A clinical trial of nonoxynol-9 for preventing gonococcal and chlamydial infections

Journal of Infectious Diseases

Volumn 158, Issue 3, 1988, Pages 518-523

  Louv, William C ^a   Austin, Harland ^a   James Alexander, W ^a   Stagno, Sergio ^a   Cheeks, Jane ^a  

^a Jefferson County Department of Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONOXINOL 9;

ADULT; BIRTH CONTROL; CHLAMYDIA TRACHOMATIS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; NEISSERIA GONORRHOEAE; NONHUMAN; ORAL CONTRACEPTION; PRIORITY JOURNAL; TOPICAL DRUG ADMINISTRATION;

ADULT; CHLAMYDIA INFECTIONS; CLINICAL TRIALS; DOUBLE-BLIND METHOD; FEMALE; GONORRHEA; HUMAN; NONOXYNOL; POLYETHYLENE GLYCOLS; RANDOM ALLOCATION; SPERMATOCIDAL AGENTS; SUPPORT, U.S. GOV'T, P.H.S.; VAGINAL CREAMS, FOAMS AND JELLIES;

EID: 0023726243     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/158.3.518     Document Type: Article

References (16)

1. Bolch OH Jr, Warren JC. In vitro effects of Emko oh Neis-serra gonorrhoeae and Trichomonas vaginalis. Am J Obstet Gynecol 1973;115:1145-8
2. Cowan ME, Cree GE. A note in the susceptibility of N. gonor rhoeae to contraceptive agent nonyl-P. British Journal of Venereal Disease 1973;49:65-6
3. Singh B, Cutler JC, Utidjian HMD. Studies on the development of a vaginal preparation providing both prophylaxis against venereal disease and other genital infections and contraception. II. Effect in vitro of vaginal contraceptive and non-contraceptive preparations on Treponema pallidum and Neisseria gonorrhoeae. British Journal of Venereal Disease 1972;48:57-64
4. Kelly JP, Reynolds RB, Stagno S, Louv WC, Alexander WJ. In vitro activity of the spermicide nonoxynol-9 against Chlamydia trachomatis. Antimicrob Agents Chemother 1985;27:760-2
5. Benes S, McCormack WM. Inhibition of growth of Chlamydia trachomatis by nonoxynol-9 in vitro. Antimicrob Agents Chemother 1985;27:724-6
6. Rendon AL, Covarrubias J, McCarney KE, Marion-Landais G, Luna del Villar J. A controlled, comparative study of phenylmercuric acetate, nonoxynol-9 and placebo vaginal suppositories as prophylactic agents against gonorrhea. Current Therapeutic Research 1980;27:780-3
7. Cutler JC, Balwant S, Carpenter U. Vaginal contraceptives as prophylaxis against gonorrhea and other sexually transmissible diseases. Advances in Planned Parenthood 1977; 12:45-56
8. Jick H, Hannon MT, Stergachis A, Heidrich F, Peiera DR, Rothman KJ. Vaginal spermicides and gonorrhea. JAMA 1982;248:1619-21
9. Austin H, Louv WC, Alexander WJ. A case-control study of spermicides and gonorrhea. JAMA 1984;251:2822-4
10. Rosenberg MJ, Rojanapithayakorn W, Feldblum PJ, Higgins JE. Effect of the contraceptive sponge on chlamydial infection, gonorrhea, and candidiasis. A comparative clinical trial. JAMA 1987;257:2308-12
11. Cates W Jr, Weisner PJ, Curran JW. Sex and spermicides: Preventing unintended pregnancy and infection. JAMA 1982;248:1636-7
12. Cox DR. Regression models and life tables. Journal of the Royal Statistical Society Series B 1972;34:187-202
13. Prentice RL, Williams BJ, Peterson AV. On the regression analysis of multivariate failure time data. Biometrika 1981;68:373-9
14. Rothman KJ. Modern Epidemiology. Boston: Little Brown, 1986
15. Kappus EW, Quinn TC. The spermicide nonoxynol-9 does not inhibit Chlamydia trachomatis in vitro. Sex Transm Dis 1986;3:134-7
16. Ihm MR, Stamm WE, Handsfield HH, Stephens R, Kuo C-C, Holmes KK, Ditzenberger K, Krieger M, Nowinski RC. Culture-independent diagnosis of Chlamydia trachomatis using monoclonal antibodies. New Engl J Med 1984; 310:1146-50