Variation in Tumor Yield in the Prostate and other Target Organs of the Rat in Response to Varied Dosage and Duration of Administration

Cancer Research

Volumn 48, Issue 16, 1988, Pages 4629-4632

  Ito, Nobuyuki ^a   Shirai, Tomoyuki ^a   Tagawa, Yoshiaki ^a   Nakamura, Atsushi ^a   Fukushima, Shoji ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2',3 DIMETHYL 4 BIPHENYLAMINE; ETHINYLESTRADIOL;

ANIMAL EXPERIMENT; AUTOPSY; CARCINOGENESIS; DIET; HISTOLOGY; INTESTINE CANCER; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROSTATE CANCER; SUBCUTANEOUS DRUG ADMINISTRATION;

AMINOBIPHENYL COMPOUNDS; ANIMAL; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; PROSTATIC NEOPLASMS; RATS; RATS, INBRED F344; SUPPORT, NON-U.S. GOV'T; TESTIS; TIME FACTORS;

EID: 0023730851     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

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2. Shirai, T., Sakata, T., Fukushima, S., Ikawa, E., and Ito, N. Rat prostate as one of the target organs for 3,2 '-dimethyl-4-aminobiphenyl-induced carcinogenesis: effects of dietary ethinyl estradiol and methyltestosterone. Gann, 76:803-808, 1985.
3. Shirai, T., Fukushima, S., Ikawa, E., Tagawa, Y., and Ito, N. Induction of prostate carcinoma in situ at high incidence in F344 rats by a combination of 3,2’-dimethyl-4-aminobiphenyl and ethinyl estradiol. Cancer Res., 46: 6423-6426,1986.
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5. Shirai, T., Ikawa, E., Tagawa, Y., and Ito, N. Lesions of the prostate glands and seminal vesicles induced by N-methylnitrosourea in F344 rats pretreated with ethinyl estradiol. Cancer Lett., 35:7-15, 1987.
6. Pour, P. M. Prostatic cancer induced in MRC rats by N-nitrosobis(2-oxopropyl)amine and N-nitrosobis(2-hydroxypropyl)amine. Carcinogenesis (Lond.), 4:49-55,1983.
7. Pour, P. M., and Stepan, K. Induction of prostatic carcinomas and lower urinary tract neoplasms by combined treatment of intact and castrated rats with testosterone propionate and N-nitrosobis(2-oxypropyl)amine. Cancer Res., 47:5699-5706,1987.
8. Waalkes, M. P., Rehm, S., and Perantoni, A. Cadmium-induced prostatic tumors in rats: correlation with prostatic metallothionein deficiency. Proc. Am. Assoc. Cancer Res., 28:25,1987.
9. Pollard, M., Snyder, D. L., and Luckert, P. H. Dihydrotestosterone does not induce prostate adenocarcinoma in L-W rats. Prostate, 10:325-331,1987.