Serotonergic properties of spiroxatrine enantiomers

Journal of Medicinal Chemistry

Volumn 31, Issue 10, 1988, Pages 1965-1968

  Nikam, Sham S ^a   Martin, Arnold R ^a   Nelson, David L ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; DOPAMINE 2 RECEPTOR; RADIOISOTOPE; SEROTONIN RECEPTOR; SPIROXATRINE;

ANIMAL CELL; DRUG RECEPTOR BINDING; ENANTIOMER; NONHUMAN;

ANIMAL; ANTIPSYCHOTIC AGENTS; BINDING SITES; DIOXANES; DIOXINS; MALE; RATS; RATS, INBRED STRAINS; RECEPTORS, SEROTONIN; SEROTONIN; SPIPERONE; SPIRO COMPOUNDS; STEREOISOMERISM; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023748365     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00118a017     Document Type: Article

References (25)

1. Pedigo, N. W.; Yamamura, H. I.; Nelson, D. L. J. Neurochem. 1981, 36, 220.
2. Nelson, D. L.; Taylor, E. W. Eur. J. Pharmacol. 1986, 124, 207.
3. Janssen, P. A. J. Belgian Patent 633, 914
4. Janssen, P. A. Chem. Abstr. 1964, 60, 15880f
5. Janssen, P. A. U.S. Patent 3 155 669.
6. Janssen, P. A. Chem. Abstr. 1965, 62, 9142e
7. Janssen, P. A. French Patent M2987.
8. Janssen, P. A. Chem. Abstr. 1965, 63, 8374f
9. Janssen, P. A. U.S. Patent 3 238 216.
10. Janssen, P. A. Chem. Abstr. 1966, 65, 8922.
11. Clark, R. D.; Kurz, L. J. Heterocycles 1985, 23, 2005.
12. Nelson, W. L.; Wennerstrom, J. E.; Dyer, D. C.; Engle, M. J. Med. Chem. 1977, 20, 887.
13. Andrews, P. R.; Lloyd, E. J. Prog. Med. Chem. 1986, 23, 91.
14. Hall, Z. W. Trends Neurosci. 1987, 10, 99.
15. Janssen, P. A. J.; Niemegeers, C. J. E.; Schellekens, K. H. L. Arzneim. Forsch. 1965, 15, 1196.
16. Nelson, D. L.; Killam, A. L.; Monroe, P. J.; Nikam, S. S.; Martin, A. R. Pharmacologist 1987, 29, 111.
17. Taylor, E. W.; Duckies, S. P.; Nelson, D. L. J. Pharmacol. Exp. Ther. 1986, 236, 118.
18. Nelson, D. L.; Monroe, P. J.; Lambert, G.; Yamamura, H. I. Life Sci. 1987, 41, 1567.
19. Van der Maelen, C. P.; Taylor, D. P.; Gehlbach, G.; Bison, M. S. Psychopharmacol. Bull. 1986, 22, 806.
20. Nelson, D. L.; Herbet, A.; Bourgoin, S.; Glowinski, J.; Hamon, M. Mol. Pharmacol. 1978, 14, 983.
21. Leysen, J. E.; Neimegeers, C. J. E.; Van Neuten, J. M.; Laduron, P. M. Mol. Pharmacol. 1982, 21, 301.
22. Hoyer, D.; Engel, G.; Kalkman, H. O. Eur. J. Pharmacol. 1985, 118, 13.
23. Sokoloff, P.; Brann, M.; Redouane, K.; Martres, M.-P.; Schwartz, J.-C.; Bouthenet, M.-L.; Sales, N.; Mann, A.; Hamdi, P.; Wermuth, C. G.; Roy, J.; Morgat, J.-L. Eur. J. Pharmacol. 1985, 107, 243.
24. Norman, A. B., Battaglia, G.; Creese, I. Mol. Pharmacol. 1985, 28, 487.
25. Cheng, Y.; Prusoff, W. H. Biochem. Pharmacol. 1973, 22, 3099.