Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes

Journal of Cancer Research and Clinical Oncology

Volumn 114, Issue 4, 1988, Pages 347-358

  Jennerwein, Margaretha ^a   Wappes, Beate ^a   Gust, Ronald ^a   Schönenberge, Helmut ^a   Engel, Jürgen ^b   Seeber, Siegfried ^c   Osieka, Reinhardt ^d  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b EVONIK INDUSTRIES AG   (Germany)

^c KLINIKUM LEVERKUSEN   (Germany)

^d UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Antitumor effect; Dichloro (1,2 diphenylethylenediamine)platinum(II) complexes; Ring substituents

Indexed keywords

PLATINUM DICHLORO 1,2 DIPHENYLETHYLENEDIAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA, EHRLICH TUMOR; CELL LINE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMAN; LEUKEMIA P388; ORGANOPLATINUM COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0023724642     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/BF02128177     Document Type: Article

References (18)

1. Lymphocytic leukemia P 388 of the DBA/2 mouse
2. Pseudo-halogens VII Scope and mechanism of addition of N,N-dichloro-urethane to monoolefinic compounds
3. Pseudo-halogens. VIII. New synthesis of aziridines and oxazolidones
4. Protocols for screening chemical agents and natural products against animal tumors and other biological systems
5. Enantiomeric cisplatin analogues; an investigation on their activity towards tumors in mice
6. Mutagenicity of substituted (o-phenylenediamine)platinum dichloride in the Ames test. A quantitative structure-activity analysis
7. Ultraviolet difference spectral study of the interaction of DNA with platinum complexes
8. Interaction of DNA with antitumor active platinum complexes. Platinum complex involving meso diamine ligand gave two Pt-d(GpG)adducts
9. Ring substituted [1,2-bis(4-hydroxy phenyl)ethylenediamine] dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma
10. Synthesis of platinum(II) complexes of 4-substituted o-phenylendiamine derivatives and determination of their antitumor activity
11. Effects of estrone, estradiol and estriol on hormone responsive human breast cancer in long-term tissue culture
12. Platinum(II) and palladium(II) complexes with amino acid derivatives. Synthesis, interpretation of IR and1H-NMR spectra and conformational implications
13. Preparation of antitumor platinum(II) complexes of 1,2-diphenylethylenediamine isomers and their interaction with DNA and its purine moieties
14. Konfigurative Zuordnung diastereomerer N,N′-Dialkyl- α,α′-diphenyläthylen-diamine durch Kernresonanzspektroskopie
15. In vivo resistance towards anthracyclines, etoposide and cisdiammineplatinum(II)
16. Die Diaza-Cope-Umlagerung
17. The tumor inhibiting effect of isomeric dichloro(diphenylethylenediamine)platinum(II)-complexes
18. Dichloro 1,2-bis(4-hydroxyphenyl)ethylenediamine platinum(II) complexes: an approach to develop compounds with a specific effect on the hormone-dependent mammary carcinoma