Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

Cell

Volumn 54, Issue 1, 1988, Pages 105-115

  Muller, William J ^a   Sinn, Eric ^a   Pattengale, Paul K ^b   Wallace, Racheal ^c   Leder, Philip ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; BREAST ADENOCARCINOMA; CARCINOGENESIS; CONTROLLED STUDY; CYTOLOGY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; TRANSGENIC ANIMAL; ULTRASTRUCTURE;

ADENOCARCINOMA; ANIMAL; CELL TRANSFORMATION, NEOPLASTIC; EPIDIDYMIS; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION; HYPERPLASIA; HYPERTROPHY; MALE; MAMMAE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; ONCOGENES; ORGAN SPECIFICITY; PAROTID GLAND; PHENOTYPE; PROTO-ONCOGENE PROTEINS; RECEPTOR, ERBB-2; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023713558     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(88)90184-5     Document Type: Article

References (48)

1. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
2. The neu oncogene encodes an epidermal growth factor receptor-related protein
3. Multiple independent activations of the c-neu oncogene by a point mutation altering the trans-membrane domain of p185
4. Endothelial cell tumors develop in transgenic mice carrying polyoma virus middle T oncogene
5. Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation
6. Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors
7. The hormone response element of the mouse mammary tumor virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal region
8. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
9. Polyoma virus transforming protein associates with the product of the c-src cellular gene
10. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
11. Rapid DNA isolations for enzymatic and hybridization analysis
12. erbB-2 is a potent oncogene when overexpressed in NIH3T3 cells
13. Genetic alteration of the c-myc proto-oncogene (MYC) in human primary breast carcinomas
14. An improved in situ hybridization method for detection of cellular RNA in Drosophila tissue sections and its application for localizing transcripts of homeotic antennapedia gene complex
15. Heritable-formation of pancreatic beta cell tumors in transgenic mice expressing recombinant insulin/SV40 oncogenes
16. Glucocorticoid regulation of the Ha-MuSV p21 gene conferred by sequences from mouse mammary tumor virus
17. HER2 causes transformation and tumorigenesis of NIH3T3 cells
18. Amplification of a novel v-erbB-related gene in human mammary carcinoma
19. Prolactin and breast cancer
20. Stage- and tissue-specific expression of the c-neu oncogene in rat development
21. Over-expression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms
22. Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development
23. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriphage SP6 promoter
24. Selection for animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyl transferase
25. Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastoma
26. Germline transformation of mice
27. Experimental models of lymphoproliferative disease: the mouse as a model for human non-Hodgkins lymphomas related leukemias
28. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice
29. Preservation of hamster oocytes to assay the fertilizing capacity of human spermatozoa
30. Labeling deoxyribonucleic acid to high, specific activity in vitro by nick-translation with DNA polymerase 1
31. Deregulated c-fos expression interferes with normal bone development in transgenic mice
32. The c-neu oncogene: an erbB-related gene encoding a 185,0000-Mw tumour antigen
33. The c-neu gene: an erbB-homologous gene distinct from and unlinked to genes encoding the EGF receptor
34. Targeted c-myc expression in mammary glands of transgenic mice induces constitutive milk protein gene transcription
35. A v-erbB related proto-oncogene, c-erbB-2 is distinct from c-erbB-1/epidermal growth factor receptor gene and is amplified in a human salivary gland adenocarcinoma
36. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts
37. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice synergistic actions of oncogenes in vivo
38. Human breast cancer: correlation of relapse and survival with amplification of HER-2/neu oncogene
39. Detection of specific sequences among DNA fragments separated by gel electrophoresis
40. p185, product of the c-neu proto-oncogene is a receptor-like protein associated with tyrosine kinase activity
41. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/mvc fusion genes
42. Multiple regulatory domains in the mouse mammary tumor virus long terminal repeat revealed by analysis of fusion genes in transgenic mice
43. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose
44. Amplification of the c-neu (c-erbB-2) oncogene in human mammary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene
45. Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene
46. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methyl urea during initiation of mammary carcinogenesis in rats
47. Localized expression of teh atrial natriuretic factor gene during cardiac embryogenesis
48. Nucleocytoplasmic distribution of snRNPs and stockpiled snRNA-binding proteins during oogenesis and early development in Xenopus leavis