoprinosine in vitro and in vivo
19. Effect of imuthiol administration to normal or immunodeficient mice on IL-1 and IL-2 production and immune responses regulated by these mediators
20. Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs
21. Thymopentin treatment in AIDS and pre-AIDS patients
22. Selective inhibition by NPT 15392 of lymphocyte cyclic GMP phospodiesterase
23. Nonspecific activation of murine spleen cells in vitro by a synthetic immunoadjuvant (N-acetyl-muramyl-L-alanyl-D-isoglutamine)
24. In vitro effect of 40639-RP lauroyl tetrapeptide on the function of human helper T cells
25. DL-2-OXO-3(2-mercaptoethyl)-5-phenylimidazolidine A sulfhydryl metabolite of levamisole that interacts with microtubules
26. Biological effects of CL 246,738, a new immunomodulating agent
27. The covalent structure of an entire gamma G
28. Immunoenhancing activity of NPT 15392 a potental immune response modifier
29. Immune modulation by two antiviral isocytosines with different abilities to induce interferon
30. Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyl dipeptide
31. Efficacy of liposomes containing a lipophilic muramyl dipeptide derivative for activating the tumoricidal properties of alveolar macrophages in vivo
32. Improvement of natural killer activity and of T cells after thypopoietin pentapeptide therapy
33. Enhanced host defense mechanisms with levamisole in suckling rats
34. Lauroyltetrapeptide (RP-40639) and related lipopeptides: a novel class of synthetic immunomodulating agents
35. In vivo immunostimulation by tuftsin
36. Bestatin immunopharmacological properties in immunocompetent and aged immunodepressed mice
37. In vivo study in mice of the immunopharmacological properties of NPT 15392
38. In vivo immunomodulating properties of two synthetic agents: azimexone and Tuftsin
39. Interleukin 1, and interleukin 2 production in homosexual men. A controlled trial of therafectin SM-1213 a possible immunomodulator
40. A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin
41. The treatment of systemic lupus erythematosus (SLE) with the T-cell immunostimulant drug levamisole: a case report
42. The antiviral activity of isoprinosine
43. In vitro modulation of natural killer cell activity by isoprinosine NPT 15392 and interferon
44. Effects of levamisole and imidazole on lymphocyte proliferation and cyclic nucleotide levels
45. Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation
46. NPT 15392 a modulator of in vitro lymphocyte and macrophage functions
47. Effects of NPT 15392 in vitro on human leukocyte functions
48. Immunomodulating activities of ethylene-2,2′-bis(dithio)bis(ethanol) and related compounds. Effects on murine lymphocyte proliferation and functions in vitro
49. Immunostimulatory properties of ethylene-2,2′-bis(thio)bis(ethanol) and related compounds in vivo
50. ADA-202-718: a novel biological response modifier. II. Anti-tumor and anti-viral activities
51. Adjuvant activity of synthetic N-acetylmuramyl-l-alanyl-d-isoglutamine and related compounds on cell-mediated cytotoxicity in syngeneic mice
52. In vitro effects of two immunopotentiators, isoprinosine and NPT 15392 on murine T-cell differentiation and function
53. Studies on effects of forphenicinol on immune responses
54. Antitumor effect of forphenicinol, a low molecular weight immunomodifier, on murine transplantable tumors and microbial infections
55. Human monocyte—lymphocyte interaction and its enhancement by levamisole
56. Production of and response to interleukin-2 by cultured T cells: effects of lithuim chloride and other putative modulators
57. Enhancement of antibody formation against herpes simplex virus in mice by the T-cell mitogen bestatin
58. Human monocytes activated by immunomodulators in liposomes lyse herpes virus-infected but not normal cells
59. Preliminary Phase I study of bestatin in lung cancer cases
60. Human lymphocyte response to forphenicinol, a small molecular immunomodifier
61. Studies of thymopoietin pentapeptide (TP5) on experimental tumors I. TP5 relieves immunosuppression in tumor-bearing mice
62. Chemoimmunotherapy of B16 melanoma and P388 leukemia with cyclophosphamide and pyrimidinones
63. Potentiation of interferon effects on natural cytotoxicity of human peripheral blood cells by therafectin: a new macrophage activator
64. The activation of human monocytes by liposome-encapsulated muramyl dipeptide analogs
65. Cytotoxic and morphologic profile of endogenous and pyrimidinone-activated murine NK cells
66. Modulation of mouse natural killer cell activity by interferon and two antiviral isocytosines
67. Immunomodulation by the new synthetic compound BM 12.531, 2-[2-cyanaziridinyl-(1)]-[2-carbamoylaziridinyl-(1)]-propane (azimexone)
68. Protection by diethyldithiocarbamate against carbon tetrachloride lethality in rats and against carbon tetrachloride-induced lipid peroxidation in vitro
69. Immunomodulation by 1,2-o-isopropylidene-3-0-3′-(N′,N′-dimethyl-amino-n-propyl)-o-glucofuranose (SM-1213), a drug with antiviral activity
70. Potentiation of influenzal disease by immunisation with a synthetic double-standed RNA and the therapeutic effect of the immunomodulator therafectin (SM-1213)
71. Nouvelles syntheses et proprietes de la tuftsine
72. Muramyl dipeptide enhances in vitro peritoneal macrophage phagocytic activity
73. Total synthesis and adjuvant activity of bacterial peptidoglycan derivatives
74. Experimental and clinical studies of bestatin as an immunomodulator
75. The physiological role of gamma-globulin
76. Tuftsin (THR-LYS-PRO-ARG). A stimulator of all known functions of macrophage
77. Anti-tumor effect of the physiological tetrapeptide, tuftsin
78. Tuftsin: a hormone-like tetrapeptide with antimicrobial and antitumor activities
79. Effect of a small molecular immunomodifier, forphenicinol, in combination with cyclophosphamide on growth of and immunity to mammary tumor in C3H/HeN mice
80. Antitumor effect of forphenicinol, a small molecular immunomodifier, in combination with cyclophosphamide on various murine tumors
81. Increased sensitivity of IL-2 dependent cultured T cells and enhancement of in vitro production by human lymphocytes treated with bestatin
82. Enhancement of antibody response to a natural fragment of Streptococcal M protein by murabutide administered to healthy volunteers
83. The immunomodulatory action of inosiplex in relation to its effects in experimental viral infections
84. Mechanism of host defense suppression induced by viral infection: mode of action of inosiplex as an antiviral agent
85. Effect of the immune modulators BM 12531 (azimexone) and BM 41332 on the subsets of T-lymphocytes in mice
86. Components of mycobacteria and muramyl dipeptide with adjuvant activity induce lymphocyte activating factor
87. Correlation of clinical and virus-specific immune responses following levamisole therapy of recurrent herpes progenitalis
88. Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide
89. Activation of alveolar macrophage tumoricidal activity and eradication of experimental metastases by freeze-dried liposomes containing a new lipophilic muramyl dipeptide derivative
90. Influenza-induced depression of monocyte chemotaxis: reversal by levamisole
91. Isoprinosine and imuthiol, two potentially active compounds in patients with acquired immunodeficiency syndrome-related complex symptoms
92. Clinical and immunological effects of imuthiol during chronic infections in man
93. Protection of mice from herpes simplex virus infection by 5-halo, 6-aryl-isocytosines
94. Effet immunostimulant d'un imidothiazole dans l'immunisation des souris contre l'infection par Brucella abortus. C. r.
95. Isoprinosine as an immunopotentiator
96. The effects of sodium diethyldithiocarbamate, azathioprine, cyclophosphamide, or hydrocortisone acetate administered alone or in association for 4 weeks on the immune responses of Balb/c mice
97. Phase I – II studies of sodium diethyl dithiocarbamate (DTC)
98. Immunologic activity of DTC: potential for cancer therapy
99. Differentiation and regulation of lymphocyte populations: evidence for immunopotentiator-induced T cell recruitment
100. The mode of action of imuthiol sodium diethyldithiocarbamate. A new role for the brain neocortex and the endocrine liver in the regulation of the T cell lineage
101. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer
102. Immunotherapy with levamisole in rheumatic diseases
103. Treatment of rheumatoid arthritis with levamisole: long-term results and immune changes
104. Reversal of tumor-induced immunosuppression by the immunomodulator, N-[4-[(4-fluorophenyl)sulfonyl]phenyl]acetamide (CL 259,763)
105. Effect of N-[4[(4-fluorophenyl)sulfonyl]phenyl]acetamide (CL 259,763) on interleukin levels in tumor bearing mice
106. Modulation of hematopoiesis and immune functions by N-[4-[4-(fluorophenyl)sulfonyl]phenyl]acetamide (CL 259,763) in mice treated with 5-fluorouracil (5-FU)
107. NPT 15392 immunorestorative effects in tumor-suppressed mice
108. Ability of the immunomodulating dipeptide bestatin to activate cytotoxic mononuclear phagocytes
109. Clinical and immunological effects of levamisole
110. A ramdomized trial of levamisole versus placebo as adjuvant therapy in malignant melanoma
111. Interferon induction by 5-halo-6-phenyl pyrimidines
112. 6-Aryl pyrimidinoles: interferon inducers-immunomodulators-antiviral and antineoplastic agents
113. Distribution and chemical forms of diethyldithiocarbamate and tetraethylthiuram disulphide (disulfiram) in mice in relation to radioprotection
114. The immunomodulating effect of BM 12.531 (azimexone) on normal and tumored mice: in vitro and in vivo studies
115. Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomers
116. Thymopoietin enhances the allogeneic response and cyclic GMP levels of mouse peripheral, thymus-derived lymphocytes
117. Immunomodulatory and therapeutic properties of bestatin in mice
118. Isoprinosine-induced T-cell differentiation and T-cell suppressor activity in humans
119. Immunostimulating compounds. Isoprinosine and NPT 15392
120. An in vitro study on the effects of isoprinosine on immune responses in cancer patients
121. Recent studies on antibiotics and small immunomodulators with potential usefulness in treating lung cancer: Part I—Antitumor antibiotics and their derivatives
122. Studies on low-molecular weight immunomodifiers produced by microorganisms: results of ten years effort
123. Immunostimulant activity of muramyl peptides in mouse viral infection model
124. Effects of levamisole on spontaneous rosette-forming cells in murine spleen
125. Preliminary characterization in mice of the effect of isoprinosine on the immune system
126. Restoration of the impaired lymphocyte stimulation in old people by thymopoietin pentapeptide
127. Induction of tumor-inhibitory macrophages with a novel synthetic immunomodulator, 3,6-bis (2-piperidinoethoxy)acridine trihydrochloride (CL 246,738)
128. The mechanism of action of 3,6-bis (2-piperidinoethoxy)acridine trihydrochloride (CL 246,738) in the potentiation of natural killer cells
129. Modulation of the immune response to tumors by a novel synthetic compound, N-[4-[4-(fluorophenyl)sulfonyl]phenyl]acetamide (CL 259,763)
130. 1, mice by carbon disulfide
131. Potentiation of the immune response to influenza virus subunit vaccines
132. 32–36
133. The effect of levamisole on human lymphocyte mediator production in vitro
134. Inosiplex, a stimulating agent for normal human T cells and human leukocytes
135. NPT 15392 a new synthetic immunomodulatory agent human in vitro and in vivo (cancer patients) effects