Interactions of exercise, coagulation, platelets, and fibrinolysis-a brief review

Medicine and Science in Sports and Exercise

Volumn 20, Issue 5, 1988, Pages 439-446

  Bourey, Raymond E ^a   Santoro, Samuel A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aerobic training; Coagulation; Exercise; Fibrinolysis; Hemostasis; Platelet

Indexed keywords

AEROBIC CAPACITY; BLOOD CLOT LYSIS; BLOOD CLOTTING; EXERCISE; FIBRINOLYSIS; HUMAN; REVIEW; THEORETICAL STUDY; THROMBOCYTE; TRAINING;

BLOOD COAGULATION; BLOOD PLATELETS; EXERCISE; FIBRINOLYSIS; HUMAN; PHYSICAL ENDURANCE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023737933     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/00005768-198810000-00003     Document Type: Article

References (69)

1. BARTSCH, P., E. K. SCHMIDT, and P. W. STRAUB. Fibrinopeptide A after strenuous physical exercise at high altitude. J. Appl. Physiol. 53:40-43, 1982.
2. BERKARDA, B., G. AKOKAN, and U. DERMAN. Fibrinolytic response to physical exercise in males. Atherosclerosis 13:85-91, 1971.
3. BRITTON, B. J., W. G. WOOD, M. SMITH, C. HAWKEY, and M. H. IRVING. The effect of beta adrenergic blockade upon exercise-induced changes in blood coagulation and fibrinolysis. Thromb. Haemost. 35:396-402, 1976.
4. BROMMER, E. J. P., J. H. VERHEIJEN, G. T. G. CHANG, and D. C. RIJKEN. Masking of fibrinolytic response to stimulation by an inhibitor of tissue-type plasminogen activator in plasma. Thromb. Haemost. 52:154-156, 1984.
5. BROWN, J. E., R. F. BAUGH, and C. HOUGIE. Effect of exercise on the factor VIII complex: a correlation of the von Willebrand antigen and factor VIII coagulant antigen increase. Thromb. Res. 15:61-67, 1979.
6. BURGHUBER, O., H. SlNZINGER, K. SlLBERBAUER, C. WOLF, and P. HABER. Decreased prostacyclin sensitivity of human platelets after jogging and squash. Prostaglandins Med. 6:127-130, 1981.
7. CANNON, W. B. Bodily changes in pain, hunger, fear, and rage, 2nd Ed. New York: Appleton, 1929.
8. CASH, J. D. Effects of moderate exercise on the fibrinolytic system in normal young men and women. Br. Med. J. 2:502-506,1966.
9. CASH, J. D. and A. G. E. ALLAN. The fibrinolytic response to moderate exercise and intravenous adrenaline in the same subjects. Br. J. Haematol. 13:376-383, 1967.
10. COHEN, R. J., S. E. EPSTEIN, L. S. COHEN, and L. H. DENNIS. Alterations of fibrinolysis and blood coagulation induced by exercise and the role of beta adrenergic-receptor stimulation. Lancet i: 1264-1266, 1968.
11. COLLEN, D., N. SEMERARO, J. P. TRICOT, and J. VERMYLEN. Turnover of fibrinogen, plasminogen, and prothrombin during exercise in man. J. Appl. Physiol. 42:865-873, 1977.
12. DAVIS, G. L., C. F. ABILDGAARD, E. M. BERNAUER, and M. BRITTON. Fibrinolytic and hemostatic changes during and after maximal exercise in males. J. Appl. Physiol. 40:287-292, 1976.
13. DIMITRIADOU, C, A. DESSYPRIS, C. LOUIZOU, and T. MANDA-LAKI. Marathon Run II: effects on platelet aggregation. Thromb. Haemost. 37:451-455, 1977.
14. Dix, C. J., D. J. HASSALL, and K. R. BRUCKDORFER. The increased sensitivity of platelets to prostacyclin in marathon runners. Thromb. Haemost. 51:385-387, 1984.
15. DOUSTE-BLAZVI, P., P. SIE, B. BONEU, J. MARCO, N. ECHE, and P. BERNADET. Exercise-induced platelet activation in myocardial infraction survivors with normal coronary arteriogram. Thromb. Haemost. 52:297-300, 1984.
16. FERGUSON, E. W. and M. M. GUEST. Exercise, physical conditioning, blood coagulation and fibrinolysis. Thromb. Diasthes. Haemorrh. 31:63-71, 1974.
17. FERGUSON, E. W., C. F. BARR, and L. L. BERNIER. Fibrinogenolysis and fibrinolysis with strenuous exercise. J. Appl. Physiol. 47:1157-1161, 1979.
18. FERGUSON, E. W., L. L. BERNIER, G. R. BANTA, J. YU-YAHIRO, and E. B. SCHOOMAKER. Effects of exercise and conditioning on clotting and fibrinolytic activity in men. J. Appl. Physiol. 62:1416-1421, 1987.
19. FREEDMAN, M., N. ALTSZULER, and S. KARPATKIN. Presence of a nonsplenic platelet pool. Blood 50:419-425, 1977.
20. HAMPTON, J. W., A. WEIENBACH, G. E. SKYE, C. RUBENSTEIN, and F. B. TAYLOR. Hemophilia: modified by a post-exercise plasminogen activator. Thromb. Diasthes. Haemorrh. 26:612, 1971.
21. HAWKEY, C. M., B. J. BRITTON, W. G. WOOD, M. PEELE, and M. H. IRVING. Changes in blood catecholamine levels and blood coagulation and fibrinolytic activity in response to graded exercise in man. Br. J. Haematol. 29:377-384, 1975.
22. HUGHES, A. S. B., C. D. J. ILSLEY, and L. WILKINSON. Platelet activation during exercise-induced myocardial ischaemia. Thromb. Res. 26:425-430, 1982.
23. HUISVELD, I. A., C. KLUFT, A. J. H. HOSPERS, M. J. E. BERNINK, W. B. M. ERICH, and B. N. BOUMA. Effect of exercise and oral contraceptive agents on fibrinolytic potential in trained females. J. Appl. Physiol. 56:906-913, 1984.
24. HUNTER, J. A treatise on blood, inflammation, and gunshot wounds. London, 1794, p. 88.
25. HYERS, T. M., B. J. MARTIN, D. S. PRATT, R. B. DREISIN, and J. J. FRANKS. Enhanced thrombin and plasmin activity with exercise in man. J. Appl. Physiol. 48:821-825, 1980.
26. IATRIDIS, S. G. and J. H. FERGUSON. Effect of physical exercise on blood clotting and fibrinolysis. J. Appl. Physiol. 18:337-344, 1963.
27. IKKALA, E., G. MYLLYLÄ, and H. S. S. SARAJAS. Haemostatic changes associated with exercise. Nature 199:459-461, 1963.
28. KEBER, D. and M. STEGNAR. Exhaustion of arm fibrinolytic potential after repeated venous occlusions and local exercise. Thromb. Res. 28:693-704, 1982.
29. KEBER, D., M. STEGNAR, I. KEBER, and B. ACCETTO. Influence of moderate and strenuous daily physical activity on fibrinolytic activity of blood: possibility of plasminogen activator stores depletion. Thromb. Haemost. 41:745-755, 1979.
30. KLUFT, C, A. F. H. JIE, and R. A. ALLEN. Behavior and quantitation of extrinsic (tissue-type) plasminogen activator in human blood. Thromb. Haemost. 50:518-523, 1983.
31. KOCH, B., N. L. C. LUBAN, F. M. GALIOTO, JR., M. E. RICK, D. GOLDSTEIN, and J. F. KELLEHER, JR. Changes in coagulation parameters with exercise in patients with classic hemophilia. Am. J. Hematol. 16:227-233, 1984.
32. KOPITSKY, R. G., M. P. SWITZER, R. S. WILLIAMS, and P. A. MCKEE. The basis for the increase in factor VIII procoagulant activity during exercise. Thromb. Haemost. 49:53-57, 1983.
33. KORSAN-BENGSTEN, K., L. WILHELMSEN, and G. TIBBLIN. Blood coagulation and fibrinolysis in relation to degree of physical activity during work and leisure time. Acta Med. Scand. 193:73-77, 1973.
34. KRISTENSEN, S. D., E. B. SCHMIDT, H. R. ANDERSEN, and J. DYERBERG. Exercise decreases the platelet sensitivity to prostacyclin in patients with angina pectoris. Prostaglandins Leuko-trienes Med. 20:45-54, 1985.
35. 2in healthy men: effect of beta-adrenergic blockade. J. Cardiovasc. Pharmacol. 6:449-484, 1984.
36. LEHMANN, M. and J. KEUL. Physical activity and coronary heart disease: sympathetic drive and adrenaline-induced platelet aggregation. Int. J. Sports Med. 7(Suppl.):34-37, 1986.
37. LEHMANN, M., K. HASLER, E. BERGDOLT, and J. KEUL. Alpha-2-adrenoreceptor density on intact platelets and adrenaline induced platelet aggregation in endurance-and nonendurance-trained subjects. Int. J. Sports Med. 7:172-176, 1986.
38. 2-adrenergic receptors on platelets. Med. Sci. Sports. Exerc. 19:7-10, 1987.
39. MANDALAKI, T., A. DESSYPRIS, C, LOUIZOU, I. BOSSINAKOU, C. PANAHOTOPOULOU, and A. ANTONOPOULOU. Marathon run I: effects on blood coagulation and fibrinolysis. Thromb. Haemost. 37:444-455, 1977.
40. MANT, M. J., C. T. KAPPAGODA, and J. QUINLAN. Lack of effect of exercise on platelet activation and platelet reactivity. J. Appl. Physiol. 57:1333-1337, 1984.
41. MARCELLA, J. J., A. B. NICHOLS, L. L. JOHNSON, J. OWEN, D. S. REISON, K. L. KAPLAN, and P. J. CANNON. Exercise-induced myocardial ischemia in patients with coronary artery disease: lack of evidence for platelet activation or fibrin formation in peripheral venous blood. J. Am. Coll. Cardiol. 1:1185-1193, 1983.
42. MARSH, N. A. and P. J. GAFFNEY. Some observations on the release of extrinsic and intrinsic plasminogen activators during exercise in man. Haemostasis 9:238-247, 1980.
43. MARSH, N. A. and P. J. GAFFNEY. Exercise-induced fibrinolysis-fact or fiction? Thromb. Haemost. 48:201-203, 1982.
44. MATHIS, P. C, H. WOHL, F. R. WALLACH, and R. L. ENGLER. Lack of release of platelet factor 4 during exercise-induced myocardial ischemia. N. Engl. J. Med. 304:1275-1278, 1981.
45. MEHTA, J. and P. MEHTA. Comparison of platelet function during exercise in normal subjects and coronary artery disease patients: potential role of platelet activation in myocardial ischemia. Am. Heart J. 103:49-53,1982.
46. MEHTA, J., P. MEHTA, and C. HORALEK. The significance of platelet-vessel wall prostaglandin equilibrium during exercise-induced stress. Am. Heart J. 105:895-900,1983.
47. OHRI, V. C, J. C. CHATTERJI, B. K. DAS, M. AKHTAR, S. C. TEWARI, P. BHATTACHARJI, and A. BEHL. Effect of submaximal exercise on haematocrit, platelet count, platelet aggregation and blood fibrinogen levels. J. Sports Med. 23:127-130, 1983.
48. PATRONO, C, G. CIABATTONI, F. PUGLIESE, A. PIERUCCI, I. A. BLAIR, and G. A. FITZGERALD. Estimated rate of thromboxane secretion into the circulation of normal humans. J. Clin. Invest. 77:590-594, 1986.
49. PEATFIELD, R. C, M. J. GAWEL, F. CLIFFORD-ROSE, D. L. GUTHRIE, and T. C. PEARSON. The effects of exercise on platelet numbers and size. Med. Lab. Sci. 42:40-43, 1985.
50. PRENTICE, C. R. M., A. A. HASSANEIN, G. P. MCNICOL, and A. S. DOUGLAS. Studies on blood coagulation, fibrinolysis and platelet function following exercise in normal and splenectomized people. Br. J. Haematol. 23:541-552, 1972.
51. PROWSE, C. V. and J. D. CASH. Physiologic and pharmacologic enhancement of fibrinolysis. Semin. Thromb. Hemost. 10:51-60, 1984.
52. RAURAMAA, R., J. T. SALONEN, K. KUKKONEN-HARJULA, K. SEPPÄNEN, E. SEPPÄLÄ, H. VAPAATALO, and J. HUTTUNEN. Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid: a controlled randomized trial in middle aged men. Br. Med. J. 288:603-606, 1984.
53. RAURAMAA, R., J. T. SALONEN, K. SEPPÄNEN, R. SALONEN, J. M. VENÄLÄINEN, M. IHANAINEN, and V. RISSANEN. Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men. Circulation 74:939-944, 1986.
54. RENNIE, J. A. N., B. BENNETT, and D. OGSTON. Effect of local exercise and vessel occlusion on fibrinolytic activity. J. Clin. Path. 30:350-352, 1977.
55. RIJKEN, D. C, I. JUHAN-VAGUE, and D. COLLEN. Complexes between tissue-type plasminogen activator and proteinase inhibitors in human plasma identified with an immunoradiometric assay. J. Lab. Clin. Med. 101:285-294, 1983.
56. RIZZA, C. R. Effect of exercise on the level of antihaemophilic globulin in human blood. J. Physiol. 156:128-135, 1961.
57. ROSING, D. R., P. BRAKMAN, D. R. REDWOOD, R. E. GOLDSTEIN, G. D. BEISER, T. ASTRUP, and S. E. EPSTEIN. Blood fibrinolytic activity in man. Circ. Res. 27:171-184, 1970.
58. SCHERNTHANER, G., I. MÜHLHAUSER, H. BÖHM, C. SEEBACHER, and H. LAIMER. Exercise induces in vivo platelet activation in patients with coronary artery disease and in healthy individuals. Haemostasis 13:351-357, 1983.
59. SCHMIDT, K. G. and J. W. RASMUSSEN. Are young platelets released in excess from the speen in response to short-term physical exercise? Scand. J. Haematol. 32:207-214, 1984.
60. SIESS, W., R. LORENZ, P. ROTH, and P. C. WEBER. Plasma catecholamines, platelet aggregation and associated thromboxane formation after physical exercise, smoking, or norepinephrine infusion. Circulation 66:44-48, 1982.
61. SMALL, M., A. C. TWEDDEL, A. C. RANKIN, G. D. O. LOWE, C. R. M. PRENTICE, and C. D. FORBES. Blood coagulation and platelet function following maximal exercise: effects of beta-adrenoceptor blockade. Haemostasis 14:262-268,1984.
62. STIBBE, J. Effect of exercise on F VHI-complex: proportional increase of ristocetin cofactor (von Willebrand Factor) and F VIII-AGN, but disproportional increase of F VIII-AHF. Thromb. Res. 10:163-168, 1977.
63. TANIGUCHI, N., H. FURUI, K. YAMAUCHI, and I. SOTOBATA. Effects of treadmill exercise on platelet functions and blood coagulating activities in healthy men. Jpn. Heart J. 25:167-180, 1984.
64. VINCENTE, V., I. ALBERCA, and P. M. MANNUCCI. Reduced effect of exercise and DDAVP on factor VHI-von Willebrand factor and plasminogen activator after sequential application of both stimuli. Thromb. Haemost. 51:129-130, 1984.
65. WARLOW, C. P. and D. OGSTON. Effect of exercise on platelet count, adhesion, and aggregation. Acta Haematol. 52:47-52, 1974.
66. WHEELER, M. E., G. L. DAVIS, W. J. GILLESPIE, and M. M. BERN. Physiological changes in hemostasis associated with acute exercise. J. Appl. Physiol. 60:986-990, 1986.
67. WILLIAMS, R. S., E. E. LOGUE, J. L. LEWIS, T. BARTON, N. W. STEAD, A. G. WALLACE, and S. V. PIZZO. Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults. N. Engl. J. Med. 302:987-991, 1980.
68. WILLIAMS, R. S., S. EDEN, and J. ANDERSEN. Reduced epinephrine-induced platelet aggregation following cardiac rehabilitation. J. Clin. Res. 1:127-134, 1981.
69. YAMAMOTO, J., U. OKAMOTO, S. MORITA, K. KIKUI, and Y. FUJII. Production of the modified form of human plasminogen in the plasma activated by urokinase. Jpn. J. Physiol. 33:469-484, 1983.