Liposomal Sustained-Release Delivery Systems for Intravenous Injection. II. Design of Liposome Carriers and Blood Disposition of Lipophilic Mitomycin C Prodrug-Bearing Liposomes

Chemical and Pharmaceutical Bulletin

Volumn 36, Issue 9, 1988, Pages 3557-3564

  Tokunaga, Yuji ^a   Iwasa, Tomoaki ^a   Fujisaki, Jiro ^a   Sawai, Seiji ^a   Kagayama, Akira ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

blood clearance; controlled dialysis; intravenous injection; lipophilic prodrug; liposome; mitomycin C; narrow size distribution; surface charge; sustained release; vesicle size

Indexed keywords

DRUG CARRIER; LIPOSOME; MITOMYCIN C;

BIOAVAILABILITY; DRUG CLEARANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; RAT; SURFACE CHARGE; SUSTAINED RELEASE PREPARATION;

ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DRUG DESIGN; FEMALE; INJECTIONS, INTRAVENOUS; LIPOSOMES; MALE; MICE; MICE, INBRED ICR; MITOMYCIN; MITOMYCINS; PRODRUGS; RATS; RATS, INBRED STRAINS;

EID: 0023735229     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.36.3557     Document Type: Article

References (19)

1. R. L. Juliano (ed.), “Drug Delivery Systems,” Oxford University Press, New York, 1980
2. R. L. Juliano (ed.), “Drug Delivery Systems,” Oxford University Press, New York, 1980
3. G. Scherphof, J. Damen, and D. Hoekstra, “Liposomes: From Physical Structure to Therapeutic Applications,” ed. by C. G. Knight, Elsevier/North-Holland Biomedical Press, Amsterdam, 1981, pp. 299—321.
4. D. A. Tyrrell, V. J. Richardson, and B. E. Ryman, Biochim. Biophys. Acta, 497, 469 (1977).
5. G. Lopez-Berestein, L. Kasi, M. G. Rosenblum, T. Haynei, M. Jahns, H. Gleen, R. Mehta, G. M. Mayligit, and E. M. Hersh. Cancer Res., 44, 375 (1984).
6. I. J. Fidler, S. Sone, W. E. Fogler, and Z. L. Barnes, Cancer Res., 78, 1680 (1981).
7. Y. Sato, H. Kiwada, and Y. Kato, Chem. Pharm. Bull., 34, 4244 (1986).
8. H. M. Patel, N. S. Tuzel, and B. E. Ryman, Biochim. Biophys. Acta, 761, 142 (1983).
9. J. Senior and G. Gregoriadis, Biochim. Biophys. Acta, 30, 2123 (1982).
10. O. Zumbuehl and H. G. Weder, Biochim. Biophys. Acta, 640, 252 (1981).
11. Y. Tokunaga, T. Iwasa, J. Fujisaki, S. Sawai, and A. Kagayama, Chem. Pharm. Bull., 36, 3060 (1988).
12. J. A. Monti, S. T. Christian, and W. A. Shaw, J. Lipid Res., 19, 222 (1978).
13. D. Papahadjopoulos, G. Poste, B. E. Schaeffer, and W. J. Vail, Biochim. Biophys. Acta, 352, 10 (1974).
14. M. C. Finkelstein and G. Weissman, Biochim. Biophys. Acta, 587, 202 (1979);
15. C. F. Schmidt, Y. Barenholtz, and T. E. Thompson Biochemistry 16, 2649 (1977).
16. H. Sasaki, T. Kakutani, M. Hashida, T. Kimura, and H. Sezaki, Chem. Pharm. Bull., 33, 2968 (1985).
17. F. Olson, C. A. Hunt, F. C. Szoka, W. J. Vail, and D. Papahadjopoulos, Biochim. Biophys. Acta, 557, 9 (1979);
18. M. Hashida, A. Kato, Y. Takakura, and H. Sezaki, Drug Metab. Disp., 12, 492 (1984).
19. B. Barlogie and B. Drewinko, Cancer Res., 40, 1973 (1980);