Inherited susceptibility to insulin-dependent diabetes is associated with HLA-DR1, while DR5 is protective

Autoimmunity

Volumn 1, Issue 3, 1988, Pages 197-205

  Maclaren, Noel ^a   Riley, William ^a   Skordis, Nicos ^a   Atkinson, Mark ^a   Spillar, Rebecca ^a   Silverstein, Janet ^a   Klein, Ronald ^b   Vadheim, Constance ^c   Rotter, Jerome ^c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

HLA; Insulin dependent diabetes; Susceptibility

Indexed keywords

HLA DR ANTIGEN;

DISEASE PREDISPOSITION; GENETIC PREDISPOSITION; HEREDITY; HLA SYSTEM; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, INSULIN-DEPENDENT; DISEASE SUSCEPTIBILITY; GENE FREQUENCY; HLA-DR ANTIGENS; HLA-DR1 ANTIGEN; HLA-DR5 ANTIGEN; HUMAN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023754005     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916938808997164     Document Type: Article

References (41)

1. Histocompatibility antigens (HLA), lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus
2. HLA antigens and diabetes mellitus
3. HLA system and diabetes mellitus
4. HLA in Grave's disease and in diabetes mellitus
5. HLA-D and DR antigens in genetic analysis of insulin dependent diabetes mellitus
6. The genetic susceptibility to type I (insulin dependent) diabetes; analysis of the HLA-DR association
7. HLA antigens of insulin dependent diabetes
8. Inherited susceptibility to autoimmune Addison's disease is linked to HLA-DR3 and/or DR4, except when associated with type I autoimmune polyglandular syndrome
9. Extended major histocompatibility complex haplotypes in type I diabetes mellitus
10. Susceptibility to IDDM is worked by MHC supratypes rather than individual alleles
11. A novel type of T-T cell interaction removes the requirement for I-B region in the H-2 complex
12. HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus
13. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
14. Cytotoxicity testing
15. A method to detect simultaneously two cell populations by two color fluorescence
16. On estimating the relation between blood group and disease
17. HLA antigens and disease: statistical and genetical considerations
18. Estimability and estimation in case-referent studies
19. The epidemiological approach to studies of association between HLA and disease. II. Estimation of absolute risks, etiological and preventative fractions
20. HLA-DR antigens in insulin-dependent diabetes
21. HLA-DR antigens and insulin-dependent diabetes mellitus in the west of Ireland
22. Susceptibility to insulin-dependent diabetes defined by restriction enzyme polymorphism of HLA-D region genomic DNA
23. Relation of insulin-dependent diabetes mellitus (IDD) and the HLA-linked SB system
24. Genetic heterogeneity of insulin-dependent (type I) diabetes mellitus: evidence from a study of extended haplotypes
25. Complement and HLA. Further definition of high-risk haplotypes in insulin-dependent diabetes
26. HLA-DR antigen frequencies in a North Indian type I diabetic population
27. HLA-system in Chinese children with insulin-dependent diabetes mellitus: a strong association with D3
28. HLA-genotype studies in juvenile insulin-dependent diabetes
29. An analysis of epidemiological data in HLA-typed diabetic children
30. HLA-DR specifications in Japanese with juvenile-onset insulin-dependent diabetes mellitus
31. Population genetic analyses of insulin dependent diabetes mellitus using HLA allele frequencies
32. HLA-DR antigens and unique serologic reactions in juvenile onset diabetes mellitus
33. HLA haplotype study of 53 juvenile insulin-dependent diabetic (IDD) families
34. Insulin-dependent diabetes mellitus
35. A family study of the association between insulin dependent diabetes mellitus, autoantibodies and the HLA system
36. HLA-D region beta-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin dependent diabetic individuals
37. The molecular genetics of insulin dependent diabetes mellitus
38. Insulin-dependent diabetes - associated HLA-D region encoded determinants
39. Only one DQ-β restriction fragment pattern of each DR specificity is associated with insulin-dependent diabetes
40. HLA-DR2-associated Dw subtypes correlate with RFLP clusters: most DR2IDDM patients belong to one of these clusters