Safety and efficacy of chymopapain (Disease) in the treatment of sciatica due to a herniated nucleus puiposus: Results of a randomized, double-blind study

Spine

Volumn 13, Issue 5, 1988, Pages 561-565

  Dabezies, E J ^a   Langford, K ^a   Morris, J ^a   Shields, C B ^a   Wilkinson, H A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Chymopapain; Clinical experience; Double blind study; Herniated nucleus puiposus

Indexed keywords

CHYMOPAPAIN;

ANAPHYLAXIS; BRADYCARDIA; CHEMONUCLEOLYSIS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN EXPERIMENT; INTERVERTEBRAL DISK HERNIA; ISCHIALGIA; MAJOR CLINICAL STUDY; MALE; MUSCLE SPASM; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANAPHYLAXIS; CHYMOPAPAIN; DOUBLE-BLIND METHOD; DRUG HYPERSENSITIVITY; HUMAN; INTERVERTEBRAL DISK CHEMOLYSIS; INTERVERTEBRAL DISK DISPLACEMENT; MIDDLE AGE; MUSCULAR DISEASES; RANDOM ALLOCATION; SCIATICA; SPASM; SPINE;

EID: 0023706866     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/00007632-198805000-00022     Document Type: Article

References (20)

1. Agre K: Serious neurological adverse events associated with administration of Chymodiactin. Chemonucleolysis. Edited by JE Brown, Nordby, and L Smith. Thorofare, New Jersey, Slack Inc, 1985, pp 203-315
2. Boots Pharmaceuticals, 1987, (personal communication).
3. Brown MD, Daroff RB: The double-blind study comparing Disease to placebo: An editorial comment. Spine 2:233-236, 1977
4. Chymopapain: A case study in federal drug regulation. JAMA 240:195-219, 1978
5. Chymopapain administration procedures modified. FDA Drug Bulletin, 14:14-15, 1984
6. Davis RJ, North RB, Campbell JA, et al: Multiple cerebral hemorrhages following chymopapain chemonucleolysis: Case report. J Neurosurg 61:169-171, 1984
7. Dyck P: Paraplegia following chemonucleolysis: A case report and discussion of neurotoxicity. Spine 10:359-362,1985
8. Fraser RD: Chymopapain for the treatment of intervertebral disc hemation: A preliminary report of a double-blind study. Spine 7:608-612, 1982
9. Haines SJ: The chymopapain clinical trials. Neurosurgery 17:107-110, 1985
10. Javid MJ: Treatment of herniated lumbar disc syndrome with chymopa¬pain. JAMA 243:2043-2048, 1980
11. Javid MJ, Nordby EJ, Ford LT, et al: Safety and efficacy of chymopapain (Chymodiactin) in herniated nucleus pulposis with sciatica: Results of a randomized, double-blind study. JAMA 249:2489-2494, 1983
12. Martins AN, Ramirez A, Johnston J, Schwetschenau PR: Double-blind evaluation of chemonucleolysis for herniated lumbar discs: Late results. J Neurosurg 49:816-827, 1978
13. McCulloch JA: Chemonucleolysis: Experience with 2000 cases. Clin Orthop 146:128-135, 1980
14. Norton WL: Chemonucleolysis versus surgical discectomy: Comparison of costs and results in workman’s compensation claimants. Spine 11:440-443, 1986
15. Ramirez LF, Javid MJ: Cost effectiveness of chemonucleolysis versus laminectomy in the treatment of herniated nucleus puiposus. Spine 10:363-367, 1985
16. Schwetschenau PR, Ramirez A, Johnston J, et al: Double-blind evaluation of intradiscal chymopapain for herniated lumbar discs: Early results. J Neurosurg 45:622-627, 1976
17. Shields CB, Reiss S, Garretson HD: Chemonucleolysis with chymopapain. Results of 150 patients. Presented at the AANS Meeting, Denver, 1986
18. Smith L: Enzymatic dissolution of the neucleus puiposus in humans. JAMA 187:137-140, 1964
19. Smith L: Failure of chemonucleolysis. Orthop Clin North Am 6:255-258, 1975
20. Watts C: Complications of chemonucleolysis for lumbar disc disease. Neurosurgery 1:2-5, 1977