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Volumn 319, Issue 15, 1988, Pages 990-998

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME TRANSLOCATION; CHRONIC MYELOID LEUKEMIA; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVIEW;

EID: 0023753576     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198810133191506     Document Type: Review
Times cited : (740)

References (75)
  • 1
    • 0000286732 scopus 로고
    • A minute chromosome in human chronic granulocytic leukemia
    • Nowell PC, Hungerford DA. A minute chromosome in human chronic granulocytic leukemia. Science 1960; 132: 1497.
    • (1960) Science , vol.132 , pp. 1497
    • Nowell, P.C.1    Hungerford, D.A.2
  • 2
    • 0015694748 scopus 로고
    • A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973; 243: 290–3.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 3
    • 0019249351 scopus 로고
    • Chromosome abnormalities in human leukemia
    • Rowley Chromosome abnormalities in human leukemia. Annu Rev Genet 1980; 14: 17–39.
    • (1980) Annu Rev Genet , vol.14 , pp. 17-39
  • 4
    • 0019627646 scopus 로고
    • Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia
    • Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia. Cancer Genet Cytogenet 1981; 4: 111–37.
    • (1981) Cancer Genet Cytogenet , vol.4 , pp. 111-137
  • 5
    • 0014868883 scopus 로고
    • Cytogenetic studies in acute myelocytic leukemia with special emphasis on the occurrence of the Ph1 chromosome
    • Whang-Peng J, Henderson RS, Knutsen T, Freireich EJ, Gart JJ. Cytogenetic studies in acute myelocytic leukemia with special emphasis on the occurrence of the Ph1 chromosome. Blood 1970; 36: 448–57.
    • (1970) Blood , vol.36 , pp. 448-457
    • Whang-Peng, J.1    Henderson, R.S.2    Knutsen, T.3    Freireich, E.J.4    Gart, J.J.5
  • 6
    • 0020972981 scopus 로고
    • Translocation of the c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukemia
    • Bartram CR, de Klein A, Hagemeijer A, et al. Translocation of the c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukemia. Nature 1983; 306: 277–80.
    • (1983) Nature , vol.306 , pp. 277-280
    • Bartram, C.R.1    de Klein, A.2    Hagemeijer, A.3
  • 7
    • 0020972979 scopus 로고
    • Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
    • Heisterkamp N, Stephenson JR, Groffen J, et al. Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature 1983; 306: 239–42.
    • (1983) Nature , vol.306 , pp. 239-242
    • Heisterkamp, N.1    Stephenson, J.R.2    Groffen, J.3
  • 8
    • 0021346853 scopus 로고
    • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    • Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984; 36: 93–9.
    • (1984) Cell , vol.36 , pp. 93-99
    • Groffen, J.1    Stephenson, J.R.2    Heisterkamp, N.3    de Klein, A.4    Bartram, C.R.5    Grosveld, G.6
  • 9
    • 0021811764 scopus 로고
    • Structural organization of the bcr gene and its role in the Ph1 translocation
    • Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G. Structural organization of the bcr gene and its role in the Ph1 translocation. Nature 1985; 315: 758–61.
    • (1985) Nature , vol.315 , pp. 758-761
    • Heisterkamp, N.1    Stam, K.2    Groffen, J.3    de Klein, A.4    Grosveld, G.5
  • 10
    • 0021792151 scopus 로고
    • Distinguishing the Philadelphia chromosome of acute lymphoblastic leukemia from its counterpart in chronic myelogenous leukemia
    • Rodenhuis S, Smets LA, Slater RM, Behrendt H, Veerman AJP. Distinguishing the Philadelphia chromosome of acute lymphoblastic leukemia from its counterpart in chronic myelogenous leukemia. N Engl J Med 1985; 313: 51–2.
    • (1985) N Engl J Med , vol.313 , pp. 51-52
    • Rodenhuis, S.1    Smets, L.A.2    Slater, R.M.3    Behrendt, H.4    Veerman, A.J.P.5
  • 11
    • 0005497063 scopus 로고
    • Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph1+) acute lymphocytic leukemia
    • Erikson J, Griffin CA, ar-Rushdi A, et al. Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph1+) acute lymphocytic leukemia. Proc Natl Acad Sci USA 1986; 83: 1807–11.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1807-1811
    • Erikson, J.1    Griffin, C.A.2    ar-Rushdi, A.3
  • 12
    • 0022903177 scopus 로고
    • bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia
    • De Klein A, Hagemeijer A, Bartram CT, et al. bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia. Blood 1986; 68: 1369–75.
    • (1986) Blood , vol.68 , pp. 1369-1375
    • De Klein, A.1    Hagemeijer, A.2    Bartram, C.T.3
  • 13
    • 0023175233 scopus 로고
    • Molecular analysis of chromosome 22 breakpoints in adult Philadelphia-positive acute lymphoblastic leukaemia
    • Kurzrock R, Shtalrid M, Gutterman JU, et al. Molecular analysis of chromosome 22 breakpoints in adult Philadelphia-positive acute lymphoblastic leukaemia. Br J Haematol 1987; 67: 55–9.
    • (1987) Br J Haematol , vol.67 , pp. 55-59
    • Kurzrock, R.1    Shtalrid, M.2    Gutterman, J.U.3
  • 14
    • 0023568324 scopus 로고
    • Expression of c-abl in Philadelphia-positive acute myelogenous leukemia
    • Kurzrock R, Shtalrid M, Talpaz M, Kloetzer WS, Gutterman JU. Expression of c-abl in Philadelphia-positive acute myelogenous leukemia. Blood 1987; 70: 1584–8.
    • (1987) Blood , vol.70 , pp. 1584-1588
    • Kurzrock, R.1    Shtalrid, M.2    Talpaz, M.3    Kloetzer, W.S.4    Gutterman, J.U.5
  • 15
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow PJ, Jacobson RJ, Papayannopoulou T. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med 1977; 63: 125–30.
    • (1977) Am J Med , vol.63 , pp. 125-130
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 16
    • 0017652011 scopus 로고
    • Chromosomes and causation of human cancer and leukemia. XXIV. Unusual and complex Ph1 translocations and their clinical significance
    • Sonta SI, Sandberg AA. Chromosomes and causation of human cancer and leukemia. XXIV. Unusual and complex Ph1 translocations and their clinical significance. Blood 1977; 50: 691–7.
    • (1977) Blood , vol.50 , pp. 691-697
    • Sonta, S.I.1    Sandberg, A.A.2
  • 17
    • 0022356841 scopus 로고
    • Chronic myelogenous leukemia: a multivariate analysis of the associations of patient characteristics and therapy with survival
    • Kantarjian HM, Smith TL, McCredie KB, et al. Chronic myelogenous leukemia: a multivariate analysis of the associations of patient characteristics and therapy with survival. Blood 1985; 66: 1326–35.
    • (1985) Blood , vol.66 , pp. 1326-1335
    • Kantarjian, H.M.1    Smith, T.L.2    McCredie, K.B.3
  • 19
    • 0022256096 scopus 로고
    • The emerging genetics of acute lymphoblastic leukemia: clinical and biologic implications
    • Look AT. The emerging genetics of acute lymphoblastic leukemia: clinical and biologic implications. Semin Oncol 1985; 12: 92–104.
    • (1985) Semin Oncol , vol.12 , pp. 92-104
    • Look, A.T.1
  • 20
    • 0018656945 scopus 로고
    • Ph1-positive acute leukaemia and chronic granulocytic leukaemia: one or two diseases?
    • Catovsky D. Ph1-positive acute leukaemia and chronic granulocytic leukaemia: one or two diseases? Br J Haematol 1979; 42: 493–8.
    • (1979) Br J Haematol , vol.42 , pp. 493-498
    • Catovsky, D.1
  • 21
    • 0021047298 scopus 로고
    • Philadelphia chromosome and terminal transferase-positive acute leukemia: similarity of terminal phase of chronic myelogenous leukemia and de novo acute presentation
    • Jain K, Arlin Z, Mertelsmann R, et al. Philadelphia chromosome and terminal transferase-positive acute leukemia: similarity of terminal phase of chronic myelogenous leukemia and de novo acute presentation. J Clin Oncol 1983; 1: 669–76.
    • (1983) J Clin Oncol , vol.1 , pp. 669-676
    • Jain, K.1    Arlin, Z.2    Mertelsmann, R.3
  • 22
    • 0021014528 scopus 로고
    • Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes
    • Hoffmann FM, Fresco LD, Hoffman-Falk H, Shilo BZ. Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes. Cell 1983; 35: 393–401.
    • (1983) Cell , vol.35 , pp. 393-401
    • Hoffmann, F.M.1    Fresco, L.D.2    Hoffman-Falk, H.3    Shilo, B.Z.4
  • 23
    • 0023273390 scopus 로고
    • The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia
    • Bernards A, Rubin CM, Westbrook CA, Paskind M, Baltimore D. The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia. Mol Cell Biol 1987; 7: 3231–6.
    • (1987) Mol Cell Biol , vol.7 , pp. 3231-3236
    • Bernards, A.1    Rubin, C.M.2    Westbrook, C.A.3    Paskind, M.4    Baltimore, D.5
  • 24
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
    • Shtivelman E, Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 1985; 315: 550–4.
    • (1985) Nature , vol.315 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Canaani, E.4
  • 25
    • 0022997481 scopus 로고
    • Alternative splicing of RNAs transcribed from the human abl gene and from the bcr–abl fused gene
    • Shtivelman E, Lifshitz B, Gale RP, Roe BA, Canaani E. Alternative splicing of RNAs transcribed from the human abl gene and from the bcr–abl fused gene. Cell 1986; 47: 277–84.
    • (1986) Cell , vol.47 , pp. 277-284
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Roe, B.A.4    Canaani, E.5
  • 27
    • 0022182626 scopus 로고
    • Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products
    • Konopka JB, Witte ON. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products. Mol Cell Biol 1985; 5: 3116–23.
    • (1985) Mol Cell Biol , vol.5 , pp. 3116-3123
    • Konopka, J.B.1    Witte, O.N.2
  • 29
    • 0014837635 scopus 로고
    • Lymphosarcoma: virus-induced thymic-independent disease in mice
    • Abelson HT, Rabstein LS. Lymphosarcoma: virus-induced thymic-independent disease in mice. Cancer Res 1970; 30: 2213–22.
    • (1970) Cancer Res , vol.30 , pp. 2213-2222
    • Abelson, H.T.1    Rabstein, L.S.2
  • 30
    • 0021988833 scopus 로고
    • The complexity of virus–cell interactions in Abelson virus infection of lymphoid and other hematopoietic cells
    • Whitlock CA, Witte ON. The complexity of virus–cell interactions in Abelson virus infection of lymphoid and other hematopoietic cells. Adv Immunol 1985; 37: 73–98.
    • (1985) Adv Immunol , vol.37 , pp. 73-98
    • Whitlock, C.A.1    Witte, O.N.2
  • 31
    • 0022379552 scopus 로고
    • Activation of the abl oncogene in murine and human leukemias
    • Konopka JB, Wine ON. Activation of the abl oncogene in murine and human leukemias. Biochim Biophys Acta 1985; 823: 1–17.
    • (1985) Biochim Biophys Acta , vol.823 , pp. 1-17
    • Konopka, J.B.1    Wine, O.N.2
  • 32
    • 0022053951 scopus 로고
    • The minimum transforming region of c-abl is the segment encoding protein-tyrosine kinase
    • Prywes R, Foulkes JG, Baltimore D. The minimum transforming region of c-abl is the segment encoding protein-tyrosine kinase. J Virol 1985; 54: 114–22.
    • (1985) J Virol , vol.54 , pp. 114-122
    • Prywes, R.1    Foulkes, J.G.2    Baltimore, D.3
  • 33
    • 0023076865 scopus 로고
    • cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia
    • Hariharan IK, Adams JM. cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia. EMBO J 1987; 6: 115–9.
    • (1987) EMBO J , vol.6 , pp. 115-119
    • Hariharan, I.K.1    Adams, J.M.2
  • 34
    • 0022859356 scopus 로고
    • Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome
    • Mes-Masson AM, McLaughlin J, Daley GQ, Paskind M, Witte ON. Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome. Proc Natl Acad Sci USA 1986; 83: 9768–72.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 9768-9772
    • Mes-Masson, A.M.1    McLaughlin, J.2    Daley, G.Q.3    Paskind, M.4    Witte, O.N.5
  • 35
    • 0023121607 scopus 로고
    • Evidence that the Ph1 gene encodes a 160,000-dalton phosphoprotein with associated kinase activity
    • Stam K, Heisterkamp N, Reynolds FH Jr, Groffen J. Evidence that the Ph1 gene encodes a 160,000-dalton phosphoprotein with associated kinase activity. Mol Cell Biol 1987; 7: 1955–60.
    • (1987) Mol Cell Biol , vol.7 , pp. 1955-1960
    • Stam, K.1    Heisterkamp, N.2    Reynolds, F.H.3    Groffen, J.4
  • 36
    • 0022981185 scopus 로고
    • Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML): amplification of rearranged c-abl oncogenes in CML blast crisis
    • Collins SJ. Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML): amplification of rearranged c-abl oncogenes in CML blast crisis. J Clin Invest 1986; 78: 1392–6.
    • (1986) J Clin Invest , vol.78 , pp. 1392-1396
    • Collins, S.J.1
  • 37
    • 0023239781 scopus 로고
    • CML patients in blast crisis have breakpoints localized to a specific region of the BCR
    • Schaefer-Rego K, Dudek H, Popenoe D, et al. CML patients in blast crisis have breakpoints localized to a specific region of the BCR. Blood 1987; 70: 448–55.
    • (1987) Blood , vol.70 , pp. 448-455
    • Schaefer-Rego, K.1    Dudek, H.2    Popenoe, D.3
  • 38
    • 0023237325 scopus 로고
    • Application of a bcr-specific probe in the classification of human leukaemia
    • Boehm TL, Drahovsky D. Application of a bcr-specific probe in the classification of human leukaemia. J Cancer Res Clin Oncol 1987; 113: 267–72.
    • (1987) J Cancer Res Clin Oncol , vol.113 , pp. 267-272
    • Boehm, T.L.1    Drahovsky, D.2
  • 39
    • 0023749490 scopus 로고
    • Analysis of bcr gene and correlation with clinical course in Ph-positive chronic myelogenous leukemia
    • Shtalrid M, Talpaz M, Kurzrock R, et al. Analysis of bcr gene and correlation with clinical course in Ph-positive chronic myelogenous leukemia. Blood 1988; 72: 485–91.
    • (1988) Blood , vol.72 , pp. 485-491
    • Shtalrid, M.1    Talpaz, M.2    Kurzrock, R.3
  • 40
    • 0023605155 scopus 로고
    • Philadelphia-positive chronic myeloid leukemia with a chromosome 22 breakpoint outside the breakpoint cluster region
    • Selleri L, Narni F, Emilia G, et al. Philadelphia-positive chronic myeloid leukemia with a chromosome 22 breakpoint outside the breakpoint cluster region. Blood 1987; 70: 1659–64.
    • (1987) Blood , vol.70 , pp. 1659-1664
    • Selleri, L.1    Narni, F.2    Emilia, G.3
  • 41
    • 0023615339 scopus 로고
    • Utility of molecular genetic analysis of bcr rearrangement in the diagnosis of chronic myeloid leukemia
    • Benn P, Soper L, Eisenberg A, et al. Utility of molecular genetic analysis of bcr rearrangement in the diagnosis of chronic myeloid leukemia. Cancer Genet Cytogenet 1987; 29: 1–7.
    • (1987) Cancer Genet Cytogenet , vol.29 , pp. 1-7
    • Benn, P.1    Soper, L.2    Eisenberg, A.3
  • 42
    • 0023227540 scopus 로고
    • Breakpoints in Philadelphia chromosome (Ph1)-positive leukemias
    • Hirosawa S, Aoki N, Shibuya M, Onozawa Y. Breakpoints in Philadelphia chromosome (Ph1)-positive leukemias. Jpn J Cancer Res 1987; 78: 590–5.
    • (1987) Jpn J Cancer Res , vol.78 , pp. 590-595
    • Hirosawa, S.1    Aoki, N.2    Shibuya, M.3    Onozawa, Y.4
  • 43
    • 0023142769 scopus 로고
    • A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia
    • Kurzrock R, Shtalrid M, Romero R, et al. A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia. Nature 1987; 325: 631–5.
    • (1987) Nature , vol.325 , pp. 631-635
    • Kurzrock, R.1    Shtalrid, M.2    Romero, R.3
  • 44
    • 0023133732 scopus 로고
    • Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL
    • Clark SS, McLaughlin J, Crist WM, Champlin TR, Witte ON. Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL. Science 1987; 235: 85–8.
    • (1987) Science , vol.235 , pp. 85-88
    • Clark, S.S.1    McLaughlin, J.2    Crist, W.M.3    Champlin, T.R.4    Witte, O.N.5
  • 45
    • 0023105320 scopus 로고
    • A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia
    • Chan LC, Karhi KK, Rayter SI, et al. A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. Nature 1987; 325: 635–7.
    • (1987) Nature , vol.325 , pp. 635-637
    • Chan, L.C.1    Karhi, K.K.2    Rayter, S.I.3
  • 46
    • 0023636773 scopus 로고
    • Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia
    • Walker LC, Ganesan TS, Dhut S, et al. Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia. Nature 1987; 329: 851–3.
    • (1987) Nature , vol.329 , pp. 851-853
    • Walker, L.C.1    Ganesan, T.S.2    Dhut, S.3
  • 47
    • 0023649238 scopus 로고
    • Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia
    • Hermans A, Heisterkamp N, von Linden M, et al. Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia. Cell 1987; 51: 33–40.
    • (1987) Cell , vol.51 , pp. 33-40
    • Hermans, A.1    Heisterkamp, N.2    von Linden, M.3
  • 48
    • 0023182551 scopus 로고
    • Establishment and characterization of a cell line, TOM-1, derived from a patient with Philadelphia chromosome-positive acute lymphocytic leukemia
    • Okabe M, Matsushima S, Morioka M, et al. Establishment and characterization of a cell line, TOM-1, derived from a patient with Philadelphia chromosome-positive acute lymphocytic leukemia. Blood 1987; 69: 990–8.
    • (1987) Blood , vol.69 , pp. 990-998
    • Okabe, M.1    Matsushima, S.2    Morioka, M.3
  • 49
    • 0023902268 scopus 로고
    • Molecular heterogeneity of adult Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Schaefer-Rego K, Arlin Z, Shapiro LG, Mears JG, Leibowitz D. Molecular heterogeneity of adult Philadelphia chromosome-positive acute lymphoblastic leukemia. Cancer Res 1988; 48: 866–9.
    • (1988) Cancer Res , vol.48 , pp. 866-869
    • Schaefer-Rego, K.1    Arlin, Z.2    Shapiro, L.G.3    Mears, J.G.4    Leibowitz, D.5
  • 50
  • 51
    • 0021674862 scopus 로고
    • An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity
    • Konopka JB, Watanabe SM, Witte ON. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell 1984; 37: 1035–42.
    • (1984) Cell , vol.37 , pp. 1035-1042
    • Konopka, J.B.1    Watanabe, S.M.2    Witte, O.N.3
  • 52
    • 0021926819 scopus 로고
    • The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity
    • Kloetzer W, Kurzrock R, Smith L, et al. The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity. Virology 1985; 140: 230–8.
    • (1985) Virology , vol.140 , pp. 230-238
    • Kloetzer, W.1    Kurzrock, R.2    Smith, L.3
  • 53
    • 0023234119 scopus 로고
    • Identification of molecular variants of p210bcr-abl in chronic myelogenous leukemia
    • Kurzrock R, Kloetzer WS, Talpaz M, et al. Identification of molecular variants of p210bcr-abl in chronic myelogenous leukemia. Blood 1987; 70: 233–6.
    • (1987) Blood , vol.70 , pp. 233-236
    • Kurzrock, R.1    Kloetzer, W.S.2    Talpaz, M.3
  • 54
    • 0023159991 scopus 로고
    • Analysis of P210bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromosome-positive cells from chronic myelogenous leukemia patients
    • Maxwell SA, Kurzrock R, Parsons SJ, et al. Analysis of P210bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromosome-positive cells from chronic myelogenous leukemia patients. Cancer Res 1987; 47: 1731–9.
    • (1987) Cancer Res , vol.47 , pp. 1731-1739
    • Maxwell, S.A.1    Kurzrock, R.2    Parsons, S.J.3
  • 55
    • 0023410428 scopus 로고
    • In vitro transformation of immature hematopoietic cells by the p210 bcr/abl oncogene product of the Philadelphia chromosome
    • McLaughlin J, Chianese E, Witte ON. In vitro transformation of immature hematopoietic cells by the p210 bcr/abl oncogene product of the Philadelphia chromosome. Proc Natl Acad Sci USA 1987; 84: 6558–62.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6558-6562
    • McLaughlin, J.1    Chianese, E.2    Witte, O.N.3
  • 56
    • 0014733607 scopus 로고
    • Philadelphia-chromosome–positive and -negative chronic meylocytic leukemia
    • Ezdinli EZ, Sokal JE, Crosswhite L, Sandberg AA. Philadelphia-chromosome–positive and -negative chronic meylocytic leukemia. Ann Intern Med 1970; 72: 175–82.
    • (1970) Ann Intern Med , vol.72 , pp. 175-182
    • Ezdinli, E.Z.1    Sokal, J.E.2    Crosswhite, L.3    Sandberg, A.A.4
  • 57
    • 0021878957 scopus 로고
    • Philadelphia chromosome-negative chronic myelogenous leukemia: a morphological reassessment
    • Pugh WC, Pearson M, Vardiman JW, Rowley JD. Philadelphia chromosome-negative chronic myelogenous leukemia: a morphological reassessment. Br J Haematol 1985; 60: 457–67.
    • (1985) Br J Haematol , vol.60 , pp. 457-467
    • Pugh, W.C.1    Pearson, M.2    Vardiman, J.W.3    Rowley, J.D.4
  • 58
    • 0023002211 scopus 로고
    • Rearrangement in the breakpoint cluster region and the clinical course in Philadelphia-negative chronic myelogenous leukemia
    • Kurzrock R, Blick MB, Talpaz M, et al. Rearrangement in the breakpoint cluster region and the clinical course in Philadelphia-negative chronic myelogenous leukemia. Ann Intern Med 1986; 105: 673–9.
    • (1986) Ann Intern Med , vol.105 , pp. 673-679
    • Kurzrock, R.1    Blick, M.B.2    Talpaz, M.3
  • 59
    • 0022035970 scopus 로고
    • C-abl and bcr are rearranged in a Ph1-negative CML patient
    • Bartram CR, Kleihauer E, de Klein A, et al. C-abl and bcr are rearranged in a Ph1-negative CML patient. EMBO J 1985; 4: 683–6.
    • (1985) EMBO J , vol.4 , pp. 683-686
    • Bartram, C.R.1    Kleihauer, E.2    de Klein, A.3
  • 60
    • 0022504169 scopus 로고
    • Genomic diversity correlates with clinical variation in Ph1-negative chronic myeloid leukaemia
    • Morris CM, Reeve AE, Fitzgerald PH, Hollings PE, Beard ME, Heaton DC. Genomic diversity correlates with clinical variation in Ph1-negative chronic myeloid leukaemia. Nature 1986; 320: 281–3.
    • (1986) Nature , vol.320 , pp. 281-283
    • Morris, C.M.1    Reeve, A.E.2    Fitzgerald, P.H.3    Hollings, P.E.4    Beard, M.E.5    Heaton, D.C.6
  • 61
    • 0022319625 scopus 로고
    • bcr rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia
    • Bartram CR. bcr rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia. J Exp Med 1985; 162: 2175–9.
    • (1985) J Exp Med , vol.162 , pp. 2175-2179
    • Bartram, C.R.1
  • 63
    • 0023851442 scopus 로고
    • The correlation of breakpoint cluster region rearrangement and p210 phl/abl expression with morphological analysis of Ph-negative chronic myeloid leukemia and other myeloproliferative diseases
    • Wiedemann LM, Karhi KK, Shivji MK, et al. The correlation of breakpoint cluster region rearrangement and p210 phl/abl expression with morphological analysis of Ph-negative chronic myeloid leukemia and other myeloproliferative diseases. Blood 1988; 71: 349–55.
    • (1988) Blood , vol.71 , pp. 349-355
    • Wiedemann, L.M.1    Karhi, K.K.2    Shivji, M.K.3
  • 64
    • 85023260824 scopus 로고    scopus 로고
    • Philadelphia-negative chronic myelogenous leukemia with bcr rearrangement: molecular analysis, clinical characteristics, and response to therapy
    • (in press).
    • Shtalrid M, Talpaz M, Blick M, et al. Philadelphia-negative chronic myelogenous leukemia with bcr rearrangement: molecular analysis, clinical characteristics, and response to therapy. J Clin Oncol (in press).
    • J Clin Oncol
    • Shtalrid, M.1    Talpaz, M.2    Blick, M.3
  • 65
    • 0023915281 scopus 로고
    • Fusion of the bcr and c-abl genes in Ph1-positive acute lymphocytic leukemia with no rearrangement in the breakpoint cluster region
    • ar-Rushdi A, Negrini M, Kurzrock R, Huebner K, Croce CM. Fusion of the bcr and c-abl genes in Ph1-positive acute lymphocytic leukemia with no rearrangement in the breakpoint cluster region. Oncogene 1988; 2: 353–7.
    • (1988) Oncogene , vol.2 , pp. 353-357
    • ar-Rushdi, A.1    Negrini, M.2    Kurzrock, R.3    Huebner, K.4    Croce, C.M.5
  • 66
    • 0023898852 scopus 로고
    • Molecular abnormalities of bcr and c-abl in chronic myelogenous leukemia associated with a long chronic phase
    • Dreazen O, Berman M, Gale RP. Molecular abnormalities of bcr and c-abl in chronic myelogenous leukemia associated with a long chronic phase. Blood 1988; 71: 797–9.
    • (1988) Blood , vol.71 , pp. 797-799
    • Dreazen, O.1    Berman, M.2    Gale, R.P.3
  • 67
    • 0018979186 scopus 로고
    • Ph1-positive leukemia including chronic myelogenous leukemia
    • Rowley JD. Ph1-positive leukemia including chronic myelogenous leukemia. Clin Haematol 1980; 9: 55–86.
    • (1980) Clin Haematol , vol.9 , pp. 55-86
    • Rowley, J.D.1
  • 68
    • 0000538165 scopus 로고
    • Human c-myc oncogene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells
    • Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM. Human c-myc oncogene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA 1982; 79: 7824–7.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 7824-7827
    • Dalla-Favera, R.1    Bregni, M.2    Erikson, J.3    Patterson, D.4    Gallo, R.C.5    Croce, C.M.6
  • 69
    • 0021717486 scopus 로고
    • Genomic alterations involving the c-myc proto-oncogene locus during the evolution of a case of chronic granulocytic leukaemia
    • McCarthy DM, Rassool FV, Goldman JM, Graham SV, Birnie GD. Genomic alterations involving the c-myc proto-oncogene locus during the evolution of a case of chronic granulocytic leukaemia. Lancet 1984; 2: 1362–5.
    • (1984) Lancet , vol.2 , pp. 1362-1365
    • McCarthy, D.M.1    Rassool, F.V.2    Goldman, J.M.3    Graham, S.V.4    Birnie, G.D.5
  • 70
    • 0023217510 scopus 로고
    • Molecular characteristics of chronic myelogenous leukemia in blast crisis
    • Blick M, Romero P, Talpaz M, et al. Molecular characteristics of chronic myelogenous leukemia in blast crisis. Cancer Genet Cytogenet 1987; 27: 349–56.
    • (1987) Cancer Genet Cytogenet , vol.27 , pp. 349-356
    • Blick, M.1    Romero, P.2    Talpaz, M.3
  • 71
    • 0021253386 scopus 로고
    • Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells
    • Collins SJ, Kubonishi I, Miyoshi I, Groukine M. Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells. Science 1984; 225: 72–4.
    • (1984) Science , vol.225 , pp. 72-74
    • Collins, S.J.1    Kubonishi, I.2    Miyoshi, I.3    Groukine, M.4
  • 72
    • 0023140634 scopus 로고
    • bcr–abl RNA in patients with chronic myelogenous leukemia
    • Shtivelman E, Gale RP, Dreazen O, et al. bcr–abl RNA in patients with chronic myelogenous leukemia. Blood 1987; 69: 971–3.
    • (1987) Blood , vol.69 , pp. 971-973
    • Shtivelman, E.1    Gale, R.P.2    Dreazen, O.3
  • 73
    • 0023008216 scopus 로고
    • Persistence of chronic myelocytic leukemia despite delegation of rearranged bcr–abl sequences in blast crisis
    • Bartram CR, Janssen JW, Becher R, De Klein A, Grosveld G. Persistence of chronic myelocytic leukemia despite delegation of rearranged bcr–abl sequences in blast crisis. J Exp Med 1986; 164: 1389–96.
    • (1986) J Exp Med , vol.164 , pp. 1389-1396
    • Bartram, C.R.1    Janssen, J.W.2    Becher, R.3    De Klein, A.4    Grosveld, G.5
  • 74
    • 0022759778 scopus 로고
    • Comparison of constitutional and tumor-associated 11;22 translocation: nonidentical breakpoints on chromosomes 11 and 22
    • Griffin CA, McKeon C, Israel MA, et al. Comparison of constitutional and tumor-associated 11;22 translocation: nonidentical breakpoints on chromosomes 11 and 22. Proc Natl Acad Sci USA 1986; 83: 6122–6.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 6122-6126
    • Griffin, C.A.1    McKeon, C.2    Israel, M.A.3
  • 75
    • 0023136547 scopus 로고
    • Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA
    • Bell JC, Mahadevan LC, Colledge WH, Frackelton AR Jr, Sargent MG, Foulkes JG. Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA. Nature 1987; 325: 552–4.
    • (1987) Nature , vol.325 , pp. 552-554
    • Bell, J.C.1    Mahadevan, L.C.2    Colledge, W.H.3    Frackelton, A.R.4    Sargent, M.G.5    Foulkes, J.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.