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Volumn 29, Issue 47, 1988, Pages 6043-6046

Palladium catalysis in cephalosporin chemistry: A versatile new approach to 3-substituted cephems

Author keywords

[No Author keywords available]

Indexed keywords

CEPHALOSPORIN DERIVATIVE;

EID: 0023763363     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)82260-1     Document Type: Article
Times cited : (65)

References (16)
  • 2
    • 0001728368 scopus 로고
    • Synthesis of C(3)-Alkyl Cephems
    • For a precedent on organometallic coupling at C(3) see
    • (1985) HETEROCYCLES , vol.23 , pp. 1901
    • Spry1    Bhala2
  • 8
    • 84914297340 scopus 로고    scopus 로고
    • 2 at −78°C.
  • 9
    • 84914297339 scopus 로고    scopus 로고
    • Godschalx, J.; Stille, J.K.; Tetrahedron Lett. 1980, 2599.
  • 10
    • 84914297338 scopus 로고    scopus 로고
    • Use of LiBr or LiI led to the rapid formation of the Δ-2 3-halocephems analogous to compound 5. This reaction was not catalyzed by palladium. Our coupling took place at appreciable rate (although rather slowly) even without any halide source. Full details will appear in due course.
  • 13
    • 84914297337 scopus 로고    scopus 로고
    • Rates for a number of ligands were determined by a quantitative reverse-phase (C-18) HPLC method.
  • 14
    • 84914297336 scopus 로고    scopus 로고
    • Trost, B.M.; Verhoeven, T.R. in “Comprehensive Organometallic Chemistry”; Wilkinson,G.; Stome, F.G.A.; Abel, E.W. Eds. ; Pergamon Press: New York; Vol. 8, 799.
  • 15
    • 84914297335 scopus 로고    scopus 로고
    • We have observed an even more substantial rate enhancement in a related study: Farina, V.; Baker, S.R.; Bengini, D.A.; Sapino, C., submitted for publication.
  • 16
    • 84914297334 scopus 로고    scopus 로고
    • 2. All new compounds were characterized by elemental analysis, NMR and mass spectroscopy.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.