Cytotoxicity and Antitumor Activities of Fungal Bis (naphtho-γ-pyrone) Derivatives

Journal of Pharmacobio-Dynamics

Volumn 11, Issue 9, 1988, Pages 630-635

  Tashiro, Tazuko ^b   Tsuruo, Takashi ^b   Natori, Shinsaku ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^b The Japan Foundation   (Japan)

Author keywords

antitumor effect; cephalochromin; chaetochromin; KB cell; mycotoxin; naphtho pyrone; ustilaginoidin

Indexed keywords

4H NAPHTHO[2,3 B]PYRAN 4 ONE DERIVATIVE; AURASPERONE; AUROFUSARIN; CEPHALOCHROMIN; CHAETOCHROMIN; FLAVASPERONE; HEMINIGERONE; ISONIGERONE; NIGERONE; NORRUBROFUSARIN; UNCLASSIFIED DRUG; USTILAGINOIDIN;

ANTINEOPLASTIC ACTIVITY; CELL CULTURE; CELL STRAIN KB; CYTOTOXICITY; FUNGUS; GROWTH INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ACREMONIUM; ANIMAL; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CEPHALOSPORINS; CHAETOMIUM; CHEMISTRY; CLAVICEPS; DNA; HUMAN; MICE; NAPHTHALENES; PROTEINS; PYRANS; PYRONES; RNA; TUMOR CELLS, CULTURED;

EID: 0023723836     PISSN: 0386846X     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb1978.11.630     Document Type: Article

References (17)

1. S. Sekita, K. Yoshihira and S. Natori: Chaetochromin, a bis (naphthodihydropyran-4-one) mycotoxin from Chaetomium thielavioideum, Chem. Pharm. Bull., 28, 2428-2435 (1980).
2. S. Sekita, K. Yoshihira, S. Natori, S. Udagawa, T. Muroi, Y. Sugiyama, H. Kurata and M. Umeda: Mycotoxin production by Chaetomium spp. and related fungi, Can. J. Microbiol., 27, 766-772 (1981).
3. K. Koyama, S. Natori and Y. Iitaka: Absolute configurations of chaetochromin A and related bis(naphtho-y-pyrone) mold metabolites, Chem. Pharm. Bull., 35, 4049-4055 (1987).
4. K. Koyama and S. Natori: Chaetochromins B, C and D, bis(naphtho--y-pyrone) derivatives from Chaetomium gracile, Chem. Pharm. Bull., 35, 578-584 (1987).
5. K. Koyama and S. Natori: Further characterization of seven bis(naphtho--y-pyrone) congeners of ustilaginoidins, coloring matters of Claviceps virens (Ustilaginoiclea virens), Chem. Pharm. Bull, 36, 146-152 (1988).
6. S. Shibata, E. Morishita and Y. Arima: Metabolic products of fungi. XXV. Synthesis of rubrofusarin and its derivatives, Chem. Pharm. Bull., 15, 1757 - 1764 (1967).
7. S. Shibata, E. Morishita, T. Takeda and K. Sakata: The structure of aurofusarin, Tetrahedron Let., 1966, 4855-4860.
8. C. P. Gorst-Allman, P. S. Steyn and C. J. Rabie: Structural elucidation of the nigerones, four new naphthopyrones from cultures of Aspergillus niger, J. Chem. Soc., Perkin Trans. 1, 1980,2474-2479.
9. H. Tanaka, P. -L. Wang, O. Yamada and T. Tamura: Yellow pigments of Aspergillus niger and A. awamori. I. Isolation of aurasperone A and related pigments, Agric. Biol. Chem., 30, 107-113 (1966).
10. S. Natori: Structuers of some fungal benzochromones and benzochromanones, “Natural Products Chemistry,” Vol. 3, ed. by K. Nakanishi, T. Goto, S. Ito, S. Natori and S. Nozoe, Kodansha-University Science Books, Tokyo, Mill Valley, California, 1983, pp. 490-492;
11. W. B. Turner: “Fungal Metabolites,” Academic Press, London, 1971, pp. 147-149;
12. W. B. Turner and D. C. Aldridge: “Fungal Metabolites, II,” Academic Press, London, 1983, pp. 124-131;
13. S. T. Saengchantara and T. W. Wallace: Chromanols, chromanones, and chromones, Natural Product Reports, 1986, 467-475.
14. Some toxicological work on chaetochromin A (K. Ohtsubo, Proc. Japan Assoc. Mycotoxicol., No. 12, 28 (1980);
15. Y. Ito and K. Ohtsubo, Bull. Environ. Contam. Toxicol., 39, 299 (1987);
16. T. Tsuchi-Ya, S. Sekita, K. Koyama, S. Natori and A. Takahashi, Cong. Anom., 27, 245 (1987)
17. S. Ghosal, K. Biswas and D. K. Chakrabarti, J. Agric. Food Chem., 27, 1347 (1979)