The α2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP)

European Journal of Pharmacology

Volumn 151, Issue 3, 1988, Pages 365-371

  Bianchi, Giancarlo ^a   Caccia, Silvio ^a   Della Vedova, Franco ^a   Garattini, Silvio ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Buspirone; Clonidine; Gepirone; Ipsapirone; PmP (1 (2 pyrimidinyl) piperazine); 2 Adrenoceptors

Indexed keywords

1 (2 PYRIMIDINYL)PIPERAZINE; ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; GEPIRONE; IPSAPIRONE;

ANIMAL EXPERIMENT; DRUG BLOOD LEVEL; DRUG METABOLISM; GASTROINTESTINAL TRANSIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADRENERGIC ALPHA-ANTAGONISTS; ANIMAL; ANTI-ANXIETY AGENTS; BUSPIRONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONIDINE; DRUG INTERACTIONS; GASTROINTESTINAL TRANSIT; INJECTIONS, INTRAVENOUS; MALE; PYRIMIDINES; RATS; SUPPORT, NON-U.S. GOV'T;

EID: 0023715880     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(88)90532-8     Document Type: Article

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