Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes

International Journal of Radiation Biology

Volumn 54, Issue 6, 1988, Pages 911-928

  Arlett, Colin F ^a   Green, Michael H L ^a   Priestley, Anne ^a   Harcourt, Susan A ^a   Mayne, Lynne V ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RADIOISOTOPE;

ATAXIA TELANGIECTASIA; CELL CULTURE; CELL SURVIVAL; CELL TRANSFORMATION; CYTOLOGY; FIBROBLAST; GAMMA RADIATION; HEREDITY; HUMAN; IMMORTALIZATION; NORMAL HUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; SIMIAN VIRUS 40;

ATAXIA TELANGIECTASIA; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION, VIRAL; COBALT RADIOISOTOPES; COMPARATIVE STUDY; FIBROBLASTS; GAMMA RAYS; HETEROZYGOTE; HUMAN; IN VITRO; RADIATION TOLERANCE; SIMIAN VIRUS 40; SKIN; SUPPORT, NON-U.S. GOV'T;

EID: 0023757362     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553008814552321     Document Type: Article

References (37)

1. Survey of radiosensitivity in a variety of human cell strains
2. An assessment of the radiosensitivity of ataxia-telangiectasia heterozygotes
3. The detection of gene mutations in cultured mammalian cells
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5. Ataxia-telangiectasia: evaluation of radiosensitivity in cultured skin fibroblasts as a diagnostic test
6. Radiosensitivity in cultured human fibroblasts
7. Defective repair of alkylated DNA by human tumour and SV-40 transformed human cell strains
8. Abnormal sensitivity of some Cockayne's syndrome cell strains to UV- and gamma-rays. Association with a reduced ability to repair potentially lethal damage
9. Re-evaluation of in vitro radiosensitivity of human fibroblasts of different genetic origins
10. Mean inactivation dose: a useful concept for intercomparison of human cell survival curves
11. Activated human N-ras oncogene enhances x-irradiation repair of mammalian cells in vitro less effectively at low dose rate
12. Transformation-sensitive proteins of REF52 cells detected by computer-analysed two-dimensional gel electrophoresis
13. Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium
14. An attempt to transfer radiation resistance to an ataxia-telangiectasia cell line
15. The serial cultivation of human diploid cell strains
16. Untransformed xeroderma pigmentosum cells are not hypersensitive to sister-chromatid exchange production by ethylmethanesulphonate—implications for the use of transformed cell lines and for the mechanism by which SCE arise
17. Transformation and repair replication in lymphocytes from ataxia telangiectasia
18. Phenotypic manifestations of ataxia-telangiectasia
19. Isolation of a human teratoma cell line which expresses F9 antigen
20. Limited and unlimited growth of SV40-transformed cells from human diploid MRC-5 fibroblasts
21. Radiosensitivity of human T-lymphocytes proliferating in long term culture
22. Theory of dose-effect relations
23. Tissue culture model of transitional cell carcinoma: characterisation of twenty-two human urothelial cell lines
24. Efficient immortalization and morphological transformation of human fibroblasts by transfection with SV40 DNA linked to a dominant marker
25. Characterisation of mutant human fibroblast cultures transformed with simian virus 40
26. Establishment and characterization of a permanent pSV ori- transformed ataxia-telagiectasia cell line
27. The radiosensitivity of cultured human and mouse keratinocytes
28. Differential sensitivities to gamma radiation of human bladder and testicular cell lines
29. Gamma-ray hypersensitivity and faulty DNA repair in cultured cells from humans exhibiting familial cancer proneness
30. Activation of mouse genes in transformed cells
31. Colony-forming ability of ataxia-telangiectasia skin fibroblasts is an indicator of their early senescence and increased demand for growth factors
32. The ras oncogenes increase the intrinsic resistance of NIH3T3 cells to ionising radiation
33. Ataxia-telangiectasia, a human mutation with abnormal radiation sensitivity
34. 6-ethylguanine elimination from DNA in normal human fibroblast and xeroderma pigmentosum cell strains not transformed by SV40
35. Deficiencies in the catalase activity of xeroderma pigmentosum cell and simian virus 40-transformed human cell extracts
36. A new syndrome of immunodeficiency and increased cellular sensitivity to DNA damaging agents
37. X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders