Liver and muscle insulin sensitivity, glycogen concentration and glycogen synthase activity in a rat model of non-insulin-dependent diabetes

Diabetologia

Volumn 31, Issue 5, 1988, Pages 304-309

  Kruszynska, Y T ^a   Home, P D ^b  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

glucose turnover; glycogen; glycogen synthase; Insulin sensitivity; intermediary metabolites; non insulin dependent diabetes; rat

Indexed keywords

GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; LACTIC ACID; PYRUVIC ACID; RADIOISOTOPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; EUGLYCEMIA; GLUCOSE BLOOD LEVEL; GLYCOLYSIS; INSULIN SENSITIVITY; LIVER; METHODOLOGY; MUSCLE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ANIMAL; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; FASTING; GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN; KINETICS; LIVER; LIVER GLYCOGEN; MALE; MUSCLES; RATS; RATS, INBRED STRAINS; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T;

EID: 0023764450     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF00277412     Document Type: Article

References (35)

1. Insulin resistance is a prominent feature of insulin dependent diabetes
2. Natural course of insulin resistance in type 1 diabetes
3. Hepatic and peripheral insulin resistance: a common feature of type II and type I diabetes mellitus
4. Arginine stimulated acute phase of insulin and glucagon secretion in diabetic subjects
5. Non-insulin dependent diabetes mellitus. Interplay between B-cell inadequacy and insulin resistance
6. Insulin therapy in obese, non-insulin dependent diabetes induces improvements in insulin action and secretion that are maintained for two weeks after insulin withdrawal
7. Insulin treatment reverses the insulin resistance of type II diabetes mellitus
8. Insulin binding in diabetes: relationships with plasma insulin levels and insulin sensitivity
9. An attempt to define the nature of chemical diabetes using a multidimensional analysis
10. Insulin resistance and impaired insulin secretion in subjects with a history of gestational diabetes mellitus
11. Insulin secretion and insulin action in non-insulin-dependent diabetes mellitus. Which defect is primary
12. Beta-cell dysfunction, rather than insulin insensitivity, is the primary defect in familial type 2 diabetes
13. In vivo hepatic and peripheral insulin sensitivity in rats with non-insulin dependent diabetes induced by streptozotocin: assessment with the glucose clamp technique
14. Correction of hyperglycaemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
15. Comparison of portal and peripheral insulin delivery on carbohydrate metabolism in streptozotocin diabetic rats
16. Comparison of portal and peripheral insulin delivery on lipid metabolism in streptozotocin diabetic rats
17. Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycaemia
18. In vivo insulin sensitivity in the rat determined by euglycaemic clamp
19. Determinations of blood sugar
20. Turnover and recycling of glucose in man during prolonged fasting
21. An improved procedure for assay of glycogen synthase and phosphorylase in rat liver homogenates
22. Glycogen determination with amyloglucosidase
23. Enzymatic fluorometric continuous flow assays for blood glucose, lactate, pyruvate, alanine, glycerol and 3-hydroxybutyrate
24. Insulin resistance: a common feature of diabetes mellitus
25. Preservation of islet function and morphology after transplantation into high dose streptozotocin diabetic rats
26. Muscle enzyme activity and insulin sensitivity in type I (insulin dependent) diabetes mellitus
27. The contribution of different organs and tissues of the rat to assimilation of glucose
28. Splanchnic and peripheral disposal of oral glucose in man
29. In vivo regulation of liver and skeletal muscle glycogen synthase activity by glucose and insulin
30. Development of insulin resistance in normal dogs following alloxan-induced insulin deficiency
31. Hepatic and peripheral insulin resistance following streptozotocin-induced deficiency in the dog
32. Acute — and late — phase insulin secretion and glucose tolerance in mild alloxan diabetes in dogs
33. Insulin resistance is a prominent feature of patients with pancreatogenic diabetes
34. Aspects of the pathogenesis of type 2 diabetes