The pulmonary effects of ozone and nitrogen dioxide alone and combined in healthy and asthmatic adolescent subjects

Toxicology and Industrial Health

Volumn 4, Issue 4, 1988, Pages 521-532

  Koenig, Jane Q ^a   Covert, David S ^a   Smith, Michael S ^a   Van Belle, Gerald ^a   Pierson, William E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

asthma; nitrogen oxide; ozone; pulmonary function

Indexed keywords

NITROGEN DIOXIDE; OZONE;

ADOLESCENT; ASTHMA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; INHALATION; LUNG FUNCTION; LUNG TOXICITY; MALE; NORMAL HUMAN;

ADOLESCENT; ASTHMA; CHILD; COMPARATIVE STUDY; EXERTION; FEMALE; HUMAN; MALE; NITROGEN DIOXIDE; OZONE; RESPIRATION; RESPIRATORY FUNCTION TESTS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; VITAL CAPACITY;

EID: 0023763368     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/074823378800400410     Document Type: Article

References (13)

1. Adams, W.C., Brookes, K.A. and Schelegle, E.S. (1987). Effects of NO2 alone and in combination with 03 on young men and women. J. Applied Physiol. 62: 1698-1704.
2. Bauer, M.A., Utell, M.J., Morrow, P.E., Speers, D.M. and Gibb, F.R. (1986). Inhalation of 0.3 ppm nitrogen dioxide potentiates exercise-induced bronchospasm in asthmatics. Am. Rev. Resp. Dis. 134: 1203-1208.
3. Dubois, A.B., Botelho, S.Y., Bedell, C.N., Marshall, R. and Comroe, J.H., JR. (1956). A rapid plethysmographic method for measuring thoracic gas volume; a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. J. Clin. Invest. 35: 322-326.
4. Eggleston, P.A., Rosenthal, R.P., Anderson, S.A., et al. (1979). Guidelines for the methodology of exercise challenge testing in asthmatics. Study group on exercise challenge, broncho-provocation committee. American Academy of Allergy. J. Allergy Clin. Immunol. 64: 642-645.
5. Ehrlich, R. (1980). Interaction between environmental pollutants and respiratory infections. Environ. Health Perspectives 35: 89-100.
6. ENVIRONMENTAL PROTECTION AGENCY, Environmental Criteria and Assessment Office. (1986). Air quality criteria for ozone and other photochemical oxidants EPA/6001/ 8-84/ 020aF
7. Folinsbee, L.J., Bedi, J.F. and Horvath, S.M. (1981). Combined effects of ozone and nitrogen dioxide on respiratory function in man. Am. Ind. Hyg. Assoc. J. 42: 534-541.
8. Goldman, M., Knudson, R.J., Mead, J., Peterson, N., Schwaber, J.R. and Wohl, M.E. (1970). A simplified measurement of respiratory resistance by forced oscillation. J. Appl. Physiol. 28: 113-116.
9. Kagawa, J. (1983). Respiratory effects of two-hour exposure with intermittent exercise to ozone, sulfur dioxide and nitrogen dioxide alone and in combination in normal subjects. Am. Ind. Hyg. Assoc. J. 44: 14-20.
10. Koenig, J.Q., Pierson, W.E. and Frank, R. (1980). Acute effects of inhaled SO2 plus NaCl droplet aerosol on pulmonary function in asthmatic adolescents. Environ. Res. 22: 145-153.
11. Koenig, J.Q., Covert, D.S., Marshall, S.G., Van Belle, G. and Pierson, W.E. (1987). The effects of ozone and nitrogen dioxide on pulmonary function in healthy and asthmatic adolescents. Am. Rev. Resp. Dis. 136: 1152-1157.
12. Mautz, W.J., Kleinman, M.T., McClure, T.R. and Phalen, R.F. (1985). Synergistic effects of inhaled ozone and nitrogen dioxide on lung damage in rats. Fed Proc 44: 1272 (Abstract).
13. Roger, L.J., Horstman,D.H., McDonnell, W.F., Kerhl, H., Seal, E., Chapman, R.S. and Massaro, E.J. (1985). Pulmonary effects in asthmatics exposed to 0.3 ppm NO2 during repeated exercise. Toxicologist 5: 70 (Abstract).