Topsentin, Bromotopsentin, and Dihydrodeoxybromotopsentin: Antiviral and Antitumor Bis(Indolyl)imidazoles from Caribbean Deep-Sea Sponges of the Family Halichondriidae. Structural and Synthetic Studies

Journal of Organic Chemistry

Volumn 53, Issue 23, 1988, Pages 5446-5453

  Tsujii, Shinji ^a   Rinehart, Kenneth L ^a   Gunasekera, Sarath P ^b   Cross, Susan S ^b   Lui, May S ^b   Pomponi, Shirley A ^b   Cristina Diaz, M ^b   Kashman, Yoel ^c  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b FLORIDA ATLANTIC UNIVERSITY   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOTOPSENTIN; TOPSENTIN; TOPSENTIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL CULTURE; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INVERTEBRATE; LEUKEMIA P 388; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; TUMOR CELL; VIRUS;

EID: 0023701215     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo00258a009     Document Type: Article

References (14)

1. Norton, R. S.; Wells, R. J. J. Am. Chem. Soc. 1982,104, 3628-3635.
2. Moquin, C.; Guyot, M. Tetrahedron Lett. 1984, 25, 5047-5048.
3. Kohmoto, S.; Kashman, Y.; McConnell, O. J.; Rinehart, K. L.; Wright, A.; Koehn, F. E. J. Org. Chem., in press.
4. Bartik, K.; Braekman, J.-C.; Daloze, D.; Stoller, C.; Huysecom, J.; Vandevyver, G.; Ottinger, R. Can. J. Chem. 1987, 65, 2118-2121.
5. Braekman, J. C.; Daloze, D.; Stoller, C. Bull. Soc. Chim. Belg. 1987, 96, 809-812.
6. Tymiak, A. A.; Rinehart, K. L., Jr.; Bakus, G. J. Tetrahedron 1985, 41, 1039-1047.
7. Kobayashi, J.; Harbour, G. C.; Gilmore, J.; Rinehart, K. L., Jr. J. Am. Chem. Soc. 1984, 106, 1526-1528.
8. Pretach, E.; Seibl, J.; Simon, W.; Clero, T. Tables of Spectral Data for Structure Determination of Organic Compounds; Springer-Verlag: Berlin, 1983; p C220.
9. Andersen, R. J.; Stonard, R. J. Can. J. Chem. 1979,57, 2325-2328.
10. Bax, A.; Morris, G. A. J. Magn. Reson. 1981, 42, 501-505.
11. Sato, Y.; Geckle, M.; Gould, S. J. Tetrahedron Lett. 1985, 26, 4019-4022.
12. Kessler, H.; Griesinger, C.; Zarbock, J.; Loosli, H. R. J. Magn. Reson. 1984, 57, 331-336.
13. Bergman, J. J. Heterocycl. Chem. 1970, 7, 1071-1076.
14. Schubert, H. J. Prakt. Chem. 1959, 8, 333-338.