The Effect of Diltiazem on Mortality and Reinfarction after Myocardial Infarction

New England Journal of Medicine

Volumn 319, Issue 7, 1988, Pages 385-392

  Abrams, Jonathan ^a   Bigger, J Thomas ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DILTIAZEM;

CLINICAL TRIAL; CONTROLLED STUDY; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

AGED; CLINICAL TRIALS; DILTIAZEM; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMAN; MALE; MIDDLE AGE; MYOCARDIAL INFARCTION; PULMONARY EDEMA; RECURRENCE; STROKE VOLUME; SUPPORT, NON-U.S. GOV'T;

EID: 0023713599     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198808183190701     Document Type: Article

References (39)

1. Yusuf S, Peto R, Lewis J, Collins R, Sleight P. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985; 27: 335–71.
2. Antman E, Muller J, Goldberg S, et al. Nifedipine therapy for coronary-artery spasm: experience in 127 patients. N Engl J Med 1980: 302:1269–73.
3. Subramanian VB. Bowles M, Lahiri A. Davies AB. Raftery EB. Long-term antianginal action of verapamil assessed with quantitated serial treadmill stress testing. Am J Cardiol 1982; 48: 529–35.
4. Hossack KF, Pool PE, Steel P, et al. Efficacy of diltiazem in angina on effort: a multicenter trial. Am J Cardiol 1982; 49: 567–72.
5. Strauss WE, McIntyre KM, Parisi AF, Shapiro W. Safety and efficacy of diltiazem hydrochloride for the treatment of stable angina pectoris: report of a cooperative clinical trial. Am J Cardiol 1982; 49: 560–6.
6. Pepine CJ, Feldman RL, Hill JA, et al. Clinical outcome after treatment of rest angina with calcium blockers: comparative experience during the initial year of therapy with diltiazem, nifedipine, and verapamil. Am Heart J 1983; 106: 1341–7.
7. Boden WE, Bough EW, Reichman MJ, et al. Beneficial effects of high-dose diltiazem in patients with persistent effort angina on β-blockers and nitrates: a randomized, double-blind, placebo-controlled cross-over study. Circulation 1985; 71: 1197–205.
8. McCall D, Walsh RA, Frohlich ED, O'Rourke RA. Calcium entry blocking drugs: mechanisms of action, experimental studies and clinical uses. Curr Probl Cardiol 1985; 10(8):1–80.
9. Kostuk WJ, Pflugfelder P. Comparative effects of calcium entry–blocking drugs, β-blocking drugs, and their combination in patients with chronic stable angina. Circulation 1987; 75: Suppl V: V-114–V-121.
10. Vanhoutte PM. Differential effects of calcium entry blockers on vascular smooth muscle. In: Weiss GB, ed. New perspectives on calcium antagonists. Bethesda, Md.: American Physiological Society, 1981:109–21.
11. McCall D. Excitation–contraction coupling in cardiac and vascular smooth muscle: modification by calcium-entry blockade. Circulation 1987; 75: Suppl V: V-3–V-14.
12. Miller LS, Barrett JN, Cameron JS, Bassett AL. Differential effects of calcium antagonists on viability of adult rat ventricular myocytes. J Mol Cell Cardiol 1985; 17: 1129–37.
13. Sanguinetti MC, Kass RS. Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists. Circ Res 1984; 55: 336–48.
14. Takahara K, Kuroiwa A, Matsushima T, Nakashima Y, Takasugi M. Effects of nifedipine on platelet function. Am Heart J 1985; 109: 4–8.
15. Johnson GJ, Leis LA, Francis GS. Disparate effects of calcium-channel blockers, nifedipine and verapamil, on α2:-adrenergic receptors and THROMBOXANE A2-induced aggregation of human platelets. Circulation 1986; 73: 847–54.
16. The Danish Study Group on Verapamil in Myocardial Infarction. Verapamil in acute myocardial infarction. Eur Heart J 1984; 5: 516–28.
17. Sirnes PA, Overskeid K. Pedersen TR, et al. Evolution of infarct size during the early use of nifedipine in patients with acute myocardial infarction: the Norwegian Nifedipine Multicenter Trial. Circulation 1984; 70: 638–44.
18. Muller JE, Morrison J, Stone PH, et al. Nifedipine therapy for patients with threatened and acute myocardial infarction: a randomized, double-blind, placebo-controlled comparison. Circulation 1984; 69: 740–7.
19. Wilcox RG, Hampton JR, Banks DC, et al. Trial of early nifedipine treatment in patients with suspected myocardial infarction (the TRENT study). Br Heart J 1986; 55: 506. abstract.
20. Lubsen J, Tijssen JGP, Kerkkamp HJJ. Early treatment of unstable angina in the coronary care unit: randomised, double-blind, placebo controlled comparison of recurrent ischaemia in patients treated with nifedipine or metoprolol or both: report of the Holland InterUniversity Nifedipine/Metoproloi Trial (HINT) Research Group. Br Heart J 1986; 56: 400–13.
21. Snyder SH, Reynolds IJ. Calcium-antagonist drugs: receptor interactions that clarify therapeutic effects. N Engl J Med 1985; 313: 995–1002.
22. Gibson RS, Boden WE, Theroux P, et al. Diltiazem and reinfarction in patients with non-Q-wave myocardial infarction: results of double-blind, randomized, multicenter trial. N Engl J Med 1986; 315: 423–9.
23. Davis HT, Cox C. The M-coin design: a method for sequentially allocating subjects in controlled clinical trials. Univ Rochester Tech Rep 1987; 87–04:1–29.
24. The Criteria Committee of the New York Heart Association. Nomenclature and criteria for diagnosis of diseases of the heart and great vessels. 7th ed. Boston: Little, Brown, 1973.
25. Birman KP, Rolnitzky LM, Bigger JT Jr. A shape-oriented system for automated Hoher ECG analysis. In: Computers in cardiology: September 12–14, 1978, Stanford University, Palo Alto, Calif. Long Beach, Calif.: IEEE Computer Society, 1978: 217–20.
26. Bigger JT Jr, Fleiss JL, Kleiger R, Miller JP, Rolnitzky LM, Multicenter Post-Infarction Research Group. The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction. Circulation 1984; 69: 250–8.
27. Greenberg H, Gillespie J, Dwyer EM Jr. Multicenter Post-Infarction Research Group. A new electrocardiographic classification for post-myocardial infarction clinical trials. Am J Cardiol 1987; 59: 1057–63.
28. Hinkle LE Jr, Thaler HT. Clinical classification of cardiac deaths. Circulation 1982; 65: 457–64.
29. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457–81.
30. Cox DR. Regression models and life-tables. J R Stat Soc [B] 1972; 34: 187–220.
31. Dixon WJ, Brown MB, Engelman L, et al. BMDP statistical software. Los Angeles: University of California Press, 1983:576–94.
32. Armitage P, Parmar M. Some approaches to the problem of multiplicity in clinical trials. In: Proceedings of the 13th International Biometrie Conference. Seattle: Biometric Society, 1986.
33. Pocock SJ, Hughes MD, Lee RJ. Statistical problems in the reporting of clinical trials: a survey of three medical journals. N Engl J Med 1987; 317: 426–32.
34. Porter CB, Walsh RA, Badke FR, O'Rourke RA. Differential effects of diltiazem and nitroprusside on left ventricular function in experimental chronic volume overload. Circulation 1983; 68: 685–92.
35. Murakami T, Hess OM, Krayenbuehl HP. Left ventricular function before and after diltiazem in patients with coronary artery disease. J Am Coll Cardiol 1985; 5: 723–30.
36. Walsh RA. The effects of calcium-entry blockade on left ventricular systolic and diastolic function. Circulation 1987; 75: Suppl V: V-43–V-55.
37. Packer M, Lee WH, Medina N, Yushak M. Comparative negative inotropic effects of nifedipine and diltiazem in patients with severe left ventricular dysfunction. Circulation 1985; 72: Suppl III: III-275. abstract.
38. Packer M, Kessler PD, Lee WH. Calcium-channel blockade in the management of severe chronic congestive heart failure: a bridge too far. Circulation 1987; 75: Suppl V: V-56–V-64.
39. Yasue H, Omote S, Takizawa A, Nagao M, Miwa K, Tanaka S. Exertional angina pectoris caused by coronary arterial spasm: effects of various drugs. Am J Cardiol 1979; 43: 647–52.