Pyrrolo[1,4]benzodiazepine Antitumor Antibiotics: Relationship of DNA Alkylation and Sequence Specificity to the Biological Activity of Natural and Synthetic Compounds

Chemical Research in Toxicology

Volumn 1, Issue 5, 1988, Pages 258-268

  Hurley, Laurence H ^a   Reck, Teri ^a   Langley, David R ^a   Thurston, David E ^b   Holden, Kenneth G ^c   Hertzberg, Robert P ^c   Hoover, John R E ^c   Gallagher, Gregory ^c   Faucette, Leo F ^c   Mong, Shau Ming ^c   Johnson, Randall K ^c  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^c SmithKline Beecham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAMYCIN; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; PYRROLO[1,4]BENZODIAZEPINE DERIVATIVE; TOMAYMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; COVALENT BOND; CYTOSTASIS; CYTOTOXICITY; DNA ALKYLATION; DNA BINDING; LD 50; LEUKEMIA; MELANOMA CELL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALKYLATION; ANTIBIOTICS, ANTINEOPLASTIC; BASE SEQUENCE; BENZODIAZEPINES; BINDING SITES; COMPARATIVE STUDY; DNA; MOLECULAR SEQUENCE DATA; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023755904     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx00005a002     Document Type: Article

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