Potential Contribution of Mild Pepsin Treatment at pH4 to the Viral Safety of Human Immunoglobulin Products

Vox Sanguinis

Volumn 55, Issue 2, 1988, Pages 75-80

  Reid, K G ^a   Cuthbertson, B ^b   Jones, A D L ^a   Mclntosh, R V ^a  

^a SCOTTISH NATIONAL BLOOD TRANSFUSION SERVICE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN G; PEPSIN A;

DRUG CONTAMINATION; HUMAN; PRIORITY JOURNAL; VIRUS INFECTION;

ANTIBODIES, VIRAL; DRUG CONTAMINATION; HUMAN; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; PEPSIN A; VIRUSES;

EID: 0023751812     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.1988.tb05140.x     Document Type: Article

References (24)

1. Safety of therapeutic immune globulin preparations with respect to transmission of human T‐lymphotropic virus type III/lymphadenopathy virus infection
2. Screening for antibodies to LAV/HTLVIII in recipients of immunoglobulin preparations
3. Hepatitis B in subjects treated with a drug containing immunoglobulins
4. Epidemic Hepatitis B caused by commercial human immunoglobulin
5. Transmission of hepatitis B by immune serum globulin
6. Different fates of hepatitis B markers during plasma fractionation. A clue to the infectivity of blood derivatives
7. Inactivation and partition of human T‐cell lymphotropic virus, type III, during ethanol fractionation of plasma
8. Elimination of infectious retroviruses during preparation of immunoglobulins
9. Non‐A, non‐B hepatitis occurring in agammaglobulinaemic patients after intravenous immunoglobulin
10. Non‐A, non‐B hepatitis and intravenous immunoglobulin
11. Non‐A, non‐B hepatitis after intravenous gammaglobulin
12. Non‐A, non‐B hepatitis and intravenous immunoglobulin
13. Serum ALT levels in patients with primary hypo‐gammaglobulinaemia receiving replacement therapy with intravenous immunoglobulin or fresh frozen plasma
14. Kistler/Nitschmann plasma fractionation methods
15. Non‐A, non‐B hepatitis from intravenous immunoglobulin
16. Immunofluorescent staining
17. Cell culture techniques for diagnostic virology
18. Some experience with intravenous immunoglobulin in Scotland
19. Rapid random donor screening for the selection of viral antibody‐containing blood donations
20. Freezing and thawing as a means of disassociating antigen bound to immobilised antibody
21. Recent research in freezing, drying and kinetics of thermal degradation of viruses
22. Inactivation of hepatitis B and Hutchinson strain non‐A, non‐B hepatitis viruses by exposure of Tween 80 and ether
23. Factors influencing the viral safety of intravenous immunoglobulin